Meningioma cells express primary cilia but do not transduce ciliary Hedgehog signals
Acta Neuropathologica Communications, 2020 Meningiomas are the most common primary intracranial tumors, but treatment options for meningioma patients are limited due to incomplete understanding of tumor biology.
Sarah Findakly +5 more
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Maintenance of Taste Organs Is Strictly Dependent on Epithelial Hedgehog/GLI Signaling. [PDF]
PLoS Genetics, 2016 For homeostasis, lingual taste papilla organs require regulation of epithelial cell survival and renewal, with sustained innervation and stromal interactions.
Alexandre N Ermilov +7 more
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More Surprises in the Hedgehog Signaling Pathway [PDF]
Cell, 2000 The author regrets that, owing to severe space limitations, key pieces of work have been cited using reviews rather than the original articles.
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Hedgehog Signaling as a Therapeutic Target for Airway Remodeling and Inflammation in Allergic Asthma
Cells, 2022 Genome-wide association studies (GWAS) have shown that variants of patched homolog 1 (PTCH1) are associated with lung function abnormalities in the general population.
Anthony Tam +13 more
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Canonical Hedgehog Pathway and Noncanonical GLI Transcription Factor Activation in Cancer
, 2022 The Hedgehog signaling pathway is one of the fundamental pathways required for development and regulation of postnatal regeneration in a variety of tissues.
Chamey Suchors +3 more
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Context-dependent ciliary regulation of hedgehog pathway repression in tissue morphogenesis.
PLoS Genetics, 2023 A fundamental problem in tissue morphogenesis is identifying how subcellular signaling regulates mesoscale organization of tissues. The primary cilium is a paradigmatic organelle for compartmentalized subcellular signaling.
Sun-Hee Hwang +4 more
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The Utility of Hedgehog Signaling Pathway Inhibition for Cancer [PDF]
The Oncologist, 2012 Abstract The Hedgehog (Hh) signaling pathway has been implicated in tumor initiation and metastasis across different malignancies. Major mechanisms by which the Hh pathway is aberrantly activated can be attributed to mutations of members of Hh pathway or excessive/inappropriate expression of Hh pathway ligands.
Solmaz, Sahebjam +2 more
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Hedgehog Signaling and Embryonic Craniofacial Disorders
Journal of Developmental Biology, 2019 Since its initial discovery in a Drosophila mutagenesis screen, the Hedgehog pathway has been revealed to be instrumental in the proper development of the vertebrate face. Vertebrates possess three hedgehog paralogs: Sonic hedgehog (Shh), Indian hedgehog
John Abramyan
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Quantitative Immunoblotting of Endogenous Hedgehog Pathway Components
, 2015 Quantitative analysis and modeling of signaling pathway components can reveal important information about the dynamics of that system, including the relative stoichiometries and affinities between the individual signaling components, as well as rate ...
Robbins, David J +3 more
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Loss of FTO Antagonises Wnt Signaling and Leads to Developmental Defects Associated with Ciliopathies [PDF]
, 2014 Common intronic variants in the Human fat mass and obesity-associated gene (FTO) are found to be associated with an increased risk of obesity. Overexpression of FTO correlates with increased food intake and obesity, whilst loss-of-function results in ...
Rosa Maria Roccasecca (519728) +40 more
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