Results 101 to 110 of about 956,727 (289)
Gli2, hedgehog and TCR signalling
Oncotarget, 2015 A structurally and functionally diverse T-cell repertoire is essential for each of the key roles of the adaptive immune system: elimination of foreign pathogens, provision of immunological memory and the maintenance of tolerance to self. T-cells develop in the thymus and then migrate to the periphery where they undergo activation and functional ...
Furmanski, Anna L., Crompton, Tessa
openaire +3 more sources
The “costly son” hypothesis: Sons exacerbate obstetrical dilemmas in humans and other mammals
The Anatomical Record, EarlyView.Abstract Human childbirth has often been considered uniquely difficult among mammals, yet recent evidence suggests that obstructed labor and fetopelvic disproportion are widespread across placental mammals. Here, we propose the “costly son” hypothesis: because male offspring are typically larger at birth, they impose greater obstetric risk on mothers ...
Nicole D. S. Grunstra +1 more
wiley +1 more source
Mechanisms and therapeutic potential of the hedgehog signaling pathway in cancer
Cell Death DiscoveryA sort of major malignant disease, cancer can compromise human health wherever. Some mechanisms of the occurrence and evolution of cancer still seem elusive even now. Consequently, the therapeutic strategies for cancer must continually evolve.
Ge Cong +4 more
doaj +1 more source
Hedgehog Signaling in Endochondral Ossification [PDF]
Journal of Developmental Biology, 2016 Hedgehog (Hh) signaling plays crucial roles in the patterning and morphogenesis of various organs within the bodies of vertebrates and insects. Endochondral ossification is one of the notable developmental events in which Hh signaling acts as a master regulator.
openaire +3 more sources
Follicle Stimulating Hormone in Cattle Breeding: Fundamentals, Innovations, and Scope
Animal Research and One Health, EarlyView.FSH is crucial in cattle reproduction, with exogenous administration enhancing breeding and embryo production. Recombinant FSH offers advantages over pituitary‐extracted variants, including fewer injections, reduced stress, and safer production. These innovations improve breeding efficiency, optimize reproductive outcomes, and contribute to sustainable
Muhammad Shahzad +7 more
wiley +1 more source
TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia
CNS Neuroscience &Therapeutics, EarlyView., 2023 Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi +19 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum +5 more
wiley +1 more source
Hedgehog Signaling: Iguana Debuts as a Nuclear Gatekeeper
, 2004 The intracellular pathway that controls the cytoplasmic versus nuclear distribution of Gli transcriptional regulators in response to Hedgehog signaling remains poorly understood.
Vokes, Steven A., McMahon, Andrew P.
core +1 more source
Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges
BMEMat, EarlyView.This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma +8 more
wiley +1 more source