Results 161 to 170 of about 956,727 (289)

Direct or indirect: the crucial role of N-palmitate in hedgehog signaling. [PDF]

Biochem Soc Trans
Puschmann J, Grobe K.
europepmc   +1 more source

GSK3α‐mediated regulation of the RNA demethylase fat mass and obesity‐associated protein (FTO) during murine spermatogenesis

The FEBS Journal, EarlyView.
FTO regulates mRNA stability and translational efficiency through its m6A‐demethylation activity. GSK3 functions as an upstream regulator of FTO, leading to its inhibition via phosphorylation. In male germ cells, FTO activity is kept in check by GSK3α.
Neha Choudhari, Budheswar Dehury, Rounak Roy, Radhakrishnan Periyasamy, Indrashis Bhattacharya, Mahesh Sahare, Srinivasan Vijayraghavan, Souvik Dey   +7 more
wiley   +1 more source

Defective neuronal differentiation in Lowe syndrome is associated with mitochondrial dysfunction and impaired cilia-related Sonic Hedgehog signaling. [PDF]

Elife
Walkiewicz G, Chen S, Lo C, Zhao J, Liu Z, Wang B, Wang Q, Kowal TJ, Lawson B, Sun Y.   +9 more
europepmc   +1 more source

The role of the adenosinergic pathway in resistance to hypomethylating agents in patients with high‐risk myelodysplastic syndromes

British Journal of Haematology, EarlyView.
George Vrachiolias, Eleftheria Lamprianidou, Athanasios Tasis, Theodoros Spyropoulos, Despoina Dimitriou, Chryssa Kymparidou, Christina Misidou, Konstantinos Liapis, Emmanouil Spanoudakis, Maria Koffa, Menelaos Papoutselis, Iliana Stamatiou, Elsa Bernard, Elli Papaemmanuil, Ioannis Mitroulis, Ioannis Kotsianidis   +15 more
wiley   +1 more source

Epigenetic control of cellular plasticity in breast cancer progression

The FEBS Journal, EarlyView.
Cancer cells undergo cell state transitions, termed plasticity, driving cancer progression and dictating therapeutic response. We define breast cancer plasticity into four interconnected processes: (1) breast cancer stem cell fates, (2) epithelial‐to‐mesenchymal transition, (3) maintenance of luminal identity, and (4) acquisition of therapeutic ...
Ellie J. Massey, Elizabeth Podleszanski, William J. Muller   +2 more
wiley   +1 more source

RXR Gamma Enables Oligodendrocyte Differentiation by Suppressing Sonic Hedgehog Signaling. [PDF]

Glia
Baldassarro VA, Brassart Q, Fraulob V, Calzà L, Krezel W.   +4 more
europepmc   +1 more source

Acyl guanidine derivatives modulating the hedgehog protein signaling pathway

, 2014
The present invention relates to acyl guanidine derivatives modulating the hedgehog protein signaling pathway to be used as drugs, in particular for treating diseases involving a tissue dysfunction associated with a deregulation of the hedgehog protein ...
Faure H., Roudaut H., MANETTI, FABRIZIO, Ruat M., TADDEI, MAURIZIO, Traiffort E., Schoenfelder A., Mann A., Solinas A.   +8 more
core  

RLIM‐associated neurodevelopmental disorders: From clinical spectrum to molecular mechanisms

The FEBS Journal, EarlyView.
RLIM (RNF12) is an E3 ubiquitin ligase essential for mammalian development. Loss‐of‐function variants cause Tønne–Kalscheuer syndrome, while duplications cause Xq13 duplication syndrome, highlighting RLIM dosage sensitivity. This review summarizes the genetics, clinical features, and molecular mechanisms of RLIM‐associated disorders, integrating ...
Madison Landon, Kyra Swildens, Vera M. Kalscheuer, Cristina Gontan, Francisco Bustos   +4 more
wiley   +1 more source

Hedgehog Signaling Regulates Hypoxia-Associated Metabolic Adaptation in Myeloid Leukemia In Vitro Cell Models. [PDF]

Int J Mol Sci
Filippi I, Monaci S, Aldinucci C, Falsini A, Bardotti M, Coppola F, Naldini A, Carraro F.   +7 more
europepmc   +1 more source

A 30‐year‐old woman with progressive lower extremity sensory loss and weakness

Brain Pathology, EarlyView.
Daniel W. Griepp, Chia‐Ming Lee, Jeffrey P. Turnbull, Sean P. Ferris, Prashant S. Kelkar   +4 more
wiley   +1 more source