Results 51 to 60 of about 26,431 (247)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Sulforaphane inhibits self-renewal of lung cancer stem cells through the modulation of sonic Hedgehog signaling pathway and polyhomeotic homolog 3

AMB Express, 2021
Sulforaphane (SFN), an active compound in cruciferous vegetables, has been characterized by its antiproliferative capacity. We investigated the role and molecular mechanism through which SFN regulates proliferation and self-renewal of lung cancer stem ...
Fanping Wang, Yanwei Sun, Xiaoyu Huang, Caijuan Qiao, Wenrui Zhang, Peijun Liu, Mingyong Wang   +6 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Monorail/Foxa2 regulates floorplate differentiation and specification of oligodendrocytes, serotonergic raphe neurones and cranial motoneurones [PDF]

, 2005
In this study, we elucidate the roles of the winged-helix transcription factor Foxa2 in ventral CNS development in zebrafish. Through cloning of monorail (mol), which we find encodes the transcription factor Foxa2, and phenotypic analysis of mol ...
Schilling, TF, Geisler, Robert, Norton, W H, Houart, Corinne, Diamond, B, Mangoli, Maryam, Brianne Diamond, Rees, M., Stephen W. Wilson, Strähle, U., Talbot, W., Norton, W., Diamond, B., Schilling, T., William S. Talbot, Gerd-Jörg Rauch, Frohnhoefer, Hans-Georg, Talbot, WS, Max Planck, Forschungszentrum Karlsruhe, Carl-Philipp Heisenberg, Mercurio, S., Heisenberg, C., Diamond, Brianne, Claire Russell, Pogoda, H., Geisler, R. ; https://orcid.org/, Sara Mercurio, Stickney, Heather L, Neumann, CJ, Heisenberg, C P, Mercurio, Sara, Maryam Mangoli, Gardiner, R M, Stickney, HL, Neumann, C J, Zsolt Lele, Frohnhoefer, HG, Norton, Will H, Sepand Rastegar, Russell, C., Pogoda, HM, Stanford University, Wilson, Stephen W, Will H. Norton, Hans-Georg Frohnhoefer, Neumann, Carl J, Neumann, C., Norton, WH, Rauch, Gerd-Jörg, Geisler, R, Heisenberg, Carl-Philipp, Heather L. Stickney, Schilling, T F, Stickney, H., UCL, Lele, Z, Mangoli, M., Uwe Strähle, Wilson, SW, Russell, C, Rauch, G., Pogoda, H M, R. Mark Gardiner, Gardiner, R., Carl J. Neumann, Houart , C., Rastegar, S., Pogoda, Hans-Martin, Thomas F. Schilling, Rees, M, Houart, C, Mangoli, M, Teraoka, Hiroki, Gardiner, RM, Rastegar, Sepand, Wilson, S., Teraoka, H, Strahle, U, Heidelberg, Frohnhoefer, H G, Rastegar, S, Gardiner, R Mark, Hiroki Teraoka, Lele, Z., Russell, Claire, Rees, Michelle, Robert Geisler, Lele, Zsolt, Heisenberg, CP, Stickney, H L, Hans-Martin Pogoda, Corinne Houart, Talbot, W S, Wilson, S W, Inserm, Paris, Rauch, G J, Schilling, Thomas F, Frohnhöfer, H. ; https://orcid.org/, Michelle Rees, Strähle, Uwe, Rauch, GJ, Teraoka, H., Mercurio, S, Talbot, William S   +104 more
core   +1 more source

An Accessible Microfluidic Platform for the Generation of Polarized Brain Organoids

Advanced Materials Technologies, EarlyView.
This study presents an accessible double‐gradient microfluidic device that enables controlled morphogen delivery and spatially polarized differentiation in brain organoids. By integrating a pump‐free design and stable fabrication method, the platform generates dorsal–ventral neuronal asymmetry, offering a reproducible and versatile approach to model ...
Daniel Pérez‐Calixto, Manuel Alejandro Vazquez Valle, Mitzi Pérez‐Calixto, Cindy Peto‐Gutiérrez, Iván Velasco, Genaro Vázquez‐Victorio, Itzel Escobedo‐Avila   +6 more
wiley   +1 more source

Sonic hedgehog is basolaterally sorted from the TGN and transcytosed to the apical domain involving Dispatched-1 at Rab11-ARE

Frontiers in Cell and Developmental Biology, 2022
Hedgehog proteins (Hhs) secretion from apical and/or basolateral domains occurs in different epithelial cells impacting development and tissue homeostasis.
Lisette Sandoval, Mariana Labarca, Mariana Labarca, Claudio Retamal, Claudio Retamal, Paula Sánchez, Juan Larraín, Alfonso González, Alfonso González, Alfonso González   +9 more
doaj   +1 more source

Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair

Advanced Science, EarlyView.
Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li, Xin Xing, Beicheng Du, Myles Zhou, Austin Z. Chen, Mary Archer, Chunbao Rao, Manyu Zhu, Masnsen Cherief, Aaron W. James   +9 more
wiley   +1 more source

Expression of GNAS, TP53, and PTEN Improves the Patient Prognostication in Sonic Hedgehog (SHH) Medulloblastoma Subgroup [PDF]

The Journal of Molecular Diagnostics, 2020
Medulloblastoma (MB) is the most common malignant brain tumor in children. It is currently classified in four main molecular subgroups with different clinical outcomes: sonic hedgehog, wingless, group 3, and group 4 (MBSHH, MBWNT, MBGRP3, or MBGRP4).
Luciane S. da Silva, Bruna M. Mançano, Flávia E. de Paula, Mariana B. dos Reis, Gisele C. de Almeida, Marcus Matsushita, Carlos A. Junior, Adriane F. Evangelista, Fabiano Saggioro, Luciano N. Serafini, João N. Stavale, Suzana M.F. Malheiros, Matheus Lima, Glaucia N.M. Hajj, Marcos A. de Lima, Michael D. Taylor, Letícia F. Leal, Rui M. Reis   +17 more
openaire   +2 more sources

Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation

, 2009
We show that Indian Hedgehog (Ihh) regulates T-cell development and homeostasis in both fetal and adult thymus, controlling thymocyte number. Fetal Ihh-/- thymi had reduced differentiation to double-positive (DP) cell and reduced cell numbers compared ...
Outram, Susan V, Ross, Susan E, Rowbotham, Nicola J, Crompton, T, Hager-Theodorides, Ariadne L, Shah, DK, Shah, Divya K, Drakopoulou, Ekati, Lanske, Beate, Crompton, Tessa, Dessens, Johannes T, Drakopoulou, E, Rowbotham, NJ, Dessens, JT, Ross, SE, Lanske, B, Outram, SV, Hager-Theodorides, AL   +17 more
core   +1 more source

Stromal Regulation of Tumor Perineural Invasion: A Multicellular and Neuro‐Ecological Perspective

Advanced Science, EarlyView.
This review reframes perineural invasion (PNI) as a dynamic, multicellular process within the tumor–nerve–stromal ecosystem. The authors delineate how cancer‐associated fibroblasts, Schwann cells, and immune cells remodel the neural niche to facilitate tumor spread.
Xiaoyang Lin, Yingqiao Liu, Haitao Lin, Kang Feng, Xiqiang Liu   +4 more
wiley   +1 more source