Results 151 to 160 of about 956,727 (289)

Molecular profiling of pediatric medulloblastoma in Kazakhstan: Genomic alterations, subgroup distribution, and survival

Brain Pathology, EarlyView.
A practical formalin‐fixed, paraffin‐embedded (FFPE)‐based molecular workflow integrating pathology, immunohistochemistry, and genomic profiling provides clinically meaningful subgroup classification of pediatric medulloblastoma and expands molecular evidence from an underrepresented Central Asian population. Abstract Medulloblastoma is the most common
Aidos Bolatov, Askhat Zhakupov, Aizhan Abdikadirova, Malika Sapargaliyeva, Bakytkali Ibraimov, Zhanat Zhalimbetova, Gabit Ólenbay, Berik Zhetpisbayev, Xingzhi Xu, Mirgul Bayanova   +9 more
wiley   +1 more source

[Retracted] Effects and mechanisms of blocking the hedgehog signaling pathway in human gastric cancer cells. [PDF]

Oncol Lett
Gu H, Li X, Zhou C, Wen Y, Shen Y, Zhou L, Li J.   +6 more
europepmc   +1 more source

Musashi‐1 Drives Radioresistance and Stemness in Head and Neck Squamous Cell Carcinoma via a Radioresistant FaDu Model

Cancer Science, EarlyView.
Fractionated irradiation generated radioresistant F‐IRR cells with enhanced CSC properties despite slower proliferation. MSI1 was strongly upregulated and functionally promoted stemness, tumorigenicity, and radiation resistance. JNK signaling acted upstream of MSI1, while JNK inhibition suppressed these malignant traits, identifying the JNK–MSI1 axis ...
Na‐Eun Kang, Chan‐Woong Jung, Yun‐Ju Kim, Sung‐Gil Chi, Jeong‐Yub Kim, Myung‐Jin Park   +5 more
wiley   +1 more source

Ldha Regulates Osteosarcoma Lung Metastasis through Hedgehog Signaling. [PDF]

Cancer Res Commun
Maki R, Komura S, Nagano A, Niwa A, Tomita H, Imai Y, Akiyama H.   +6 more
europepmc   +1 more source

Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb.

, 1996
Hedgehog genes have been implicated in inductive signaling during development in a variety of organisms. A key element of the hedgehog signaling system is encoded by the gene patched.
MARIGO, Valeria, TABIN C. J., GOODRICH L. V., SCOTT M. P., JOHNSON R. L.   +4 more
core  

Anti-aging effect of Hedgehog signaling. [PDF]

Exp Mol Med
Kim JH, Hwang JY, Jun JH, Diehl AM.
europepmc   +1 more source

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source

Transdifferentiation of endothelial progenitor cells into rhabdomyosarcoma defined by hedgehog signaling competence. [PDF]

Cell Rep
Gadek KE, Drummond CJ, Jin H, Garcia MR, Mathew ED, Adkins GE, Langdon CG, Evans M, Searcy MB, Schreiner P, Maguire M, Rehg JE, Ogden SK, Hatley ME.   +13 more
europepmc   +1 more source

Acyl guanidine derivatives modulating the hedgehog protein signaling pathway

, 2011
The present invention relates to acyl guanidine derivatives modulating the hedgehog protein signaling pathway to be used as drugs, in particular for treating diseases involving a tissue dysfunction associated with a deregulation of the hedgehog protein ...
Traiffort E, Roudaut H, Schoenfelder A, Ruat M, MANETTI, FABRIZIO, Mann A, TADDEI, MAURIZIO, Fraure H, Solinas A.   +8 more
core  

The sorting nexin Snx21 promotes flotillin‐mediated endocytosis

The FEBS Journal, EarlyView.
In this study, we describe a novel function of the previously uncharacterized Snx21 protein as a specific positive regulator of flotillin‐mediated endocytic trafficking. Snx21 is recruited to endosomal membranes via binding to PI(3)P, and it colocalizes with flotillins on the surface of late endosomes.
Tamás Maruzs, Enikő Lakatos, Dalma Feil‐Börcsök, Gábor Juhász, Regina Mező, Asha Kiran Maddali, András Blastyák, Aladár Pettkó‐Szandtner, Hajnalka Laczkó‐Dobos, Gábor Juhász   +9 more
wiley   +1 more source