Results 21 to 30 of about 55,819 (299)
Hedgehog Signaling in Cortical Development [PDF]
, 2023 The Hedgehog (Hh) pathway plays a crucial role in embryonic development, acting both as a morphogenic signal that organizes tissue formation and a potent mitogenic signal driving cell proliferation.
Xuecai Ge +5 more
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Molecular Pathways: The Hedgehog Signaling Pathway in Cancer [PDF]
Clinical Cancer Research, 2012 AbstractThe Hedgehog (Hh) signaling pathway regulates embryonic development and may be aberrantly activated in a wide variety of human cancers. Efforts to target pathogenic Hh signaling have steadily progressed from the laboratory to the clinic, and the recent approval of the Hh pathway inhibitor vismodegib for patients with advanced basal cell ...
Ross, McMillan, William, Matsui
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The presynaptic glycine transporter GlyT2 is regulated by the Hedgehog pathway in vitro and in vivo
Communications Biology, 2021 By modulating the activation state of the Hedgehog pathway, de la Rocha-Muñoz et al demonstrate that Hedgehog signaling controls the expression and transport activity of the neuronal glycine transporter GlyT2.
Andrés de la Rocha-Muñoz +8 more
doaj +1 more source
The role of kinases in the Hedgehog signalling pathway [PDF]
EMBO reports, 2008 The Hedgehog (Hh) signalling pathway has a crucial role in several developmental processes and is aberrantly activated in a variety of cancers. In Drosophila , many of the canonical Hh pathway components are phosphorylated, yet the precise role of these phosphorylation events in the ...
Aikin, Reid A +2 more
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The Hedgehog signalling pathway in bone formation [PDF]
International Journal of Oral Science, 2015 The Hedgehog (Hh) signalling pathway plays many important roles in development, homeostasis and tumorigenesis. The critical function of Hh signalling in bone formation has been identified in the past two decades. Here, we review the evolutionarily conserved Hh signalling mechanisms with an emphasis on the functions of the Hh signalling pathway in bone ...
Yang, Jing +3 more
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Frontiers in Endocrinology, 2023 Hedgehog signaling plays pivotal roles in embryonic development, adult homeostasis and tumorigenesis. However, its engagement in the pituitary gland has been long underestimated although Hedgehog signaling and pituitary embryogenic development are ...
Yehan Bian, Heidi Hahn, Anja Uhmann
doaj +1 more source
Hedgehog inhibition promotes a switch from Type II to Type I cell death receptor signaling in cancer cells. [PDF]
PLoS ONE, 2011 TRAIL is a promising therapeutic agent for human malignancies. TRAIL often requires mitochondrial dysfunction, referred to as the Type II death receptor pathway, to promote cytotoxicity.
Satoshi Kurita +8 more
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Role of Hedgehog Signaling Pathway in NASH [PDF]
International Journal of Molecular Sciences, 2016 Non-alcoholic fatty liver disease (NAFLD) is the number one cause of chronic liver disease in the Western world. Although only a minority of patients will ultimately develop end-stage liver disease, it is not yet possible to efficiently predict who will progress and, most importantly, effective treatments are still unavailable.
Verdelho Machado, Mariana +1 more
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Hedgehog signaling pathway and gastric cancer [PDF]
Cancer Biology & Therapy, 2005 Hedgehog, WNT, FGF and BMP signaling pathways network together during embryogenesis, tissue regeneration, and carcinogenesis. Aberrant activation of Hedgehog signaling pathway leads to pathological consequences in a variety of human tumors, such as gastric cancer and pancreatic cancer.
Yuriko, Katoh, Masaru, Katoh
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Hedgehog Signaling: An Achilles’ Heel in Cancer
Translational Oncology, 2019 Hedgehog signaling pathway originally identified in the fruit fly Drosophila is an evolutionarily conserved signaling mechanism with crucial roles in embryogenesis, growth and patterning. It exerts its biological effect through a signaling mechanism that
Madiha Niyaz +2 more
doaj +1 more source