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The hedgehog signaling network
American Journal of Medical Genetics Part A, 2003AbstractIn the hedgehog signaling network, mutations result in various phenotypes, including, among others, holoprosencephaly, nevoid basal cell carcinoma syndrome, Pallister‐Hall syndrome, Greig cephalopolysyndactyly, Rubinstein‐Taybi syndrome, isolated basal cell carcinoma, and medulloblastoma. Active Hedgehog ligand is double lipid modified with a C‐
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Hedgehog signal transduction: recent findings
Current Opinion in Genetics & Development, 2002The Hedgehog (Hh) family of signaling molecules are key agents in patterning numerous types of tissues. Mutations in Hh and its downstream signaling molecules are also associated with numerous oncogenic and disease states. Consequently, understanding the mechanisms by which Hh signals are transduced is important for understanding both development and ...
Kent, Nybakken, Norbert, Perrimon
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Cellular and Molecular Life Sciences, 2000
Hedgehog signalling is a key regulator of embryonic development controlling proliferation and/or cell fate determination. With identification of the Hedgehog receptor PTCH1 as a tumour suppressor gene that underlies the human nevoid basal cell carcinoma syndrome (NBCCS), the Hedgehog signalling pathway was firmly linked to cancer.
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Hedgehog signalling is a key regulator of embryonic development controlling proliferation and/or cell fate determination. With identification of the Hedgehog receptor PTCH1 as a tumour suppressor gene that underlies the human nevoid basal cell carcinoma syndrome (NBCCS), the Hedgehog signalling pathway was firmly linked to cancer.
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Hedgehog: an unusual signal transducer
BioEssays, 2004AbstractHedgehog proteins are of pivotal importance for development and maintenance of tissue patterns in adult organisms. Despite the role of Hedgehogs in differentiation and tumorigenesis, signal transduction of Hedgehog remains a relatively uncharted area of signalling biochemistry.
Maarten F, Bijlsma +2 more
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2012
Der Hedgehog Signaltransduktionsweg ist konserviert von der Fliege bis zum Menschen und spielt eine wichtige Rolle in vielen Entwicklungsprozessen. Anomale Aktivierung im Erwachsenen wurde mit vielen Krebsformen in Verbindung gebracht. Unser Labor demonstrierte vor Kurzem, dass die Aktivierung von Hedgehog in weißen Adipozyten der Maus zur ...
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Der Hedgehog Signaltransduktionsweg ist konserviert von der Fliege bis zum Menschen und spielt eine wichtige Rolle in vielen Entwicklungsprozessen. Anomale Aktivierung im Erwachsenen wurde mit vielen Krebsformen in Verbindung gebracht. Unser Labor demonstrierte vor Kurzem, dass die Aktivierung von Hedgehog in weißen Adipozyten der Maus zur ...
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Hedgehog Signaling in the Prostate
Journal of Urology, 2007Recent discoveries highlight the importance of the hedgehog signaling pathway in prostate growth regulation. We reviewed the role of hedgehog signaling in prostate development, adult prostate homeostasis and prostate cancer.A comprehensive review of all relevant literature was done.Epithelial expression of hedgehog ligand during prostate development ...
Aubie, Shaw, Wade, Bushman
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Hedgehog signaling and congenital malformations
Clinical Genetics, 2004The Hedgehog (Hh)‐signaling pathway is essential for numerous developmental processes inDrosophilaand vertebrate embryos. Hh signal transduction encompasses a complex series of regulatory events, including the generation of the mature Hh ligand, propagation of the ligand from source of production as well as the reception and interpretation of the ...
E, Nieuwenhuis, C-c, Hui
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2007
TABLE OF CONTENTS Chapter 1. Purifying the Hedgehog protein and its variants by Darren P. Baker, Frederick R. Taylor and R. Blake Pepinsky Chapter 2. Application of Sonic hedgehog to the developing chick limb by Eva Tiecke and Cheryll Tickle Chapter 3.
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TABLE OF CONTENTS Chapter 1. Purifying the Hedgehog protein and its variants by Darren P. Baker, Frederick R. Taylor and R. Blake Pepinsky Chapter 2. Application of Sonic hedgehog to the developing chick limb by Eva Tiecke and Cheryll Tickle Chapter 3.
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Metabolites in vertebrate Hedgehog signaling
Biochemical and Biophysical Research Communications, 2014The Hedgehog (HH) signaling pathway is critical in embryonic development, stem cell biology, tissue homeostasis, chemoattraction and synapse formation. Irregular HH signaling is associated with a number of disease conditions including congenital disorders and cancer.
Hanne, Roberg-Larsen +3 more
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Hedgehog signalling in vascular development
Angiogenesis, 2008The Hedgehog family of proteins are powerful morphogens mediating embryonic development as well as adult morphogenesis and carcinogenesis. For example, excess hedgehog activity has been implicated in basal cell carcinoma, medulloblastoma and rhabdomyosarcoma. More recently, hedgehog signalling has been implicated in angiogenesis.
Takashi, Nagase +3 more
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