Results 101 to 110 of about 28,708 (231)
Using drug scheduling to manage adverse events associated with hedgehog pathway inhibitors for basal cell carcinoma. [PDF]
Oncotarget, 2021 Lear JT, Dummer R, Guminski A.
europepmc +1 more source
Advances in GPCRs Associated With Wnt Signaling Within the Auditory System
Medicine Bulletin, EarlyView.ABSTRACT G protein‐coupled receptors (GPCRs) that interact with the Wnt signaling pathway are pivotal for auditory system homeostasis, as they orchestrate inner ear development, hair cell (HC) regeneration, and hearing preservation. Frizzled (FZD) receptors, the core Wnt‐related GPCRs, bind Wnt ligands and co‐receptors (e.g., LRP5/6) to activate both ...
Liang Wang +3 more
wiley +1 more source
Hedgehog Pathway Inhibitors: Clinical Implications and Resistance in the Treatment of Basal Cell Carcinoma. [PDF]
Cureus, 2021 Habashy S +5 more
europepmc +1 more source
Traditional Chinese Medicine for lung cancer: Mechanisms, clinical evidence, and future perspectives
Precision Medical Sciences, EarlyView.Graphical abstract represents the risk factors for lung cancer, TCM efficacy and clinical outcomes to future challenges. Abstract Lung cancer remains a leading cause of global cancer mortality. Despite advances in conventional treatments such as surgery, chemotherapy, targeted therapy, and immunotherapy, challenges including drug resistance, toxicity ...
Zhangdeng Chen, Liujun Bao
wiley +1 more source
Integrative Zoology, EarlyView.Multi‐omics analysis reveals that herbivorous adaptation in Lordiphosa flies arises from coordinated interactions across the genome, transcriptome, and gut microbiota: genomic expansions of detoxification (e.g., cytochrome P450s) and carbohydrate metabolism gene families, transcriptomic upregulation of energy pathways like lipid oxidation and ...
Run Guo +4 more
wiley +1 more source
The Role of Hedgehog Signalling Pathway Inhibitors in Squamous Cell Carcinoma of Head and Neck
RGUHS Journal of Medical SciencesSquamous cell carcinoma arising from the head and neck HNSCC is a challenging tumour with high rates of recurrence and limited therapeutic options in advanced stages.
Dr. Manas Bajpai
doaj +1 more source
British Journal of Pharmacology, EarlyView.The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan +3 more
wiley +1 more source
Actas Dermo-SifiliográficasBackground: This study aims to present an interim analysis of safety data from the Spanish cohort of the NISSO post-authorization safety study on the long-term tolerability of sonidegib in patients with locally advanced basal cell carcinoma (laBCC ...
S. Beà Ardébol +12 more
doaj +1 more source
Cancer Science, EarlyView.This study aimed to determine whether personalized selection of effective drugs for SMARCB1/INI1‐deficient tumors is feasible using in vitro drug sensitivity profiling. Drug sensitivity was assessed using a short‐term collagen gel–embedded three‐dimensional drug sensitivity test (3D‐DST) in tumors derived from SMARCB1/INI1‐deficient tumor cell line ...
Hiroaki Goto +12 more
wiley +1 more source
Treatment of basal cell carcinoma with Sonidegib and literature review
Pifu-xingbing zhenliaoxue zazhiObjective To investigate the efficacy and safety of Sonidegib for basal cell carcinoma. Methods Clinical data and skin histology were analyzed in a patient with ulcerated brown plaque on the nasal dorsum.
Ziyue JIA +3 more
doaj +1 more source