Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on SHH (Sonic hedgehog), with data on DNA, on the protein encoded, and where the gene is implicated.
Magnaldo, T
exaly +3 more sources
Regulation of Cholesterol Binding to the Receptor Patched1 by its interactions With the Ligand Sonic Hedgehog (Shh) [PDF]
Frontiers in Molecular Biosciences, 2022 The Hedgehog (Hh) signaling pathway is essential in cell development and regeneration, which is activated by the ligand Sonic hedgehog (Shh). The binding of Shh to its receptor Patched1 (PTCH1) releases the inhibitory effect on the downstream protein ...
Changqing Zhong, Beibei Wang
doaj +5 more sources
HHIPL2 positively governs Hedgehog signaling to accelerate non-small cell lung cancer progression via enhancing HNRNPC-mediated HNF1A mRNA stabilization [PDF]
Cell Death and DiseaseSonic Hedgehog signaling is aberrantly activated in non-small cell lung cancer (NSCLC). However, the regulatory molecules of Sonic Hedgehog signaling during NSCLC development are still largely unknown. Here, we demonstrated that HHIP Like 2 (HHIPL2) is a
Ning Mu +14 more
doaj +2 more sources
Palatogenesis: The role of Sonic hedgehog (Shh) signaling in the secondary palate development
Sakarya Tıp Dergisi, 2022 Palatogenesis is a complicated and precisely balanced process in which malfunctions induce congenital cleft palate, one of the most common embryonic developmental anomaly seen in newborns.
Elvan Şahin, Reem Al-towaitee
doaj +4 more sources
MB-36WIP1 AUGMENTS SONIC HEDGEHOG (SHH) SIGNALING AND IS A TARGET IN SHH MEDULLOBLASTOMAS [PDF]
Neuro Oncol, 2015 Sonic Hedgehog (SHH) signaling is active in 30% of childhood medulloblastomas. Dysregulation of p53 signaling is especially prognostic for poor survival in SHH medulloblastoma. But, p53 is mutated in
Lee J +5 more
europepmc +3 more sources
RING1B-BMI1 catalyzed dynamic H2AK119ub1 modification in response to sonic hedgehog signalling during pancreatic differentiation of human embryonic stem cells [PDF]
Scientific ReportsHuman embryonic stem cells (ESCs) can differentiate into the pancreatic lineage and thus can serve as in vitro models for normal pancreas development.
Niloufer P. Dumasia, Prasad S. Pethe
doaj +2 more sources
Canonical Sonic Hedgehog Signaling in Early Lung Development
Journal of Developmental Biology, 2017 The canonical hedgehog (HH) signaling pathway is of major importance during embryonic development. HH is a key regulatory morphogen of numerous cellular processes, namely, cell growth and survival, differentiation, migration, and tissue polarity. Overall,
Hugo Fernandes-Silva +2 more
exaly +3 more sources
RUNX3 gene expression confers an independent Overall survival advantage in non-M3 adult acute myeloid leukemia patients in Egypt. [PDF]
Egyptian Journal of Cancer and Biomedical Research, 2020 Pretreatment bone marrow samples from 46 newly diagnosed acute myeloid leukemia (AML) patients were analyzed by qRT-PCR. The aim of the present study was to evaluate mRNA expression of RUNX1,2 and 3 along with the hedgehog ligands Indian hedgehog(IHH ...
Nagwa Hassan +4 more
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Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling
Nature Communications, 2021 Hedgehog-Interacting Protein (HHIP) is the only reported secreted inhibitor of Sonic Hedgehog (SHH) signalling. Here, the authors report structures of the HHIP N- and C-terminal domains, both in complexes with glycosaminoglycans, providing insights into ...
Samuel C. Griffiths +11 more
doaj +1 more source
The transcriptional landscape of Shh medulloblastoma
Nature Communications, 2021 Sonic Hedgehog medulloblastoma (Shh-MB) comprises four subtypes each with distinct clinical traits. Here the authors characterize the genome, transcriptome, and methylome of Shh-MB subtypes, revealing a complex fusion landscape and the molecular ...
Patryk Skowron +98 more
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