Results 141 to 150 of about 100,157 (319)
Radial Symmetry on 3D Shells in the Landau-de Gennes Theory [PDF]
arXiv, 2014 We study the stability of the radial-hedgehog solution on a three-dimensional (3D) spherical shell with radial boundary conditions, within the Landau-de Gennes theory for nematic liquid crystals. We show that the radial-hedgehog solution has no zeroes for a sufficiently narrow shell, for all temperatures below the nematic supercooling temperature.
arxiv
Mechanisms of enhancer‐driven oncogene activation
International Journal of Cancer, EarlyView.Abstract An aggressive subtype of acute myeloid leukemia (AML) is caused by enhancer hijacking resulting in MECOM overexpression. Several chromosomal rearrangements can lead to this: the most common (inv(3)/t(3;3)) results in a hijacked GATA2 enhancer, and there are several atypical MECOM rearrangements involving enhancers from other hematopoietic ...
Joyce Vriend +2 more
wiley +1 more source
Molecular subtyping and precision therapy for esophageal cancer
Interdisciplinary Medicine, EarlyView.The molecular typing of esophageal cancer based on genome, transcriptome, proteome, and multi‐omics revealed various molecular features and provided potential targets for the precision therapy. Recent trials have shown that immunotherapy or molecular targeted therapy plus chemoradiotherapy can improve overall survival and progression‐free survival in ...
Guangkun Pei +5 more
wiley +1 more source
Interdisciplinary Medicine, EarlyView.This article evaluates the therapeutic potential of extracellular vesicle‐like particles derived from Chinese herbal medicine (CHM‐EVLP) for a range of diseases. It underscores the significance of traditional Chinese medicine in the development of innovative formulations.
Ying‐qi Cao +6 more
wiley +1 more source
Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus [PDF]
, 1999 Ge Wang, Boyuan Wang, Jin Jiang
openalex +1 more source
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.Different insect species exhibit remarkable diversity in the developmental trajectories from fertilized eggs to hatching larvae. For three myrmicine ant species, we observe a novel combination of a developmental features: small embryonic primordia, a mode of embryogenesis termed short/intermediate germ‐band development, and progressive establishment of
Chi‐Chun Fang +5 more
wiley +1 more source
Cholesterol modification of Hedgehog family proteins [PDF]
, 2002 Juhee Jeong, Andrew P. McMahon
openalex +2 more sources
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Trichosanthes kirilowii is a plant used in traditional Chinese medicine. Its fruits, seeds, and roots can all be used medicinally. The fruit of T. kirilowii has a moistening effect on the lung for arresting cough. However, there is no scientific research to prove that the fruit of T. kirilowii can improve asthma. Herein, we evaluated whether T.
Ting‐Chi Lin +6 more
wiley +1 more source
Hedgehog Acyltransferase Promotes Uptake of Palmitoyl-CoA across the Endoplasmic Reticulum Membrane
Cell Reports, 2019 Summary: Attachment of palmitate to the N terminus of Sonic hedgehog (Shh) is essential for Shh signaling. Shh palmitoylation is catalyzed on the luminal side of the endoplasmic reticulum (ER) by Hedgehog acyltransferase (Hhat), an ER-resident enzyme ...
James J. Asciolla, Marilyn D. Resh
doaj
The middle hedgehog of a planar convex body [PDF]
arXiv, 2016 A convexity point of a convex body is a point with the property that the union of the body and its reflection in the point is convex. It is proved that in the plane a typical convex body (in the sense of Baire category) has infinitely many convexity points.
arxiv