Results 121 to 130 of about 3,054 (263)

A Retinoid Antagonist Attenuates Bone Growth Inhibition Caused by Growth Plate Injury in Mice

Journal of Orthopaedic Research, EarlyView.
ABSTRACT Growth plate injury, which may trigger growth plate fusion or arrest, is a common occurrence in pediatric orthopaedics that can lead to angulation of the limb and limb length discrepancy. Growth plate injuries are currently treated palliatively, with surgical intervention when severe limb length discrepancy or angulation is found during follow‐
Masatake Matsuoka, Ningfeng Tang, Tian Hongying, Kenta Uchibe, Satoru Otsuru, Norimasa Iwasaki, Joshua M. Abzug, Motomi Enomoto‐Iwamoto, Masahiro Iwamoto   +8 more
wiley   +1 more source

Investigational agents in metastatic basal cell carcinoma: focus on vismodegib

Journal of Experimental Pharmacology, 2012
Nicolas Batty,1 Ellen Kossoff,2 Grace K Dy11Department of Medicine, Roswell Park Cancer Center, Buffalo, NY, USA; 2Department of Pharmacy, Roswell Park Cancer Center, Buffalo, NY, USAAbstract: Vismodegib (GDC-0449, 2-chloro-N-(4-chloro-3-(pyridin-2-yl ...
Batty N, Kossoff E, Dy GK
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Advances in prognostic biomarkers for biliary atresia: Current insights and future directions

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Biliary atresia (BA) is a progressive, fibrosing cholangiopathy of infancy characterized by inflammatory obstruction of the bile ducts, ultimately leading to end‐stage liver disease if untreated. Early diagnosis and timely surgical intervention via hepatoportoenterostomy (HPE) are critical for improving outcomes; however, prognostication ...
Ahmad Anouti, Pavithra Sudhakara, Chelsea Pratt, Reena Mourya, Lisa VanWagner, Pranavkumar Shivakumar, Sindhu Pandurangi   +6 more
wiley   +1 more source

Insights into the Middle Pleistocene fauna of South Africa: Zooarchaeology, stable isotopes and dating of Pniel 6

Journal of Quaternary Science, EarlyView.
ABSTRACT The Florisian Land Mammal Age (FLMA; 773‐12 ka) is characterised by specialist, often extinct, grazing as well as wetland species, many of which are no longer present in the southern African interior. Middle Pleistocene FLMA faunal assemblages are rare, particularly those associated with artefacts, limiting reconstruction of environmental ...
S. Sophia Politt, Helena Pribliczki, Marc R. Dickinson, Nils Andersen, Abenicia Henderson, David Morris, Cheryl A. Makarewicz, Kirsty Penkman, Michaela Ecker   +8 more
wiley   +1 more source

Long-range sclerotome induction by sonic hedgehog: Direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway

, 1995
Chen‐Ming Fan, Jeffery A. Porter, Chin Chiang, David T. Chang, Philip A. Beachy, Marc Tessier‐Lavigne   +5 more
openalex   +1 more source

Oral Administration of Trichosanthes Kirilowii Fruit Extract Ameliorates Airway Inflammation and Suppresses Th2 Cell Activities in Ovalbumin‐Sensitized Mice

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Trichosanthes kirilowii is a plant used in traditional Chinese medicine. Its fruits, seeds, and roots can all be used medicinally. The fruit of T. kirilowii has a moistening effect on the lung for arresting cough. However, there is no scientific research to prove that the fruit of T. kirilowii can improve asthma. Herein, we evaluated whether T.
Ting‐Chi Lin, Wen‐Chung Huang, Chwan‐Fwu Lin, Wan‐Ting Chi, Shu‐Chen Cheng, Nai‐Chun Ting, Chian‐Jiun Liou   +6 more
wiley   +1 more source

Role of hedgehog signaling in the pathogenesis and therapy of heterotopic ossification

Frontiers in Cell and Developmental Biology
Heterotopic ossification (HO) is a pathological process that generates ectopic bone in soft tissues. Hedgehog signaling (Hh signaling) is a signaling pathway that plays an important role in embryonic development and involves three ligands: sonic hedgehog
Yiran Pei, Yiran Pei, Fangzhou Liu, Fangzhou Liu, Yike Zhao, Yike Zhao, Hui Lin, Xiaoyan Huang   +7 more
doaj   +1 more source

Rhaponitin Reverses Cisplatin Resistance and Impairs Cancer Stemness Through HIF‐1α/MCT4/Wnt Pathway in Tongue Squamous Cell Carcinoma

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Rhaponitin (Rha) possesses anti‐tumor activity and mediates the transcriptional activity of hypoxia‐inducible factor (HIF)‐1α that affects cisplatin (Cis) resistance. However, whether Rha can lessen Cis resistance in tongue squamous cell carcinoma (TSCC) by mediating HIF‐1α activity is unclear. Cis‐resistant SCC9 (SCC9‐CisR) cells were treated
Yuan Wu, Xiao‐Wen Wan, Lin Jiang, Wei Wang, Jia‐Jun Zhu, Yi‐Sen Shao   +5 more
wiley   +1 more source

Cell Apoptosis and Glucocorticoid‐Induced Osteonecrosis

Med Research, EarlyView.
The review identifies glucocorticoid‐induced osteocyte/osteoblast apoptosis as central to femoral head osteonecrosis (GION), mediated through STAT1‐caspase‐3, PI3K/Akt, Wnt/β‐catenin, and oxidative stress pathways. Emerging therapies targeting these pathways (e.g., HIF‐1α stabilization, AMPK activation, and exosome‐mediated miRNA delivery) show ...
Xiumei Tang, Yanyun Pang, Peijia Zhu, Zhengdong Zhang, Sen Guo, Zhijian Wei, Wenzhao Wang, Bin Ning   +7 more
wiley   +1 more source

Hedgehog signaling in cancer stem cells: a focus on hematological cancers

Stem Cells and Cloning: Advances and Applications, 2015
Victoria Campbell, Mhairi Copland Paul O'Gorman Leukaemia Research Centre, Institute of Cancer Sciences, College of Medical, Veterninary and Life Sciences, University of Glasgow, Glasgow, UK Abstract: The stem cell paradigm was first demonstrated in
Campbell V, Copl, M
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