Brain morphological analysis in mice with hyperactivation of the hedgehog signaling pathway
Frontiers in NeuroscienceHedgehog signaling is a highly conserved pathway that plays pivotal roles in morphogenesis, tumorigenesis, osteogenesis, and wound healing. Previous investigations in patients with Gorlin syndrome found low harm avoidance traits, and increased volumes in
Tadashi Shiohama +18 more
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Costal2, a Novel Kinesin-Related Protein in the Hedgehog Signaling Pathway [PDF]
, 1997 John C. Sisson +3 more
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Reduced Adult Neurogenesis in Humans Results From a Tradeoff Rather Than Direct Negative Selection
BioEssays, EarlyView.Embryonic radial glia (RG) generate neurons, glial cells, and later adult neural stem cells, which sustain adult neurogenesis (top, left to right). Human‐specific genetic modifications (blue arrow), selected to boost early RG neurogenic activity, may lead to premature RG exhaustion and reduced adult neurogenesis in the human brain (bottom).
David Morizet, Laure Bally‐Cuif
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Dynamic Compression Improves Chondrogenesis in the Tissue Engineered Model of Cartilage
Biotechnology and Bioengineering, EarlyView.ABSTRACT Hyaline cartilage is a dense avascular tissue with low regenerative potential, present at the ends of the diarthrodial joints and in the cartilage growth plate. Skeletal diseases often result from extracellular changes in this tissue; however, studies of these are hindered by the tissue complexity, the difficulty in obtaining human material ...
Marc V. Farcasanu +8 more
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Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein [PDF]
, 2000 Philip W. Ingham +6 more
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Hedgehog signaling pathway and ovarian cancer.
Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 2013 Epithelial ovarian carcinoma (EOC) is the most common form of ovarian malignancies and the most lethal gynecologic malignancy in the United States. To date, in spite of treatment to it with the extensive surgical debulking and chemotherapy, the prognosis of EOC remains dismal.
Shiwen Luo, Qi Chen, Guolan Gao
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Phosphorylation at the Helm: Kinase‐Mediated Regulation of Primary Cilia Assembly and Disassembly
Cytoskeleton, EarlyView.ABSTRACT The primary cilium serves as an antenna of most vertebrate cells and is important for conveying cues from several signaling pathways into appropriate cellular responses during development and homeostasis. Cilia assembly and disassembly processes are thought to be strictly controlled; however, the precise nature of molecular events underlying ...
Andrea Lacigová, Lukáš Čajánek
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The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway. [PDF]
, 2002 Barbara Stecca, Ariel Ruiz i Altaba
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Dynamics of primary cilia in endothelial and mesenchymal cells throughout mouse lung development
Developmental Dynamics, EarlyView.Abstract Cilia are specialized structures found on a variety of mammalian cells, with variable roles in the transduction of mechanical and biological signals (by primary cilia, PC), as well as in the generation of fluid flow (by motile cilia). Their critical role in the establishment of a left–right axis in early development is well described, as well ...
Stephen Spurgin +8 more
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SMURF1 and SMURF2 directly target GLI1 for ubiquitination and proteasome-dependent degradation
Cell Death DiscoveryThe transcription factor GLI1 is the main and final effector of the Hedgehog signaling pathway, which is involved in embryonic development, cell proliferation and stemness.
Fabio Bordin +14 more
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