Results 81 to 90 of about 28,708 (231)

Activated hedgehog gene pattern correlates with dismal clinical outcome and tumor microenvironment heterogeneity in hepatocellular carcinoma

Heliyon
Background: Activation of the Hedgehog signaling pathway is linked to the initiation and development of human hepatocellular carcinoma (HCC). However, its impact on clinical outcomes and the HCC microenvironment remains unclear.
Limin Zhen, Yi Zhu, Zhen Wu, Jinyao Liao, Liaoyuan Deng, Qianqian Ma, Qili Wu, Gang Ning, Qiuxiong Lin, Liya Zhou, Yanjie Huang, Zewei Zhuo, Ren Chen, Dongnan Yu   +13 more
doaj   +1 more source

Quinolone-1-(2H)-ones as hedgehog signalling pathway inhibitors

Organic & Biomolecular Chemistry, 2016
A series of quinolone-2-(1H)-ones derived from a Ugi-Knoevenagel three- and four-component reaction were prepared exhibiting low micromolar cytotoxicity against a panel of eight human cancer cell lines known to possess the Hedgehog Signalling Pathway (HSP) components, as well as the seminoma TCAM-2 cell line.
Trieu N. Trinh, Eileen A. McLaughlin, Mohammed K. Abdel-Hamid, Christopher P. Gordon, Ilana R. Bernstein, Victoria Pye, Peter Cossar, Jennette A. Sakoff, Adam McCluskey   +8 more
openaire   +4 more sources

The role of Rho GTPases in facial morphogenesis

Developmental Dynamics, EarlyView.
The role of small GTPases, RHOA, RAC1, and CDC42 and pathway mediators is reviewed in the context of embryonic facial development. Lip fusion requires cytoskeletal remodeling during morphogenesis of the facial processes and during lip fusion. Fnm, frontonasal mass; lnp, lateral nasal process; mnp, medial nasal process; mxp, maxillary process; np, nasal
Isra Ibrahim, Joy M. Richman
wiley   +1 more source

Role and inhibition of GLI1 protein in cancer

Lung Cancer: Targets and Therapy, 2018
Eloise Mastrangelo, Mario Milani CNR – Biophysics Institute, c/o Dipartimento di Bioscienze, Università degli Studi di Milano, Milano, Italy Abstract: GLI1 is a transcriptional regulator involved in the development of different types of ...
Mastrangelo E, Milani M
doaj  

Non-Canonical Hedgehog Signaling Is a Positive Regulator of the WNT Pathway and Is Required for the Survival of Colon Cancer Stem Cells

Cell Reports, 2017
Summary: Colon cancer is a heterogeneous tumor driven by a subpopulation of cancer stem cells (CSCs). To study CSCs in colon cancer, we used limiting dilution spheroid and serial xenotransplantation assays to functionally define the frequency of CSCs in ...
Joseph L. Regan, Dirk Schumacher, Stephanie Staudte, Andreas Steffen, Johannes Haybaeck, Ulrich Keilholz, Caroline Schweiger, Nicole Golob-Schwarzl, Dominik Mumberg, David Henderson, Hans Lehrach, Christian R.A. Regenbrecht, Reinhold Schäfer, Martin Lange   +13 more
doaj   +1 more source

Spatiotemporal cellular dynamics of the notochord shape intervertebral disc morphogenesis in the mouse embryo through apoptosis and proliferation

Developmental Dynamics, EarlyView.
Abstract Background The notochord is a midline structure essential for vertebrate embryogenesis, contributing to the development of the nervous system, digestive tract, and vertebral column. In particular, notochord signaling is indispensable for proper patterning and coordinated development of alternating vertebrae and intervertebral discs (IVDs ...
Julie Warin, Estelle Balissat, Pauline Colombier, Lily Paillat, Maeva Dutilleul, Anne Camus   +5 more
wiley   +1 more source

Hedgehog and PI3K/Akt/mTOR Signaling Pathways Involvement in Leukemic Malignancies: Crosstalk and Role in Cell Death

Cells
The Hedgehog (Hh) and PI3K/Akt/mTOR signaling pathways play a pivotal role in driving the initiation and progression of various cancers, including hematologic malignancies such as acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), chronic ...
Mariaconcetta Sicurella, Marica De Chiara, Luca Maria Neri   +2 more
doaj   +1 more source

Targeted Therapies for Pediatric AML: Gaps and Perspective

Frontiers in Pediatrics, 2019
Acute myeloid leukemia (AML) is a hematopoietic disorder characterized by numerous cytogenetic and molecular aberrations that accounts for ~25% of childhood leukemia diagnoses.
Annalisa Lonetti, Andrea Pession, Andrea Pession, Riccardo Masetti   +3 more
doaj   +1 more source

Secretopathies emerge as a new class of neurocristopathies

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient embryonic population of cells that give rise to a wide range of structures, including craniofacial cartilage and bone, peripheral neurons and glia, as well as components of the cardiac outflow tract, among others.
Amanda Teixeira, Cassandra Millet‐Boureima, Joshua A. Moore, Loydie A. Jerome‐Majewska   +3 more
wiley   +1 more source

Basal Cell Carcinoma and Hedgehog Pathway Inhibitors: Focus on Immune Response. [PDF]

Front Med (Lausanne), 2022
Gambini D, Passoni E, Nazzaro G, Beltramini G, Tomasello G, Ghidini M, Kuhn E, Garrone O.   +7 more
europepmc   +1 more source