Results 231 to 240 of about 55,434 (254)
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Purifying the Hedgehog Protein and its Variants
2007The purification of recombinant versions of the N-terminal signaling fragment of Sonic hedgehog (ShhN) from E. coli, Hi-5 insect cells, yeast, and mammalian cell sources reveals diverse post-translational modifications that affect the potency of the purified protein. Modifications to the N-terminal cysteine with fatty acyl groups results in significant
Darren P, Baker +2 more
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Age-dependent effects of hedgehog protein on chondrocytes
The Journal of Bone and Joint Surgery. British volume, 1999Bone morphogenetic protein (BMP) has a crucial role in osteochondrogenesis of bone formation as well as in the repair of fractures. The interaction between hedgehog protein and BMPs is inferred from recent molecular studies. Hedgehog genes encode secreted proteins which mediate patterning and growth during skeletal development.
M, Iwasaki, A, Jikko, A X, Le
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Translating Hedgehog in Cancer: Controlling Protein Synthesis
Trends in Molecular Medicine, 2016Developmental Hedgehog (Hh) signaling is found deregulated in a broad spectrum of human malignancies and, thus, is an attractive target for cancer therapy. Currently available Hh inhibitors have shown the rapid occurrence of drug resistance, due to altered signaling in collateral pathways.
D'AMICO, Davide, CANETTIERI, Gianluca
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Annals of the New York Academy of Sciences, 2006
Abstract: Hedgehog (HH) is a secreted protein named for the bristle phenotype observed in Drosophila embryos that lack the corresponding gene. Three homologs have been characterized in vertebrates, all which have critical roles in the development of multiple organ systems.
James A, Waschek +3 more
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Abstract: Hedgehog (HH) is a secreted protein named for the bristle phenotype observed in Drosophila embryos that lack the corresponding gene. Three homologs have been characterized in vertebrates, all which have critical roles in the development of multiple organ systems.
James A, Waschek +3 more
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The cytoskeletal protein zyxin interacts with the Hedgehog receptor patched
Russian Journal of Bioorganic Chemistry, 2015Earlier, we demonstrated Zyxin influence upon Hedgehog (Hh)-signaling pathway during early patterning of the central neural system (CNS) anlage of the Xenopus laevis embryo. Now we show that Zyxin can physically interact with the transmembrane receptor of Hh, Patched2 (Ptc2).
N U, Martynova +3 more
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Targeting of proteins to membranes through hedgehog auto-processing
Nature Biotechnology, 2003Hedgehog proteins use an auto-processing strategy to generate cholesterol-conjugated peptide products that act as extracellular ligands in a number of developmental signaling pathways. We describe an approach that takes advantage of the hedgehog auto-processing reaction to carry out intracellular modification of heterologous proteins, resulting in ...
Sylvie, Vincent +3 more
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Hedgehog and Protein Kinase C Signaling
2011Hedgehog (HH) and protein kinase C (PKC) signaling pathways are critically involved in embryonic development, stem cells, and cancer cells. Recent evidence has shown the regulation of these phenotypes by the crosstalk between the HH and PKC pathways. Among the PKC family, PKCα and PKCδ are important isoforms involved in HH pathway regulation.
Jing Li, B. Mark Evers
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Protein Kinase A Activity and Hedgehog Signaling Pathway
2012Protein kinase A (PKA) is a well-known kinase that plays fundamental roles in a variety of biological processes. In Hedgehog-responsive cells, PKA plays key roles in proliferation and fate specification by modulating the transduction of Hedgehog signaling. In the absence of Hedgehog, a basal level of PKA activity represses the transcription of Hedgehog
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Regulatory mechanisms governing GLI proteins in hedgehog signaling
Anatomical Science InternationalThe Hedgehog (Hh) signaling pathway is critical for regulating cell growth, survival, fate determination, and the overall patterning of both vertebrate and invertebrate body plans. Aberrations in Hh signaling are associated with congenital abnormalities and tumorigenesis. In vertebrates, Hh signaling depends uniquely on primary cilia, microtubule-based
Saishu Yoshida, Kiyotsugu Yoshida
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