Results 181 to 190 of about 92,914 (298)

Cortical‐Hypothalamic Assembloids Uncover the Cortical Regulation of Hypothalamic Responses to Fatty Acid

Cell Proliferation, EarlyView.
By assembling cortical‐hypothalamic circuits, we show that cortical input protects hypothalamic neurons from fatty acid‐induced damage, which activates PGC1α to boost mitochondrial function. This reveals a cortico‐hypothalamic axis that defends against metabolic stress.
Mengdan Tao, Xiaowen Du, Qi Chen, Wenxin Mu, Shuning Lou, Xu Zhang, Min Xu, Jiting Li, Yuxuan Guo, Wanying Zhu, Yan Liu   +10 more
wiley   +1 more source

Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape

The FEBS Journal, EarlyView.
The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto, Naike Casagrande, Emanuele Di Siena, Greta Carobolante, Lucrezia Camicia, Giorgia Schinello, Samanta Muzzin, Enrica Timis, Paola Spessotto, Maurizio Mongiat   +9 more
wiley   +1 more source

NSUN4-mediated m5C RNA methylation protects retinal cells against excitotoxic injury via the SHH signaling pathway. [PDF]

PLoS One
Li Y, Li D, Geng C, Wei R, Duan Y.
europepmc   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

RING1B-BMI1 catalyzed dynamic H2AK119ub1 modification in response to sonic hedgehog signalling during pancreatic differentiation of human embryonic stem cells. [PDF]

Sci Rep
Dumasia NP, Pethe PS.
europepmc   +1 more source

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source

Hedgehog signaling in humans: the HH_Signal pathway_db knowledge base. [PDF]

Vavilovskii Zhurnal Genet Selektsii
Bukharina TA, Bondarenko AM, Furman DP.
europepmc   +1 more source

Traumatic Occlusion Exacerbates Bone Resorption by Modifying Gene Expression in the Bone Tissue of Ligature‐Induced Periodontitis in Mice

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim To clarify the molecular mechanisms of occlusal trauma in bone loss through periodontal tissue transcriptome analysis in mice with periodontitis and traumatic occlusion. Materials and Methods Ligature‐induced periodontitis (Li) and composite resin‐induced traumatic occlusion (Tra) mouse models were established (control [Co], Li, Tra and ...
Yosuke Tsuchiya, Yujin Ohsugi, Tomomitsu Hirota, Yohei Hayashi, Peiya Lin, Yuta Tsukahara, Takanori Iwata, Sayaka Katagiri   +7 more
wiley   +1 more source

Shikonin inhibits multiple tumor malignant phenotypes and is associated with Hedgehog pathway downregulation in lung adenocarcinoma. [PDF]

Sci Rep
Wang HG, Lu MX, Sheng ML, Lou YB, Xiao YC, Guo A, Yu ZH.   +6 more
europepmc   +1 more source

Does any fish scale of a fish have the same number of marks? A case study for two Mugilidae species

Journal of Fish Biology, EarlyView.
Abstract This study evaluates the difference in growth marks in scales from nine body areas of two Mugilidae species from the Gulf of Mexico: Mugil curema and Mugil cephalus. It addresses whether the different body areas show more (or fewer) marks, and which area(s) would be more useful in fish biology studies relying on mark analysis.
Ebenecer Guerra, Arturo Bell Enríquez‐García, Víctor H. Cruz‐Escalona, Eloísa Pacheco‐Almanzar, Sergio Álvarez‐Hernández, Emigdio Marín‐Enríquez, Ana Laura Ibáñez   +6 more
wiley   +1 more source