Results 221 to 230 of about 55,434 (254)
Crystal Structure of a Hedgehog Autoprocessing Domain: Homology between Hedgehog and Self-Splicing Proteins [PDF]
Cell, 1997 The approximately 25 kDa carboxy-terminal domain of Drosophila Hedgehog protein (Hh-C) possesses an autoprocessing activity that results in an intramolecular cleavage of full-length Hedgehog protein and covalent attachment of a cholesterol moiety to the newly generated amino-terminal fragment.
Traci M Tanaka Hall +2 more
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Serum Proteins in the Hedgehog
Acta Physiologica Scandinavica, 1967AbstractHedgehog serum proteins were studied by physical, chemical and immunological methods. The paper electrophoretic and immunoelectrophoretic patterns did not differ greatly from those of human serum. In paper electrophoresis two beta‐bands were found, the beta2‐band being the most conspicuous. In the immunoelectrophoretic pattern, the form of the “
B, Larsen, O, Tönder
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Autoproteolysis in hedgehog protein biogenesis
Science, 1994Extracellular signaling proteins encoded by the hedgehog (hh) multigene family are responsible for the patterning of a variety of embryonic structures in vertebrates and invertebrates. The Drosophila hh gene has now been shown to generate two predominant protein species that are derived by an internal autoproteolytic cleavage of a larger precursor ...
J J, Lee +5 more
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Gli proteins and Hedgehog signaling: development and cancer
Trends in Genetics, 1999 A surprising number of apparently unrelated human diseases, including familial and sporadic cancers and a number of syndromes and malformations, seem to be associated with abnormal function of the Hedgehog (Hh) signaling pathway. Zinc-finger transcription factors of the Gli family play critical roles in the mediation and interpretation of Hh signals ...
Ariel Ruiz I Altaba
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Protein modifications in Hedgehog signaling
BioEssays, 2021AbstractThe complexity of the Hedgehog (Hh) signaling cascade has increased over the course of evolution; however, it does not suffice to accommodate the dynamic yet robust requirements of differential Hh signaling activity needed for embryonic development and adult homeostatic maintenance.
Min Liu +3 more
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Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein
Nature, 1999The Hedgehog signalling pathway is essential for the development of diverse tissues during embryogenesis. Signalling is activated by binding of Hedgehog protein to the multipass membrane protein Patched (Ptc). We have now identified a novel component in the vertebrate signalling pathway, which we name Hip (for Hedgehog-interacting protein) because of ...
P T, Chuang, A P, McMahon
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The mammalian Hedgehog pathway is modulated by ANP32 proteins
Biochemical and Biophysical Research Communications, 2021Medulloblastoma (MB) is the most common malignant brain tumor in children. Transcriptional profiling has so far delineated four major MB subgroups of which one is driven by uncontrolled Hedgehog (Hh) signaling (SHH-MB). This pathway is amenable to drug targeting, yet clinically approved compounds exclusively target the transmembrane component ...
Anna Hupfer +3 more
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Regulation ofnetrin-1aExpression by Hedgehog Proteins
Molecular and Cellular Neuroscience, 1998Netrins, a family of growth cone guidance molecules, are expressed both in the ventral neural tube and in subsets of mesodermal cells. In an effort to better understand the regulation of netrins, we examined the expression of netrin-1a in mutant cyclops, no tail, and floating head zebrafish embryos, in which axial midline structures are perturbed ...
Lauderdale, J. +6 more
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CNS Drugs, 1998
Sonic hedgehog is a member of a newly discovered family of molecules that are active during development in vertebrates. Sonic hedgehog induces development of key CNS neuronal cell types, including the dopaminergic neurons that are destroyed in Parkinson's disease.
K, Pang, T D, Ingolia
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Sonic hedgehog is a member of a newly discovered family of molecules that are active during development in vertebrates. Sonic hedgehog induces development of key CNS neuronal cell types, including the dopaminergic neurons that are destroyed in Parkinson's disease.
K, Pang, T D, Ingolia
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Serum proteins in young hedgehogs
Journal of Zoology, 1970Four serum protein components are present at birth: α‐, β‐ and γ‐globulins and albumin.The preferential transfer of γ rather than β‐globulin, which occurs both prenatally and postnatally in this species, is reflected in the initial amounts of these proteins present at birth and in the relatively rapid increase in the concentration of γ‐globulin which ...
Morris, B., Rudge, G.
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