Results 31 to 40 of about 55,819 (299)

Gli1 mediates lung cancer cell proliferation and sonic hedgehog-dependent mesenchymal cell activation. [PDF]

, 2013
Non-Small-Cell-Lung-Cancer (NSCLC) represents approximately 85% of all lung cancers and remains poorly understood. While signaling pathways operative during organ development, including Sonic Hedgehog (Shh) and associated Gli transcription factors (Gli1 ...
Hennen, Elisabeth, Olga Bermudez, Oliver Eickelberg, Olga Bermudez (410727), Ina Koch (7903), Oliver Eickelberg (153848), Eickelberg, O., Bermudez, O., Koch, I., Lindner, Michael, Elisabeth Hennen, Hennen, E., Koch, Ina, Elisabeth Hennen (410728), Bermudez, Olga, Michael Lindner, Ina Koch, Michael Lindner (383308), Lindner, M., Eickelberg, Oliver   +19 more
core   +1 more source

Hedgehog Signaling Pathway and Autophagy in Cancer [PDF]

International Journal of Molecular Sciences, 2018
Hedgehog (Hh) pathway controls complex developmental processes in vertebrates. Abnormal activation of Hh pathway is responsible for tumorigenesis and maintenance of multiple cancers, and thus addressing this represents promising therapeutic opportunities. In recent years, two Hh inhibitors have been approved for basal cell carcinoma (BCC) treatment and
Zeng, X., Ju, D.
openaire   +3 more sources

Molecular Characterization of the Hedgehog Signaling Pathway and Its Necessary Function on Larval Myogenesis in the Pacific Oyster Crassostrea gigas

Frontiers in Physiology, 2018
Hedgehog signaling pathway participates in a chain of necessary physiological activities and dysregulation of the hedgehog signaling has been implicated in birth defects and diseases.
Huijuan Li, Qi Li, Qi Li, Hong Yu, Hong Yu   +4 more
doaj   +1 more source

Primary cilia disassembly down regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes [PDF]

, 2014
SummaryObjectiveHedgehog signalling is mediated by the primary cilium and promotes cartilage degeneration in osteoarthritis. Primary cilia are influenced by pathological stimuli and cilia length and prevalence are increased in osteoarthritic cartilage ...
Knight, M.M., Chapple, JP, Chapple, J.P., Knight, MM, Thompson, CL, Thompson, C.L.   +5 more
core   +1 more source

The Hedgehog signalling pathway regulates autophagy [PDF]

Nature Communications, 2012
Autophagy is a highly conserved degradative process that removes damaged or unnecessary proteins and organelles, and recycles cytoplasmic contents during starvation. Autophagy is essential in physiological processes such as embryonic development but how autophagy is regulated by canonical developmental pathways is unclear.
Jimenez-Sanchez, Maria, Menzies, Fiona M., Chang, Yu Yun, Simecek, Nikol, Neufeld, Thomas P., Rubinsztein, David C.   +5 more
openaire   +4 more sources

The hedgehog signalling pathway in tumorigenesis and development [PDF]

Oncogene, 1999
The hedgehog signalling pathway is responsible for the embryonic patterning of a range of tissues, and it is now known that dysregulation of this pathway can result in the formation of several tumour types. This cascade is regulated at the cell surface by the opposing actions of the patched and smoothened molecules which together form a receptor ...
Wicking, Carol, Smyth, Ian, Bale, Allen
openaire   +6 more sources

Hedgehog signaling pathway as a potential target in the treatment of advanced gastric cancer

Tumor Biology, 2017
The sonic hedgehog signaling pathway is critical for cell proliferation, cell differentiation, and organ development during embryogenesis. Aberrant activation of the sonic hedgehog pathway has been associated with a variety of human cancers.
Dae-Hee Lee, Suk-young Lee, Sang Cheul Oh   +2 more
doaj   +1 more source

Expression of Sonic Hedgehog and pathway components in the embryonic mouse head: anatomical relationships between regulators of positive and negative feedback

BMC Research Notes, 2021
Objective The Hedgehog pathway is a fundamental signaling pathway in organogenesis. The expression patterns of the ligand Sonic Hedgehog (Shh) and key pathway components have been studied in many tissues but direct spatial comparisons across tissues with
Crystal L. Sigulinsky, Xiaodong Li, Edward M. Levine   +2 more
doaj   +1 more source

Activation of hedgehog signaling is not a frequent event in ovarian cancers

Molecular Cancer, 2009
The hedgehog (Hh) signaling pathway regulates many processes of development and tissue homeostasis. Activation of hedgehog signaling has been reported in about 30% of human cancer including ovarian cancer.
Zhang Xiaoli, Huang Shuhong, He Jing, Yang Ling, Bian Yuehong, He Nonggao, Zhang Hongwei, Xie Jingwu   +7 more
doaj   +1 more source

Hippo signaling activates hedgehog signaling by Taz-driven Gli3 processing

Cell Regeneration, 2023
The overlapping roles of Hippo and Hedgehog signaling in biological functions and diseases prompt us to investigate their potential interactions. Activation of Hippo signaling enhances the transcriptional output of Hedgehog signaling, and the role of ...
Chao Tang, Jirong Wang, Minli Yao, Xing Ji, Wei Shi, Chengyun Xu, Ling-Hui Zeng, Ximei Wu   +7 more
doaj   +1 more source