Results 321 to 330 of about 113,623 (349)
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2014
Hedgehog (Hh) signalling is important during embryonic development and adult tissue regeneration. Ectopic activation of Hh signalling leads to cancer formation and inhibitors of Hh signalling may be of therapeutic benefit. To date, studies have focused on the development of Smoothened (Smo) inhibitors, however these studies failed to address situations
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Hedgehog (Hh) signalling is important during embryonic development and adult tissue regeneration. Ectopic activation of Hh signalling leads to cancer formation and inhibitors of Hh signalling may be of therapeutic benefit. To date, studies have focused on the development of Smoothened (Smo) inhibitors, however these studies failed to address situations
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Running Interference for Hedgehog Signaling
Science Signaling, 2003The new technology of RNA interference (RNAi) is allowing high-throughput screening of cells to examine many biological processes. Michelson discusses one such system in which the Drosophila Hedgehog (Hh) pathway was analyzed by systematic genome-wide RNAi analysis. The results not only suggest unexpected overlap in
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Phosphorylation Regulation of Hedgehog Signaling
2012The study of posttranslational regulation of proteins has occupied biochemists for well over a half century. Understanding balanced phosphorylation and dephosphorylation of the proteins may be the key to meeting some of the most pressing scientific challenges. A detailed examination of the phosphorylation of many components in the Hedgehog (Hh) pathway
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Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update
Nature Reviews Clinical Oncology, 2015Lucio Miele, Sherry X Yang, S Percy Ivy
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The mechanisms of Hedgehog signalling and its roles in development and disease
Nature Reviews Molecular Cell Biology, 2013James Briscoe
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KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma
Nature Reviews Cancer, 2010Sam C Wang, Matthias Hebrok
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The Hedgehog's tale: developing strategies for targeting cancer
Nature Reviews Cancer, 2011Thomas Curran
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Hedgehog signalling in cancer formation and maintenance
Nature Reviews Cancer, 2003Marina Pasca di Magliano +1 more
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