Results 31 to 40 of about 26,431 (247)

The Ciliary Protein Arl13b Functions Outside of the Primary Cilium in Shh-Mediated Axon Guidance

Cell Reports, 2019
Summary: The small GTPase Arl13b is enriched in primary cilia and regulates Sonic hedgehog (Shh) signaling. During neural development, Shh controls patterning and proliferation through a canonical, transcription-dependent pathway that requires the ...
Julien Ferent, Sandii Constable, Eduardo D. Gigante, Patricia T. Yam, Laura E. Mariani, Emilie Legué, Karel F. Liem, Jr., Tamara Caspary, Frédéric Charron   +8 more
doaj   +1 more source

Expression of Sonic Hedgehog and pathway components in the embryonic mouse head: anatomical relationships between regulators of positive and negative feedback

BMC Research Notes, 2021
Objective The Hedgehog pathway is a fundamental signaling pathway in organogenesis. The expression patterns of the ligand Sonic Hedgehog (Shh) and key pathway components have been studied in many tissues but direct spatial comparisons across tissues with
Crystal L. Sigulinsky, Xiaodong Li, Edward M. Levine   +2 more
doaj   +1 more source

Sonic hedgehog signaling: Alternative splicing and pathogenic role in medulloblastoma

Genes and Diseases, 2023
Alternative splicing (AS) produces the different mRNA splicing bodies, which are then translated into multiple protein isoforms and participate in various biological functions.
Meiyu Qu, Qiangqiang He, Jiahao Luo, Tingyu Shen, Ruibo Gao, Yana Xu, Chengyun Xu, Muhammad Qasim Barkat, Ling-Hui Zeng, Ximei Wu   +9 more
doaj   +1 more source

Genome-wide identification of Hand2 target regions in mouse embryos using dRMCE, a new genetic tool [PDF]

, 2012
Limb bud development is a paradigmatic model to study the molecular signals that orchestrate cell growth and behaviour. Anterior-posterior patterning of the limb bud mesenchyme is dependent on the secreted ligand Sonic hedgehog (Shh).
Osterwalder, Marco
core   +1 more source

Epithelial cells supply Sonic Hedgehog to the perinatal dentate gyrus via transport by platelets

eLife, 2015
Dentate neural stem cells produce neurons throughout life in mammals. Sonic hedgehog (Shh) is critical for maintenance of these cells; however, the perinatal source of Shh is enigmatic.
Youngshik Choe, Trung Huynh, Samuel J Pleasure   +2 more
doaj   +1 more source

The transcriptional activator Gli2 modulates T-cell receptor signalling through attenuation of AP-1 and NFκ-B activity. [PDF]

, 2015
Different tissues contain diverse and dynamic cellular niches, providing distinct signals to tissue-resident or migratory, infiltrating immune cells.
Lau, Ching-In, Barbarulo, Alessandro, Crompton, T, Barbarulo, A, Saldana, JI, Sahni, H, D'Acquisto, Fulvio, Solanki, Anisha, Sahni, Hemant, Crompton, Tessa, D'Acquisto, F, Saldana, Jose Ignacio, Solanki, A, Lau, C-I, D’Acquisto, Fulvio, Furmanski, AL, Furmanski, Anna L, Lau, CI, Furmanski, Anna   +18 more
core   +1 more source

Epigenetic regulation of mammalian Hedgehog signaling to the stroma determines the molecular subtype of bladder cancer

eLife, 2019
In bladder, loss of mammalian Sonic Hedgehog (Shh) accompanies progression to invasive urothelial carcinoma, but the molecular mechanisms underlying this cancer-initiating event are poorly defined.
SungEun Kim, Yubin Kim, JungHo Kong, Eunjee Kim, Jae Hyeok Choi, Hyeong Dong Yuk, HyeSun Lee, Hwa-Ryeon Kim, Kyoung-Hwa Lee, Minyong Kang, Jae-Seok Roe, Kyung Chul Moon, Sanguk Kim, Ja Hyeon Ku, Kunyoo Shin   +14 more
doaj   +1 more source

Interlinked signaling feedback loops and self-regulation during vertebrate limb development [PDF]

, 2009
Reliable organ and tissue morphogenesis seems to depend on self-regulatory mechanisms that are able to buffer spontaneous and/or genetic variations. While the analysis of the interactions of BMPs with their antagonists during gastrulation has provided ...
Bénazet, Jean-Denis
core   +1 more source

Sonic hedgehog improves redifferentiation of dedifferentiated chondrocytes for articular cartilage repair.

PLoS ONE, 2014
Sonic hedgehog (Shh) is involved in the induction of early cartilaginous differentiation of mesenchymal cells in the limb. We investigated whether Shh could promote redifferentiation of dedifferentiated chondrocytes and have a favorable effect on the ...
Lin Lin, Qi Shen, Tao Xue, Xiaoning Duan, Xin Fu, Changlong Yu   +5 more
doaj   +1 more source

Role of the ANKMY2-FKBP38 Axis in Regulation of the Sonic Hedgehog (Shh) Signaling Pathway [PDF]

Journal of Biological Chemistry, 2014
Sonic hedgehog (Shh) is a secreted morphogen that controls the patterning and growth of various tissues in the developing vertebrate embryo, including the central nervous system. Ablation of the FK506-binding protein 38 (FKBP38) gene results in activation of the Shh signaling pathway in mouse embryos, but the molecular mechanism by which FKBP38 ...
Shotaro, Saita, Michiko, Shirane, Tohru, Ishitani, Nobuyuki, Shimizu, Keiichi I, Nakayama   +4 more
openaire   +2 more sources