Hedgehog Signaling Modulates Glial Proteostasis and Lifespan
Cell Reports, 2020 Summary: The conserved Hedgehog signaling pathway has well-established roles in development. However, its function during adulthood remains largely unknown.
Andrew Rallis +6 more
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Mechanisms and therapeutic potential of the hedgehog signaling pathway in cancer [PDF]
Cell Death DiscoveryA sort of major malignant disease, cancer can compromise human health wherever. Some mechanisms of the occurrence and evolution of cancer still seem elusive even now. Consequently, the therapeutic strategies for cancer must continually evolve.
Ge Cong +4 more
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The Roles of Hedgehog Signaling Pathway in Radioresistance of Cervical Cancer
Dose-Response, 2019 Radiotherapy is an important treatment of cervical cancer, especially for advanced cervical cancer. According to research reports, Hedgehog signaling pathway plays an essential role in the growth, invasion, metastasis, recurrence, drug resistance, and ...
Chang Liu, Rensheng Wang
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A novel prognostic model for Hedgehog signaling pathway-related genes predicts the prognosis of hepatocellular carcinoma [PDF]
Frontiers in OncologyBackgroundThe Hedgehog signaling pathway is involved in the carcinogenesis and development of hepatocellular carcinoma(HCC); however, few studies on the prognostic model of the Hedgehog signaling pathway have been found.MethodsFirst, we selected 56 ...
Ting Liu, Yang Wang
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Fibrotic scar formation after cerebral ischemic stroke: Targeting the Sonic hedgehog signaling pathway for scar reduction [PDF]
Neural Regeneration ResearchRecent studies have shown that fibrotic scar formation following cerebral ischemic injury has varying effects depending on the microenvironment. However, little is known about how fibrosis is induced and regulated after cerebral ischemic injury.
Jun Wen +16 more
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Brain morphological analysis in mice with hyperactivation of the hedgehog signaling pathway [PDF]
Frontiers in NeuroscienceHedgehog signaling is a highly conserved pathway that plays pivotal roles in morphogenesis, tumorigenesis, osteogenesis, and wound healing. Previous investigations in patients with Gorlin syndrome found low harm avoidance traits, and increased volumes in
Tadashi Shiohama +18 more
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MYB Activates the Hedgehog Signaling Pathway to Repress Natural Killer Cytotoxicity in Cervical Cancer [PDF]
Kaohsiung Journal of Medical SciencesNatural killer (NK) cells present in the tumor microenvironment serve as a critical line of defense against various malignancies, including cervical cancer.
Yu Wang, Chen Li
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Cell Reports, 2017 Summary: Colon cancer is a heterogeneous tumor driven by a subpopulation of cancer stem cells (CSCs). To study CSCs in colon cancer, we used limiting dilution spheroid and serial xenotransplantation assays to functionally define the frequency of CSCs in ...
Joseph L. Regan +13 more
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Plexins promote Hedgehog signaling through their cytoplasmic GAP activity
eLife, 2022 Hedgehog signaling controls tissue patterning during embryonic and postnatal development and continues to play important roles throughout life. Characterizing the full complement of Hedgehog pathway components is essential to understanding its wide ...
Justine M Pinskey +7 more
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Cells, 2022 The Hedgehog signaling pathway regulates many processes during embryogenesis and the homeostasis of adult organs. Recent data suggest that central metabolic processes and signaling cascades in the liver are controlled by the Hedgehog pathway and that ...
Fritzi Ott +12 more
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