Results 121 to 130 of about 1,857,972 (264)

Hedgehog Pathway Inhibitors: Clinical Implications and Resistance in the Treatment of Basal Cell Carcinoma. [PDF]

Cureus, 2021
Habashy S, Jafri A, Osman HO, Thomas NE, Udekwe S, Heindl SE.   +5 more
europepmc   +1 more source

Methylation of Hedgehog pathway genes.

, 2016
Methylation of Hedgehog pathway genes.
Hakon Hakonarson (102913), Steven F. EauClaire (2580163), Shuang Cui (2428774), Zenobia C. Cofer (2580166), Kathleen M. Loomes (503810), John W. Tobias (261377), Randolph P. Matthews (463285), Cecilia Kim (102878)   +7 more
core   +1 more source

Molecular Basis for Uracil‐DNA‐Glycosylase to Identify DNA Damage in the Nucleosome

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The DNA base‐excision repair (BER) pathway is initiated by a glycosylase, such as uracil‐DNA‐glycosylase (UDG), which identifies and removes a wrong base incorporated in the DNA sequence. The very early steps in the identification of the DNA damage are crucial to the correct initiation of the repair chain, and become even more complex when ...
Safwen Ghediri, Ralf Blossey, Fabrizio Cleri   +2 more
wiley   +1 more source

Multitarget Regulatory Mechanisms and Research Advances of Plant‐Derived Bioactive Ingredients in Hypertension Prevention and Management

Phytotherapy Research, EarlyView.
Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng, Yonglin Zhang, Jing Pan, Jing Luo, Hualin Sun, Chaonian Li, Li Li   +6 more
wiley   +1 more source

Regulating Lipid Metabolism in Cancer: The Therapeutic Potential of Traditional Chinese Medicine

Phytotherapy Research, EarlyView.
By regulating the reprogramming of lipid metabolism in tumor cells, TCM provides a novel strategy for antitumor therapy with reduced toxicity and enhanced efficacy. ABSTRACT Lipid metabolic reprogramming is a key feature of tumor cells to adapt to the microenvironment and plays an important role in tumor growth, invasion, and metastasis.
Yufeng Gao, Huiming Huang, Xuejiao Wei, Xiaoxue Wang, Wanying Xie, Xinyu Qiu, Fei Wang, Zhuguo Wang, Ruoxin Zhang, Yilin Cai, Changhai Qu, Zhongdong Hu   +11 more
wiley   +1 more source

Postauthorization Safety Study (NISSO) Assessing the Long-Term Safety Profile of Sonidegib in Patients With Locally Advanced Basal Cell Carcinoma: Interim Analysis From the Spanish Cohort

Actas Dermo-Sifiliográficas
Background: This study aims to present an interim analysis of safety data from the Spanish cohort of the NISSO post-authorization safety study on the long-term tolerability of sonidegib in patients with locally advanced basal cell carcinoma (laBCC ...
S. Beà Ardébol, G.M. Pérez-Pastor, R. Fernández-de-Misa, R. Botella-Estrada, V. Ruiz-Salas, Á. Flórez, M. Mayor Arenal, M.J. Fuente González, P. Bassas-Freixas, A. Toll, P. Valerón Almazán, R. Arntz, J. Malvehy   +12 more
doaj   +1 more source

Hedgehog inhibitor in scGVHD Supplement

Supplement material for Efficacy of Hedgehog Pathway Inhibitors as Adjuvant in Treating Steroid-Refractory Sclerodermatous Chronic Graft-Versus-Host Disease: Methods and Supplement ...
Weng, Wen-Kai
core   +1 more source

Progress in bone tissue engineering biomaterials: Development, challenges, and prospects

VIEW, EarlyView.
Scheme 1 Application of biomaterials in immunomodulation during bone tissue engineering. Abstract Bone defect repair remains a major clinical challenge in orthopedics. Over 2 million cases caused by trauma, tumors, and other factors occur annually, with large‐scale defects posing a particular bottleneck due to limited self‐healing capacity.
Yuanbin Zhang, Junlei Chai, Quanwei Ding, Luping Liu, Kejie Zhang, Jie Lin, Jianhua Zhang, Youju Huang   +7 more
wiley   +1 more source

Treatment of basal cell carcinoma with Sonidegib and literature review

Pifu-xingbing zhenliaoxue zazhi
Objective To investigate the efficacy and safety of Sonidegib for basal cell carcinoma. Methods Clinical data and skin histology were analyzed in a patient with ulcerated brown plaque on the nasal dorsum.
Ziyue JIA, Zhe ZHUANG, Xinhui LI, Yongfeng CHEN   +3 more
doaj   +1 more source

Responsiveness to Hedgehog Pathway Inhibitors in T-Cell Acute Lymphoblastic Leukemia Cells Is Highly Dependent on 5'AMP-Activated Kinase Inactivation. [PDF]

Int J Mol Sci, 2021
Tosello V, Bongiovanni D, Di Martino L, Franchin C, Zanovello P, Arrigoni G, Piovan E.   +6 more
europepmc   +1 more source