Results 291 to 300 of about 113,623 (349)

DKK3 Initially Preserves Acinar Integrity Through MEK‐Fos Signaling, but Later Switches to an Oncogenic Role in Pancreatic Cancer

Advanced Science, Volume 13, Issue 3, 14 January 2026.
In pancreatic cancer, the protein DKK3 is found to play a complex role: it initially slows early tumor growth but later promotes tumor aggressiveness. DKK3 expression evolves during progression and drives cancer severity by orchestrating cellular and molecular signaling pathways.
Dharini Srinivasan, Elodie Roger, Lukas Perkhofer, Eleni Zimmer, Thomas F.E. Barth, Julia P. Mosler, Anna Härle, Stephanie E. Weissinger, Nadine T. Gaisa, Peter Möller, Nico Fischer, Chantal Allgöwer, J.‐Matthias Löhr, Dirk Grimm, Thomas Seufferlein, Stefan Liebau, Ninel Azoitei, Michael K. Melzer, Frank Arnold, Johann Gout, Alexander Kleger   +20 more
wiley   +1 more source

How Specific Signaling Pathways Like Wnt, Notch, and Hedgehog Regulate Cancer Stem Cells, and Potential Therapies Targeting These Pathways

Sameen Shahid, Syeda Hina Shah, Anisur Rahman, Ranjana H. Advani, Syeda Areeba Shiblee, Adeel-Ur-Rehman, Hina Gul   +6 more
openalex   +2 more sources

<i>TULP3</i> Regulates Proliferation and Differentiation of 3T3-L1 Preadipocytes Through the Hedgehog Signaling Pathway. [PDF]

Biology (Basel)
Jin X, Zhang Y, Wang Y, Cao H, Song Q, Huang J, Chen W, Tang H, Zeng Y.   +8 more
europepmc   +1 more source

Treatment with Minicircle DNA Expressing a FGF23 Fragment in a Clinically relevant Mouse Model of X‐Linked Hypophosphatemic Rickets

Advanced Science, Volume 13, Issue 4, 19 January 2026.
The pathogenic role of PHEX isn't fully determined, and there is no radical cure for X‐linked hypophosphatemic rickets (XLHR). This study makes the first attempt to perform gene therapy using a minicircle DNA (MC‐DNA) vector expressing a fragment of FGF23 (amino acids 180‐251) in Phex‐T1349C mice and suggests MC‐DNA as a promisingly safe and effective ...
Huixiao Wu, Wanyi Zhao, Xinyu Chen, Yanzhou Wang, Shuoshuo Wei, Bo Xiang, Yingzhou Shi, Zongyue Li, Yangyang Yao, Jin Xie, Renyuan Qiu, Meng Shu, Shuo Xu, Ping Chen, Zhiying Chen, Yingjie Wu, Weibo Xia, Ling Gao, Yongfeng Song, Jiajun Zhao, Chao Xu   +20 more
wiley   +1 more source

Astrocyte Modulation of Synaptic Plasticity Mediated by Activity-Dependent Sonic Hedgehog Signaling. [PDF]

J Neurosci
Le AD, Fu M, Carper A, Zegarowicz E, Kumar R, Zacharias G, Garcia ADR.   +6 more
europepmc   +1 more source

NUSAP1 Recruits DAXX to Suppress HIF‐Driven Triple‐Negative Breast Cancer Progression

Advanced Science, Volume 13, Issue 5, 27 January 2026.
A double‐negative feedback loop is identified in TNBC where NUSAP1 bridges HIF and DAXX via its microtubule‐associated domain (MAD) to recruit SETDB1, repressing HIF transcriptional activity by depositing the H3K9me3 repressive mark on HIF target genes, while HIF itself suppresses NUSAP1.
Yating Du, Jingjing Wang, Min Wang, Yao Zhang, Miaomiao Zheng, Huiyan Li, Xuemeng Wang, Huanran Sun, Kexin Tang, Changliang Shan, Qiang Zhao, Xiaoqian Meng, Yijie Wang, Jun Zhou, Yan Chen   +14 more
wiley   +1 more source

Buyang Huanwu Decoction enhances hippocampal-cortical connectivity remodeling via sonic hedgehog signaling to ameliorate memory dysfunction in cerebral ischemic rats. [PDF]

Chin Med
Lu Y, Lin Z, Wang H, Zhuang Y, Jia J, Wang Y, Yang L, Li M, Li M, Nie B, Zhang R, Pan X, Lei J, Zou H, Zhao H.   +14 more
europepmc   +1 more source

The High‐Altitude Adaptation Characteristics of Microbiota‐Host Cross‐Talk in Yak Gastrointestinal Track

Advanced Science, Volume 13, Issue 1, 5 January 2026.
In this study, a single‐cell atlas of 117,019 yak gastrointestinal cells across 54 subtypes identified HNF4A and SREBF2 as key transcription factors targeting MYO6 gene. Cross‐species and multi‐omics analyses reveals epithelial cells as key regulators that, through interactions with microbes, particularly Bacillus, facilitate flexible energy supply and
Chun Huang, Minghao Zhang, Qingbo Zheng, Qinran Yu, Guowu Yang, Wenwen Ren, Xiaoming Ma, Yongfu La, Pengjia Bao, Min Chu, Xian Guo, Chunnian Liang, Ping Yan   +12 more
wiley   +1 more source

Inhibition of hedgehog signaling ameliorates severity of chronic pancreatitis in experimental mouse models. [PDF]

Am J Physiol Gastrointest Liver Physiol
Iyer S, Tarique M, Sahay P, Giri S, Bava EP, Guan J, Jain T, Vaish U, Jin X, Moon S, Crossman DK, Dudeja V.   +11 more
europepmc   +1 more source

Hypothesis: Ephrin–Eph Signaling Pathways Provide Novel Targets for Accelerated Re‐Epithelialization of Cutaneous Wounds

BioEssays, Volume 48, Issue 1, January 2026.
In distal limb wounds on the horse, the proliferative phase of repair often produces excessive granulation tissue that delays healing by impeding keratinocyte migration from wound margins. This essay examines the basis for the hypothesis that ephrin–Eph signaling pathways that stimulate keratinocyte migration provide novel targets for re‐establishing ...
Rodolfo D. Vicetti Miguel, Mohan Liu, Gabriel J. Campion, Thomas L. Cherpes   +3 more
wiley   +1 more source