Results 11 to 20 of about 26,431 (247)
Immunolocalization of Sonic Hedgehog (Shh) in Developing Mouse Lung [PDF]
Journal of Histochemistry & Cytochemistry, 2001 Expression of sonic hedgehog (Shh) is required for normal development of the lung during embryogenesis. Loss of Shh expression in mice results in tracheoesophageal fistula, lung hypoplasia, and abnormal lung lobulation. To determine whether Shh may play a role later in lung morphogenesis, immunostaining for Shh was performed in mouse lung from ...
L A, Miller, S E, Wert, J A, Whitsett
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Regulation of Sonic hedgehog (Shh) expression in the zebrafish retina [PDF]
, 2007 Sonic hedgehog (Shh) a vertebrate homolog of the Drosophila melanogaster gene hedgehog, is a secreted protein that controls numerous differentiation processes during vertebrate development. In the vertebrate retina, Shh controls neurogenesis and its expression spreads in a wave like manner.
Rathnam, Saradavey
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Sonic hedgehog signaling in epithelial tissue development
Regenerative Medicine Research, 2019 The Sonic hedgehog (SHH) signaling pathway is essential for embryonic development and tissue regeneration. The dysfunction of SHH pathway is involved in a variety of diseases, including cancer, birth defects, and other diseases.
Zheng Lu +5 more
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Autocrine Sonic hedgehog attenuates inflammation in cerulein-induced acute pancreatitis in mice via upregulation of IL-10. [PDF]
PLoS ONE, 2012 Hedgehog signaling plays critical roles in pancreatic oncogenesis and chronic pancreatitis, but its roles in acute pancreatitis (AP) are largely ambiguous.
Xiangyu Zhou +5 more
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Nature Communications, 2022 Long non-coding RNAs (lncRNAs) can contribute to cancers that are driven by Sonic hedgehog (SHH) signaling. Here the authors report that lncRNA HHIP-AS1 stabilises the mRNA of dynein complex 1, thereby, promoting the pro-mitotic effects of SHH-driven ...
Jasmin Bartl +47 more
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Hippo signaling activates hedgehog signaling by Taz-driven Gli3 processing
Cell Regeneration, 2023 The overlapping roles of Hippo and Hedgehog signaling in biological functions and diseases prompt us to investigate their potential interactions. Activation of Hippo signaling enhances the transcriptional output of Hedgehog signaling, and the role of ...
Chao Tang +7 more
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Sonic hedgehog specifies flight feather positional information in avian wings [PDF]
, 2023 Classical tissue recombination experiments performed in the chick embryo provide evidence that signals operating during early limb development specify the position and identity of feathers.
McQueen, Caitlin +5 more
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Development and validation of a hedgehog heparin-binding assay for high-throughput screening
MethodsX, 2021 Sonic hedgehog (Shh) is a morphogenic protein with critical roles in embryogenesis and the development of some cancers. Hence, identifying inhibitors of the Shh pathway is of great therapeutic value.
David R. Lamson +4 more
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Tobacco Induced Diseases, 2019 Introduction Many studies have shown that COPD is associated with apoptosis of bronchial or alveolar epithelial cells. Alveolar type II epithelial cells (AECII) play an important role in the pathogenetic process.
Jinhua Li +3 more
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Nature Communications, 2021 Dispatched (Disp) RND transporter, activated by Furin-mediated proteolytic cleavage, mediates the release of the lipid-modified Hedgehog (Hh) ligands. Here, the authors report structures of human Disp1 (hDisp1) before and after cleavage, and in complex ...
Wanqiu Li +9 more
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