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The Immune Checkpoint Protein PD-L1 Regulates Ciliogenesis and Hedgehog Signaling. [PDF]
CellsAgborbesong E, Li X.
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Programmed BRD9 Degradation and Hedgehog Signaling Activation via Silk-Based Core-Shell Microneedles Promote Diabetic Wound Healing. [PDF]
Adv Sci (Weinh)Liu Y +9 more
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Correction: Zeng et al. Hedgehog Signaling: Linking Embryonic Lung Development and Asthmatic Airway Remodeling. <i>Cells</i> 2022, <i>11</i>, 1774. [PDF]
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The hedgehog signaling network
American Journal of Medical Genetics, Part A, 2003AbstractIn the hedgehog signaling network, mutations result in various phenotypes, including, among others, holoprosencephaly, nevoid basal cell carcinoma syndrome, Pallister‐Hall syndrome, Greig cephalopolysyndactyly, Rubinstein‐Taybi syndrome, isolated basal cell carcinoma, and medulloblastoma. Active Hedgehog ligand is double lipid modified with a C‐
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Hedgehog Signaling Pathway [PDF]
Science's STKE, 2007 The Hedgehog (Hh) signaling pathway is essential for development and tissue homeostasis in metazoans. Probably as a result of its potent influence on cell-fate outcomes, the Hh pathway when corrupted results in malformations and diseases such as cancer. Many of the pathway components that contribute to Hh-mediated signal transduction are presented.
Lawrence G. Lum, Leni S. Jacob
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Hedgehog Signaling in the Prostate
Journal of Urology, 2007Recent discoveries highlight the importance of the hedgehog signaling pathway in prostate growth regulation. We reviewed the role of hedgehog signaling in prostate development, adult prostate homeostasis and prostate cancer.A comprehensive review of all relevant literature was done.Epithelial expression of hedgehog ligand during prostate development ...
Wade Bushman, Aubie K. Shaw
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On the range of Hedgehog signaling
Current Opinion in Genetics & Development, 2000Hedgehog (Hh) is a secreted signaling protein that regulates the development of many organ systems. It can travel from its site of synthesis, a process that involves covalent attachment of cholesterol to its carboxyl terminus, proteins with putative sterol sensing domains in both sending and receiving cells, and glycosaminoglycans.
Pao-Tien Chuang, Thomas B. Kornberg
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Cellular and Molecular Life Sciences, 2000
Hedgehog signalling is a key regulator of embryonic development controlling proliferation and/or cell fate determination. With identification of the Hedgehog receptor PTCH1 as a tumour suppressor gene that underlies the human nevoid basal cell carcinoma syndrome (NBCCS), the Hedgehog signalling pathway was firmly linked to cancer.
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Hedgehog signalling is a key regulator of embryonic development controlling proliferation and/or cell fate determination. With identification of the Hedgehog receptor PTCH1 as a tumour suppressor gene that underlies the human nevoid basal cell carcinoma syndrome (NBCCS), the Hedgehog signalling pathway was firmly linked to cancer.
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