Results 121 to 130 of about 956,727 (289)

Differential sensitivity to SHH signaling and neural crest‐mediated Gas1 expression regulate jaw size during development and evolution

Developmental Dynamics, EarlyView.
Abstract Background Developmental control of jaw size is crucial to prevent birth defects and facilitate evolutionary adaptation. We have shown that jaw size is established by neural crest mesenchyme (NCM), which are progenitor cells that migrate into the mandibular primordia and produce the jaws.
Zuzana Vavrušová, Daniel B. Chu, An Nguyen, Yeniko Ta, Jennifer L. Fish, Richard A. Schneider   +5 more
wiley   +1 more source

Roughing Up Smoothened: Chemical Modulators of Hedgehog Signaling [PDF]

, 2013
Small-molecule antagonists of Hedgehog-pathway signaling, such as cyclopamine, have been known for some time. Now, small-molecule agonists of the Hedgehog pathway have also been identified.
King, Randall
core   +2 more sources

Membrane lipid metabolism as a regulatory frontier in neural crest biology: Roles for sphingolipids, cholesterol, and lipid rafts

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are multipotent, migratory stem‐like cells essential for vertebrate development that contribute broadly to many tissues including the craniofacial skeleton, peripheral nervous system, and pigment‐producing cells. Their development progresses through phases of induction, specification, delamination, migration, and ...
Allison E. Mancini, Mallorie P. Jenne, Michael L. Piacentino   +2 more
wiley   +1 more source

Motile cilia of human airway epithelia contain hedgehog signaling components that mediate noncanonical hedgehog signaling

, 2018
Significance Previous studies localized the hedgehog (HH) signaling system to primary cilia. We discovered that motile cilia on airway epithelia also contain HH signaling proteins, indicating that like primary cilia, these motile cilia have an ...
Sarah E. Ernst, Leah R. Reznikov, Michael J. Welsh, Mahmoud H. Abou Alaiwa, Philip H. Karp, Ping Tan, Lynda S. Ostedgaard, Lin Lu, Xiao Xiao Tang, Alok S. Shah, Shaf Keshavjee, Ian M. Thornell, Suifang Mao, Thomas O. Moninger   +13 more
core   +1 more source

The matrilineal Turn: Wiradjuri matrilineal leadership, colonial disruption, and the work of cultural return

Feminist Anthropology, EarlyView.
Abstract This article advances three claims regarding the matrilineal organization of Wiradjuri society in central New South Wales. Drawing on the late nineteenth and early twentieth century ethnographic record, it demonstrates that Wiradjuri descent, totem, moiety identity, and ceremonial authority were and are matrilineally organized, despite ...
Jessa Rogers
wiley   +1 more source

A Hedgehog–Foxf axis coordinates dental follicle-derived alveolar bone formation

Nature Communications
The alveolar bone is a specialized mineralized structure supporting the lifelong functionality of the tooth in mastication. The alveolar bone develops from the dental follicle (DF) during tooth root formation due to deliberate epithelial–mesenchymal ...
Mizuki Nagata, Gaurav T. Gadhvi, Taishi Komori, Yuki Arai, Chiaki Tsutsumi-Arai, Angel Ka Yan Chu, Seth N. Nye, Yuntao Yang, Shion Orikasa, Akira Takahashi, Peter Carlsson, W. Jim Zheng, Joshua D. Welch, Noriaki Ono, Wanida Ono   +14 more
doaj   +1 more source

Focus Issue: Fine-Tuning Hedgehog Signaling in Development and Disease

, 2011
The Hedgehog signaling cascade is regulated by a complex and diverse set of mechanisms.
Annalisa M. VanHook
core   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Hedgehog signaling in human hepatocellular carcinoma

, 2005
Hepatocellular carcinoma (HCC) is the fourth most common malignancy and one of the leading causes of death world wide. Signaling pathways important for tumor initiation and progression in HCC are poorly understood.
Ho, C, Patil, MA, Fan, ST, Coral Ho, Sheung-Tat Fan, Cheung, ST, Mohini A. Patil, Xin Chen, Chen, X, Ji Zhang, Siu-Tim Cheung, Zhang, J   +11 more
core   +1 more source

Avoiding “Failure of Foresight” or Tunnel Vision Requires a Multi‐Paradigmatic Strategic Decision‐Making Approach

Strategic Change, EarlyView.
ABSTRACT This paper considers the tensions between different organizational strategic decision‐making approaches at various levels of uncertainty. Of particular focus are the mechanisms for defaulting to lower uncertainty, from the Cynefin framework's unordered chaotic and complex domains to the more ordered complicated and obvious domains.
Richard J. Logan, Robert Y. Cavana, Bronwyn E. Howell, Ian Yeoman   +3 more
wiley   +1 more source