Results 11 to 20 of about 55,819 (299)
The hedgehog signaling pathway in ischemic tissues [PDF]
International Journal of Molecular Sciences, 2019 Hedgehog (Hh) proteins are prototypical morphogens known to regulate epithelial/mesenchymal interactions during embryonic development. In addition to its pivotal role in embryogenesis, the Hh signaling pathway may be recapitulated in post-natal life in a
Pola R. +3 more
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Hedgehog Signaling Pathway in Ovarian Cancer [PDF]
International Journal of Molecular Sciences, 2013 Despite advances in surgical and chemotherapeutic treatment options, less than 50% of patients with advanced-stage ovarian cancer survive five years after initial diagnosis.
Gerger, Armin +9 more
core +5 more sources
Hedgehog Signaling Pathway and Lung Cancer [PDF]
Journal of Thoracic Oncology, 2007 Signaling pathways responsible for embryogenesis play a critical role in the maintenance of stem cells in adult life and cellular responses to injury. Dysfunction of the developmental signaling pathways during adult homeostasis leads to various events ...
Velcheti, Vamsidhar, Govindan, Ramaswamy
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The emerging roles of phosphatases in Hedgehog pathway [PDF]
Cell Communication and Signaling, 2017 Hedgehog signaling is evolutionarily conserved and plays a pivotal role in cell fate determination, embryonic development, and tissue renewal. As aberrant Hedgehog signaling is tightly associated with a broad range of human diseases, its activities must ...
Long Zhao +4 more
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Recent Advances in the Clinical Targeting of Hedgehog/GLI Signaling in Cancer
Cells, 2019 The Hedgehog/GLI signaling pathway plays an important role in normal embryonic tissue development and has been implicated in the pathogenesis of various human cancers.
Hao Xie +3 more
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Clinical implications of hedgehog signaling pathway inhibitors
Chinese Journal of Cancer, 2011 Hedgehog was first described in Drosophila melanogaster by the Nobel laureates Eric Wieschaus and Christiane Nüsslein-Volhard. The hedgehog (Hh) pathway is a major regulator of cell differentiation, proliferation, tissue polarity, stem cell maintenance ...
Hailan Liu +5 more
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Lipid metabolism fattens up hedgehog signaling
BMC Biology, 2017 Signaling pathways direct organogenesis, often through concentration-dependent effects on cells. The hedgehog pathway enables cells to sense and respond to hedgehog ligands, of which the best studied is sonic hedgehog. Hedgehog signaling is essential for
Robert Blassberg, John Jacob
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Research progress on the role of Hedgehog signaling pathway in renal interstitial fibrosis
Linchuang shenzangbing zazhi, 2020 Renal interstitial fibrosis is the common progressive pathway for many chronic kidney diseases.The activation of Hedgehog signaling pathway seems to play an important role in progression of chronic kidney diseases as much as in embryonic renal ...
ZHOU Lan-qi, ZHOU Jian-hua
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The Hedgehog Signaling Pathway in Cancer [PDF]
Clinical Cancer Research, 2006 AbstractThe Hedgehog (Hh) pathway is a signaling cascade that directs patterning in most animals and is crucial for proper development. At the molecular level, Hh ligands drive cell proliferation in some cell types while causing others to undergo differentiation. Hh signaling is most active during embryogenesis, and aberrant reactivation of the pathway
Marie, Evangelista +2 more
openaire +3 more sources
The you gene encodes an EGF-CUB protein essential for Hedgehog signaling in zebrafish. [PDF]
PLoS Biology, 2005 Hedgehog signaling is required for many aspects of development in vertebrates and invertebrates. Misregulation of the Hedgehog pathway causes developmental abnormalities and has been implicated in certain types of cancer.
Ian G Woods, William S Talbot
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