Results 221 to 230 of about 55,658 (256)

Sonic Hedgehog Protein

CNS Drugs, 1998
Sonic hedgehog is a member of a newly discovered family of molecules that are active during development in vertebrates. Sonic hedgehog induces development of key CNS neuronal cell types, including the dopaminergic neurons that are destroyed in Parkinson's disease.
K, Pang, T D, Ingolia
openaire   +2 more sources

Serum proteins in young hedgehogs

Journal of Zoology, 1970
Four serum protein components are present at birth: α‐, β‐ and γ‐globulins and albumin.The preferential transfer of γ rather than β‐globulin, which occurs both prenatally and postnatally in this species, is reflected in the initial amounts of these proteins present at birth and in the relatively rapid increase in the concentration of γ‐globulin which ...
Morris, B., Rudge, G.
openaire   +1 more source

Purifying the Hedgehog Protein and its Variants

2007
The purification of recombinant versions of the N-terminal signaling fragment of Sonic hedgehog (ShhN) from E. coli, Hi-5 insect cells, yeast, and mammalian cell sources reveals diverse post-translational modifications that affect the potency of the purified protein. Modifications to the N-terminal cysteine with fatty acyl groups results in significant
Darren P, Baker, Frederick R, Taylor, R Blake, Pepinsky   +2 more
openaire   +2 more sources

Age-dependent effects of hedgehog protein on chondrocytes

The Journal of Bone and Joint Surgery. British volume, 1999
Bone morphogenetic protein (BMP) has a crucial role in osteochondrogenesis of bone formation as well as in the repair of fractures. The interaction between hedgehog protein and BMPs is inferred from recent molecular studies. Hedgehog genes encode secreted proteins which mediate patterning and growth during skeletal development.
M, Iwasaki, A, Jikko, A X, Le
openaire   +2 more sources

Translating Hedgehog in Cancer: Controlling Protein Synthesis

Trends in Molecular Medicine, 2016
Developmental Hedgehog (Hh) signaling is found deregulated in a broad spectrum of human malignancies and, thus, is an attractive target for cancer therapy. Currently available Hh inhibitors have shown the rapid occurrence of drug resistance, due to altered signaling in collateral pathways.
D'AMICO, Davide, CANETTIERI, Gianluca
openaire   +4 more sources

Protein Kinase A Activity and Hedgehog Signaling Pathway

2012
Protein kinase A (PKA) is a well-known kinase that plays fundamental roles in a variety of biological processes. In Hedgehog-responsive cells, PKA plays key roles in proliferation and fate specification by modulating the transduction of Hedgehog signaling. In the absence of Hedgehog, a basal level of PKA activity represses the transcription of Hedgehog
openaire   +2 more sources

Gi proteins mediate activation of the canonical hedgehog pathway in the myocardium

American Journal of Physiology - Heart and Circulatory Physiology, 2014
Walter Koch, Erhe Gao, Natalia Riobo-Del Galdo   +2 more
exaly  

Hedgehog Proteins Stimulate Chondrogenic Cell Differentiation and Cartilage Formation

Journal of Bone and Mineral Research, 2000
Maurizio Pacifici, Tomonao Aikawa, Takashi Nakamura   +2 more
exaly  

Gli-type zinc finger proteins as bipotential transducers of Hedgehog signaling

Differentiation, 2002
Tomáš Pieler
exaly  

Review for "Palmitoylation of Hedgehog proteins by Hedgehog acyltransferase: roles in signalling and disease"

2021
openaire   +1 more source