Cholinergic receptor, nicotinic, α3 (CHRNA3); CHRNA5; hedgehog interacting protein (HHIP) [PDF]
, 2009 Sreekumar Pillai
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System level network data and models attack cancer drug resistance
British Journal of Pharmacology, EarlyView.Drug resistance is responsible for >90% of cancer related deaths. Cancer drug resistance is a system level network phenomenon covering the entire cell. Small‐scale interactomes and signalling network models of drug resistance guide directed drug development.
Márk Kerestély +6 more
wiley +1 more source
Synthetic microneurotrophins: Neurotrophin receptors for therapeutics of neurodegenerative diseases
British Journal of Pharmacology, EarlyView.Neurodegenerative disorders are characterised by the chronic progressive degeneration of specific neuronal subtypes, neuroinflammation, myelin damage and synaptic loss. Despite their growing incidence, advancements in effective treatments remain limited, because of lack of knowledge for the aetiology of the diverse pathophysiology to design systematic ...
Ioanna Zota +4 more
wiley +1 more source
Sonic Hedgehog Shedding Results in Functional Activation of the Solubilized Protein [PDF]
, 2011 Stefanie Ohlig +11 more
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Beyond synapses: cytoplasmic connections in brain function and evolution
Biological Reviews, EarlyView.ABSTRACT Following Ramón y Cajal's groundbreaking contributions to the identification of synapses, research in neuroscience predominantly focused on their pivotal role in neural communication (the neuron doctrine), overlooking an intriguing possibility suggested by Golgi of non‐synaptic interactions among neural cells.
Malalaniaina Rakotobe, Chiara Zurzolo
wiley +1 more source
Importance of hedgehog interacting protein and other lung function genes in asthma [PDF]
, 2011 Xingnan Li +19 more
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Cancer Science, EarlyView.Cancer‐associated fibroblasts (CAFs) are the major component of the tumor stroma. This review will highlight the CAF subtypes within the tumor microenvironment and their role in tumor progression. CAF subtype induction by extracellular vesicles (EVs) and their significance, which we reported previously, are also discussed.
Yutaka Naito
wiley +1 more source
Sonic Hedgehog-induced Proliferation Requires Specific Gα Inhibitory Proteins [PDF]
, 2011 Mercedes Barzi +3 more
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Cancer Science, EarlyView.PRRX2 is highly expressed in pancreatic cancer and correlates with patient prognosis. PRRX2 promotes pancreatic cancer cell proliferation, invasion, and metastasis, and inhibits pancreatic cancer cell senescence. PRRX2 transcriptionally regulates GLI2 and activates the Hedgehog pathway.
Wei Huang +7 more
wiley +1 more source
Highlighted article: “Indian Hedgehog Positively Regulates Calvarial Ossification and Modulates Bone Morphogenetic Protein Signaling” by K. Lenton, A. W. James, A. Manu, S. A. Brugmann, D. Birker, E. R. Nelson, P. Leucht, J. A. Helms and M. T. Longaker [PDF]
, 2011 openalex +1 more source