Results 231 to 240 of about 92,914 (298)

RXR Gamma Enables Oligodendrocyte Differentiation by Suppressing Sonic Hedgehog Signaling

Glia, Volume 74, Issue 6, June 2026.
Using pharmacogenetic approaches, Baldassarro et al. demonstrate that RXRγ suppresses the SHH signaling pathway in OPCs to ensure their efficient differentiation following T3 stimulation. Accordingly, Rxrg−/− OPCs displayed compromised differentiation which was normalized by the pharmacological inhibition of the hyperactive SHH pathway.
Vito Antonio Baldassarro, Quentin Brassart, Valérie Fraulob, Laura Calzà, Wojciech Krezel   +4 more
wiley   +1 more source

STK38-mediated feedback loop regulation of the hedgehog pathway governing tumor heterogeneity in renal papillary carcinoma. [PDF]

Cell Death Dis
Du Y, Sui X, Zheng Z, Zhang Z, Liu B, Bai Y, Zhao Y, Wu Q, Wu H, Zhong M, Li L, Sun H, Shao C.   +12 more
europepmc   +1 more source

Whole Genome Sequence Analysis of Weight Loss in 16 972 Participants With COPD Reveals Novel Risk Loci in DRAIC and RFX3

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Chronic obstructive pulmonary disease (COPD) is associated with musculoskeletal comorbidities, including cachexia. Weight loss (WL) is the major criterion for cachexia and increases risk for mortality in COPD. Risk factors for WL in COPD are incompletely understood.
Joe W. Chiles III, Alison Rocco, Vinodh Srinivasasainagendra, Harry B. Rossiter, Richard Casaburi, Anna Thalacker‐Mercer, J. Michael Wells, Emily S. Wan, Edwin K. Silverman, Michael H. Cho, Craig P. Hersh, Bruce M. Psaty, Sina A. Gharib, Yan Gao, George T. O'Connor, Leslie A. Lange, Stephen S. Rich, Ani W. Manichaikul, R. Graham Barr, Victor E. Ortega, Deborah A. Meyers, Albert V. Smith, Hemant K. Tiwari, Merry‐Lynn N. McDonald   +23 more
wiley   +1 more source

Cancer Stem Cells in Human Gastrointestinal and Hepatic Cancers. [PDF]

MedComm (2020)
Bu J, Cui M, Zhang Y, Lu Y, Zhu X, Peng F, Zhang H.   +6 more
europepmc   +1 more source

Deletion of a Pax1 Sex‐Associated Genomic Region Associated With Adolescent Idiopathic Scoliosis Leads to Disc Degeneration, Instability, and Vertebral Rotation in Mice

JOR SPINE, Volume 9, Issue 2, June 2026.
Overview of the effects of Pax1‐SAR deletion on gene expression, IVD degeneration, and resultant scoliotic‐like curvature between sexes. Proposed mechanism of sex‐dependent changes in gene expression in females (right) and males (left), resulting in sex‐dependent disc degeneration and scoliotic phenotypes.
Edward C. Moody, Emma M. Wade, Shuji Mizumoto, Jeremy McCallum‐Loudeac, Megan J. Wilson   +4 more
wiley   +1 more source

Analyzing Hedgehog pathway-related genes: insights into breast cancer tumor microenvironment and prognostic implications. [PDF]

Front Immunol
Wang Z, Wang H.
europepmc   +1 more source

Redox Regulation and Oxidative Stress in Health and Disease: Mechanisms and Therapeutic Targeting

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
Reactive species serve crucial roles which are tightly regulated in both physiological as well as disease states. At physiological levels, these species are integral to redox signaling, while uncontrolled redox promotes disease pathology. This review examines the dysregulation of these processes.
Mohammad Hossein Azadi, Azadeh Niknejad, Elaheh Amini   +2 more
wiley   +1 more source

Dissection of Gαs and Hedgehog Signaling Cross-talk Reveals Therapeutic Opportunities to Target Hedgehog-Dependent Tumors. [PDF]

Cancer Res
Krantz S, Bell BA, Lund K, Salinas Parra N, Ng Y, De Oliveira Rosa N, Mukhopadhyay S, St Croix B, Sarin KY, Weigert R, Raimondi F, Iglesias-Bartolome R.   +11 more
europepmc   +1 more source

Colorectal Precancerous Lesions: Molecular Mechanisms, Research Tools, and Natural Product‐Based Clinical Translation

MedComm – Oncology, Volume 5, Issue 2, June 2026.
This article systematically elucidates the molecular mechanisms of colorectal precancerous lesions, introduces cutting‐edge research tools like multi‐omics and organoids, and highlights the potential and prospects of natural products such as berberine, resveratrol, and curcumin in preventing and intervening in colorectal carcinogenesis by modulating ...
Shunji Liu, Chujuan Cui, Lingdong Kong, Qiang Xu, Haibo Cheng, Lisha Zhou, Yang Sun   +6 more
wiley   +1 more source

CSNK1D inhibition suppresses head and neck squamous cell carcinoma progression through SHH and PTCH1 pathway. [PDF]

Cell Death Dis
Yang L, Li X, Zhu Y, Zhang Y, Liu Z, Lin C, Jiang C, Su YX, Ji T, Wang Y, Gao J, Ye J.   +11 more
europepmc   +1 more source