Results 41 to 50 of about 55,819 (299)
Drugging Hedgehog: signaling the pathway to translation [PDF]
BMC Biology, 2013 First discovered in Drosophila, the Hedgehog signaling pathway controls a wide range of developmental processes and is implicated in a variety of cancers. The success of a screen for chemical modulators of this pathway, published in 2002, opened a new chapter in the quest to translate the results of basic developmental biology research into therapeutic
Carney, Tom J, Ingham, Philip W
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The transcriptional activator Gli2 modulates T-cell receptor signalling through attenuation of AP-1 and NFκ-B activity. [PDF]
, 2015 Different tissues contain diverse and dynamic cellular niches, providing distinct signals to tissue-resident or migratory, infiltrating immune cells.
Lau, Ching-In +18 more
core +1 more source
RETRACTED: TMEM107 inhibits EMT and invasion of NSCLC through regulating the Hedgehog pathway
Thoracic Cancer, 2021 Background Transmembrane protein 107 (TMEM107) is a key regulator of the cilium composition and Hedgehog signaling. Lower TMEM107 gene copies are correlated with poor prognosis in non‐small cell lung carcinoma (NSCLC). However, TMEM107 protein expression,
Huihui Xu +5 more
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Prostate cancer and Hedgehog signalling pathway [PDF]
Clinical and Translational Oncology, 2007 The Hedgehog (Hh) family of intercellular signalling proteins have come to be recognised as key mediators in many fundamental processes in embryonic development. Their activities are central to the growth, patterning and morphogenesis of many different regions within the bodies of vertebrates.
Antón-Aparicio, Luis M. +6 more
openaire +3 more sources
Research progress on the mechanism of the Hedgehog signaling pathway during mandibular development [PDF]
口腔疾病防治The source and process of mandible development are significantly different from those of other bones in the body, and abnormal development can lead to various bone-related diseases, seriously affecting the quality of life of patients.
XU Yao, LI Wenjin
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Activation of the hedgehog pathway in advanced prostate cancer
Molecular Cancer, 2004 Background The hedgehog pathway plays a critical role in the development of prostate. However, the role of the hedgehog pathway in prostate cancer is not clear. Prostate cancer is the second most prevalent cause of cancer death in American men. Therefore,
McCormick Frank +8 more
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Super-enhancer hijacking drives ectopic expression of hedgehog pathway ligands in meningiomas
Nature Communications, 2023 Hedgehog signaling mediates embryologic development of the central nervous system and other tissues and is frequently hijacked by neoplasia to facilitate uncontrolled cellular proliferation.
Mark W. Youngblood +36 more
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Identification of a potent antagonist of smoothened in hedgehog signaling
Cell & Bioscience, 2021 Background Hedgehog signaling is essential to the regulation of embryonic development, tissue homeostasis, and stem cell self-renewal, making it a prime target for developing cancer therapeutics.
Junwan Fan +8 more
doaj +1 more source
, 2020 An abnormality in hedgehog (Hh) signaling has been implicated in the progression of prostate cancer (PCa) to a more aggressive and therapy-resistant disease.
Santosh Kumar Singh +5 more
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Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation
, 2009 We show that Indian Hedgehog (Ihh) regulates T-cell development and homeostasis in both fetal and adult thymus, controlling thymocyte number. Fetal Ihh-/- thymi had reduced differentiation to double-positive (DP) cell and reduced cell numbers compared ...
Outram, Susan V +17 more
core +1 more source