Results 41 to 50 of about 26,431 (247)

Proteomic analysis of human sonic hedgehog (SHH) medulloblastoma stem-like cells [PDF]

Molecular BioSystems, 2015
Abstract Human medulloblastoma (MB) is a malignant brain tumor that comprises four distinct molecular subgroups including the Sonic Hedgehog (SHH)-MB group. A leading cause of the SHH subgroup is an aberrant activation of the SHH pathway, a developmental signaling that regulates postnatal development of the cerebellum by promoting the
Ronci, Maurizio, CATANZARO, GIUSEPPINA, Pieroni, Luisa, PO, AGNESE, BESHARAT, ZEIN MERSINI, Greco, Viviana, LEVI MORTERA, STEFANO, SCREPANTI, Isabella, FERRETTI, ELISABETTA, Urbani, Andrea   +9 more
openaire   +2 more sources

Comparative and evolutionary analysis of the reptilian hedgehog gene family (Shh, Dhh, and Ihh) [PDF]

PeerJ, 2019
The hedgehog signaling pathway plays a vital role in human and animal patterning and cell proliferation during the developmental process. The hedgehog gene family of vertebrate species includes three genes, Shh, Dhh, and Ihh, which possess different ...
Tian Xia, Honghai Zhang, Lei Zhang, Xiufeng Yang, Guolei Sun, Jun Chen, Dajie Xu, Chao Zhao   +7 more
doaj   +2 more sources

Exploring new targeted therapies for sonic hedgehog (SHH) medulloblastoma

Medulloblastoma (MB) is the most common malignant primary pediatric brain tumor. MB is split into four molecular subgroups, with each subgroup displaying different gene expression profiles, genomic alterations, and responses to treatment. One subgroup is referred to as Sonic Hedgehog (SHH) MB and is defined by activation of the SHH signaling pathway ...
Cheetham, Stephanie
openaire   +2 more sources

Temporal-spatial changes in Sonic Hedgehog expression and signaling reveal different potentials of ventral mesencephalic progenitors to populate distinct ventral midbrain nuclei

, 2011
Background: The ventral midbrain contains a diverse array of neurons, including dopaminergic neurons of the ventral tegmental area (VTA) and substantia nigra (SN) and neurons of the red nucleus (RN).
Joyner, Alexandra L., Stephen Daniel, Chanet, S., Chanet, Soline, Blaess, S., Emilie Mugniery, Sandra Blaess, Joyner, L., Daniel Stephen, Soline Chanet, Mugniery, E., Kabanova, Anna, Bodea, G., Blaess, Sandra, Derouiche, Amin, Alexandra L Joyner, Mugniery Emilie, Gabriela O Bodea, Chanet Soline, Joyner, Alexandra, Joyner Alexandra L, Bodea, Gabriela O., Mugniery, Emilie, Derouiche, A., Blaess Sandra, Stephen, D., Kabanova, A., Derouiche Amin, Bodea Gabriela O, Bodea, Gabriela, Kabanova Anna, Anna Kabanova, Stephen, Daniel, Amin Derouiche   +33 more
core   +1 more source

Baicalin Attenuates Alcoholic Liver Injury through Modulation of Hepatic Oxidative Stress, Inflammation and Sonic Hedgehog Pathway in Rats

Cellular Physiology and Biochemistry, 2016
Background/Aims: Lipid accumulation, inflammatory responses and oxidative stress have been implicated in the pathology of alcoholic liver disease (ALD). Targeting inhibition of these features may provide a promising therapeutic strategy for ALD. Baicalin,
Huifen Wang, Yanli Zhang, Ruxue Bai, Miao Wang, Shiyu Du   +4 more
doaj   +1 more source

Attenuation of hedgehog acyltransferase-catalyzed sonic Hedgehog palmitoylation causes reduced signaling, proliferation and invasiveness of human carcinoma cells.

PLoS ONE, 2014
Overexpression of Hedgehog family proteins contributes to the aetiology of many cancers. To be highly active, Hedgehog proteins must be palmitoylated at their N-terminus by the MBOAT family multispanning membrane enzyme Hedgehog acyltransferase (Hhat ...
Antonios D Konitsiotis, Shu-Chun Chang, Biljana Jovanović, Paulina Ciepla, Naoko Masumoto, Christopher P Palmer, Edward W Tate, John R Couchman, Anthony I Magee   +8 more
doaj   +1 more source

The hedgehog/Gli-1 signaling pathways is involved in the inhibitory effect of resveratrol on human colorectal cancer HCT116 cells [PDF]

Iranian Journal of Basic Medical Sciences, 2016
Objective(s): The study aimed to investigate the effects of resveratrol on colorectal cancer HCT116 cells, including cell viability, apoptosis, and migration, and the partial mechanisms focused on hedgehog/gli-1 signaling pathways. Materials and Methods:
Zhou Du, Feng Zhou, Zengrong Jia, Beishi Zheng, Shaoliang Han, Jun Cheng, Guanbao Zhu, Ping Huang   +7 more
doaj   +1 more source

Effect of sonic hedgehog/β-TCP composites on bone healing within the critical-sized rat femoral defect

, 2013
The creation of entirely synthetically derived bone substitute materials which are as effective as autologous bone grafts is desirable. Osteogenesis involves the concerted action of several proteins within a signaling cascade.
Henrich, Dirk, Marzi, Ingo, Seebach, Caroline, Flinspach, Armin Niklas, Wenger, Florian, Warzecha, Jörg   +5 more
core   +1 more source

The role of Sulf1 during Sonic hedgehog mediated neural patterning [PDF]

, 2011
Heparan sulphate proteoglycans (HSPGs) are large molecules distributed ubiquitously, both at the cell surface and within the extracellular matrix. These molecules are known to play essential roles in developmental cell signalling, and the differential ...
Ramsbottom, Simon A, Ramsbottom, Simon.A
core  

Mapping the Shh long-range regulatory domain

, 2014
Coordinated gene expression controlled by long-distance enhancers is orchestrated by DNA regulatory sequences involving transcription factors and layers of control mechanisms.
Hill, Robert E, Devenney, Paul S, Lettice, Laura A, Anderson, Eve   +3 more
core   +1 more source