Results 331 to 340 of about 4,715,625 (390)

The SmoA1 Mouse Model Reveals That Notch Signaling Is Critical for the Growth and Survival of Sonic Hedgehog-Induced Medulloblastomas

, 2004
Andrew R. Hallahan, Joel I. Pritchard, Stacey Hansen, M. Douglas Benson, Jennifer Stoeck, Beryl A. Hatton, Tom Russell, Richard G. Ellenbogen, Irwin D. Bernstein, Phillip A. Beachy, James M. Olson   +10 more
openalex   +2 more sources

Cerebrovascular pulsatility following long duration spaceflight is associated with changes in pulse pressure and carotid artery stiffness

Experimental Physiology, EarlyView.
Abstract Central artery stiffening increases the haemodynamic pulsations transmitted downstream towards target organs, including the brain. While recent evidence suggests that long duration spaceflight is associated with reduced common carotid artery (CCA) distensibility, cerebrovascular pulsatility has not been extensively characterized in astronauts.
Roxanne Fournier, Danielle K. Greaves, J. Kevin Shoemaker, Philippe Arbeille, Richard L. Hughson, Andrew D. Robertson   +5 more
wiley   +1 more source

Spaceborne and spaceborn: Physiological aspects of pregnancy and birth during interplanetary flight

Experimental Physiology, EarlyView.
Abstract Crewed interplanetary return missions that are on the planning horizon will take years, more than enough time for initiation and completion of a pregnancy. Pregnancy is viewed as a sequence of processes – fertilization, blastocyst formation, implantation, gastrulation, placentation, organogenesis, gross morphogenesis, birth and neonatal ...
Arun V. Holden
wiley   +1 more source

Tissue Mechanics and Hedgehog Signaling Crosstalk as a Key Epithelial-Stromal Interplay in Cancer Development. [PDF]

Adv Sci (Weinh)
Karunasagara S, Taghizadeh A, Kim SH, Kim SJ, Kim YJ, Taghizadeh M, Kim MY, Oh KY, Lee JH, Kim HS, Hyun J, Kim HW.   +11 more
europepmc   +1 more source

Mitochondrial control of ciliary gene expression and structure in striatal neurons

The Journal of Physiology, EarlyView.
Abstract figure legend Neurons drive animal behaviour by receiving and transmitting information and require energy, primarily supplied by mitochondria, to function. Additionally, neurons need to sense environmental changes to adapt, a function that is locally played by the primary cilia.
Dogukan H. Ulgen, Alessandro Chioino, Olivia Zanoletti, Albert Quintana, Elisenda Sanz, Carmen Sandi   +5 more
wiley   +1 more source

Probing the biological efficacy and mechanistic pathways of natural compounds in breast cancer therapy via the Hedgehog signaling pathway. [PDF]

J Pharm Anal
Cheng Y, Zhang W, Sun Q, Wang X, Shang Q, Liu J, Zhang Y, Liu R, Sun C.   +8 more
europepmc   +1 more source

Lobaric Acid Exhibits Anticancer Potential by Modulating the Wnt/β‐Catenin Signaling Pathway in MCF‐7 Cells

Pharmacology Research &Perspectives, Volume 13, Issue 4, August 2025.
Effect of lobaric acid on Wnt/β‐catenin pathway in breast cancer. ABSTRACT Lichen secondary metabolites with many remarkable biological activities are used in cancer treatments due to their low side effects and high anticancer potential. In particular, these metabolites constitute an interesting research area in cancer treatments due to their potential
Şeyda Nur Kalın, Kübra Nur Bayındırlı, Emine Toraman, Şükran Günaydın, Fatmanur Keleş, Ahmet Altay, Harun Budak   +6 more
wiley   +1 more source

NaHS@Cy5@MS@SP nanoparticles improve rheumatoid arthritis by inactivating the Hedgehog signaling pathway through sustained and targeted release of H₂S into the synovium. [PDF]

J Nanobiotechnology
Zhu XX, Xu AJ, Cai WW, Han ZJ, Zhang SJ, Hou B, Wen YY, Cao XY, Li HD, Du YQ, Zhuang YY, Wang J, Hu XR, Bai XR, Su JB, Zhang AY, Lu QB, Gu Y, Qiu LY, Pan L, Sun HJ.   +20 more
europepmc   +1 more source

Human sporadic breast carcinoma histotypes driven by the Human Betaretrovirus homologous to Mouse Mammary Tumor Virus

International Journal of Cancer, Volume 157, Issue 2, Page 371-383, 15 July 2025.
What's new? While estrogens, obesity, and alcohol are recognized risk factors for breast cancer, a viral hypothesis has been suggested based on the murine model of Mouse Mammary Tumor Virus (MMTV)‐induced mammary tumors. This study analyzed sequences of the human homolog of MMTV across human breast carcinoma histotypes, detecting the virus in all types
Prospero Civita, Chiara Maria Mazzanti, Francesca Lessi, Caterina Marchiò, Cristian Scatena, Michele Menicagli, Matteo Ghilli, Manuela Roncella, Antonio Giuseppe Naccarato, Anna Sapino, Jacob Hochman, Mauro Pistello, Generoso Bevilacqua   +12 more
wiley   +1 more source

Primary Cilia Formation Mediated by Hsa_Circ_0005185/OTUB1/RAB8A Complex Inhibits Prostate Cancer Progression by Suppressing Hedgehog Signaling Pathway. [PDF]

Adv Sci (Weinh)
Fan A, Zhang Y, Li Y, Meng W, Wu F, Pan W, Ma Z, Chen W.   +7 more
europepmc   +1 more source