Results 161 to 170 of about 58,953 (264)

The sorting nexin Snx21 promotes flotillin‐mediated endocytosis

The FEBS Journal, EarlyView.
In this study, we describe a novel function of the previously uncharacterized Snx21 protein as a specific positive regulator of flotillin‐mediated endocytic trafficking. Snx21 is recruited to endosomal membranes via binding to PI(3)P, and it colocalizes with flotillins on the surface of late endosomes.
Tamás Maruzs, Enikő Lakatos, Dalma Feil‐Börcsök, Gábor Juhász, Regina Mező, Asha Kiran Maddali, András Blastyák, Aladár Pettkó‐Szandtner, Hajnalka Laczkó‐Dobos, Gábor Juhász   +9 more
wiley   +1 more source

[Retracted] Hsp90 inhibitor 17‑AAG inhibits stem cell‑like properties and chemoresistance in osteosarcoma cells via the Hedgehog signaling pathway. [PDF]

Oncol Rep
Shu X, Liu H, Zhen R, Jie Y, Chen L, Qi H, Wang C, Wang R, Chen D, Ran Y.   +9 more
europepmc   +1 more source

Stable Isotope–Enabled Particle Drift Models Predict Where High‐Resolution Isotope Analyses Can Discriminate Among Larval Trajectories in Atlantic Mackerel

Fisheries Oceanography, EarlyView.
ABSTRACT Marine fish commonly move across distinct habitats throughout their lifetimes, particularly during larval stages, when they are particularly difficult to track. Such transitions are necessary as environmental demands and predation pressures change dramatically with increases in body size.
Yuan Tian Chou, Robert Marsh, Ewan Hunter, Clive N. Trueman   +3 more
wiley   +1 more source

A characterization of axolotl digit regeneration: conserved mechanisms, divergent patterning, and a critical role for hedgehog signaling. [PDF]

NPJ Regen Med
Griffiths JR, Miller M, Duerr TJ, Owen AE, Monaghan JR.   +4 more
europepmc   +1 more source

The long and short of hedgehog signaling

Cell, 1995
Johnson, Randy L, Tabin, Cliff
openaire   +2 more sources

The Role of Neuropeptide Y in Dental Pulp: Balancing Neurogenic Inflammation and Pain Modulation

International Endodontic Journal, EarlyView.
ABSTRACT Background Dental pulp is a densely innervated, low‐compliance tissue in which neurogenic inflammation can rapidly escalate into oedema, raised intrapulpal pressure, microvascular compromise, and pain. While Substance P (SP) and Calcitonin gene‐related peptide (CGRP) are well‐established drivers of pulp vasodilation, the Neuroopeptide Y (NPY ...
Javier Caviedes‐Bucheli, Esteban Ulate, Hugo‐Roberto Munoz, Nestor Ríos‐Osorio   +3 more
wiley   +1 more source

Activated Hedgehog signaling in keratocytes leads to stromal stiffness and impairs corneal regeneration. [PDF]

NPJ Regen Med
Yu Q, Li P, Du Z, Che M, Zhao H, Li B, Zhao P, Li J.   +7 more
europepmc   +1 more source

The tympanic covering layer contributes to basilar membrane elasticity potentially influencing human frequency resolution and speech perception

Journal of Anatomy, EarlyView.
In this study we show for the first time that the human basilar membrane contains elastin produced by the so‐called tympanic covering layer. It is believed to play an important functional role in human cochlear tuning, particularly low frequencies linked to our remarkable speech and music perception.
Wei Liu, Claudia Steinacher, Alexander Glueckert, Rudolf Glueckert, Hao Li, Karin Staxäng, Anneliese Schrott‐Fischer, Hanif M. Ladak, Sumit Agrawal, Helge Rask‐Andersen   +9 more
wiley   +1 more source

Transcriptomic profiling reveals the role of Hedgehog signaling as a biomarker and in the pathogenesis of Ménétrier's disease. [PDF]

J Pathol
Shin M, Gabriel TT, Ofosu FK, Zhang J, Wang TT, Bechard ME, Coffey RJ, Huh WJ.   +7 more
europepmc   +1 more source

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source