Results 131 to 140 of about 55,819 (299)

SMURF1 and SMURF2 directly target GLI1 for ubiquitination and proteasome-dependent degradation

Cell Death Discovery
The transcription factor GLI1 is the main and final effector of the Hedgehog signaling pathway, which is involved in embryonic development, cell proliferation and stemness.
Fabio Bordin, Gloria Terriaca, Adriano Apostolico, Annamaria Di Fiore, Faranak Taj Mir, Sara Bellardinelli, Francesca Bufalieri, Rosa Bordone, Francesca Bellardinilli, Giuseppe Giannini, Gianluca Canettieri, Lucia Di Marcotullio, Elisabetta Ferretti, Marta Moretti, Enrico De Smaele   +14 more
doaj   +1 more source

The Hippo pathway acts downstream of the Hedgehog signaling to regulate follicle stem cell maintenance in the Drosophila ovary

Scientific Reports, 2017
The Hippo pathway is conserved and plays important roles in organ size control. The core components of the Hippo pathway are two kinases Hippo (Hpo), Warts (Wts), and a transcription-co-activator Yorkie (Yki). Yki activity is regulated by phosphorylation,
Ta-Hsing Hsu, Chia-Yu Yang, Tsung-Han Yeh, Yi-Chia Huang, Tsu-Wei Wang, Jenn-Yah Yu   +5 more
doaj   +1 more source

Spatiotemporal cellular dynamics of the notochord shape intervertebral disc morphogenesis in the mouse embryo through apoptosis and proliferation

Developmental Dynamics, EarlyView.
Abstract Background The notochord is a midline structure essential for vertebrate embryogenesis, contributing to the development of the nervous system, digestive tract, and vertebral column. In particular, notochord signaling is indispensable for proper patterning and coordinated development of alternating vertebrae and intervertebral discs (IVDs ...
Julie Warin, Estelle Balissat, Pauline Colombier, Lily Paillat, Maeva Dutilleul, Anne Camus   +5 more
wiley   +1 more source

Elucidating Hedgehog pathway's role in HNSCC progression: insights from a 6-gene signature

Scientific Reports
With the emergence of targeted inhibition strategies for Hedgehog signaling in cancer, multiple Hedgehog signaling pathway-related biomarkers have become the focus of research.
Yang Yang, Chenxi Yang, Qiying Yang, Shun Lu, Bisheng Liu, Dongyun Li, Dongliang Li, Peng Zhang, Peng Xu, Jinyi Lang, Jie Zhou   +10 more
doaj   +1 more source

Genome-wide analysis of gene expression and alternative splicing in human medulloblastoma

, 2010
Medulloblastoma is a malignant embryonal tumour of the cerebellum which most commonly affects children. A subset of tumours is thought to arise from cerebellar granule cell precursors (GCPs) that fail to undergo normal neuronal development, following ...
Menghi, F.
core  

Secretopathies emerge as a new class of neurocristopathies

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient embryonic population of cells that give rise to a wide range of structures, including craniofacial cartilage and bone, peripheral neurons and glia, as well as components of the cardiac outflow tract, among others.
Amanda Teixeira, Cassandra Millet‐Boureima, Joshua A. Moore, Loydie A. Jerome‐Majewska   +3 more
wiley   +1 more source

In silico analysis of putative interactions identifies fibroblasts as hubs for cell–cell communication during early regeneration of the zebrafish heart

Developmental Dynamics, EarlyView.
Abstract Background The zebrafish heart regenerates upon injury. During injury response, fibroblasts and endothelial cells accumulate at the site of damage, and cardiomyocyte cell cycle reentry allows cardiac muscle regrowth. It is relevant to understand how the different cell types communicate with each other to coordinate regeneration.
João A. S. Carvalho, Prateek Arora, Ines J. Marques, María Galardi‐Castilla, Louk Timmer, Eva van Rooij, Nadia Mercader   +6 more
wiley   +1 more source

The role of the notch signalling pathway in vascular smooth muscle cell apoptosis [PDF]

, 2004
The Notch signalling system is a highly conserved method of cell-to-cell communication involved in cell fate decisions in many cell types. Until recently, the importance of the Notch signalling pathway was recognized in the embryonic but not in the adult
Sweeney, Catherine Helena
core  

Clinical Implications of Hedgehog Pathway Signaling in Prostate Cancer

, 2015
Activity in the Hedgehog pathway, which regulates GLI-mediated transcription, is important in organogenesis and stem cell regulation in self-renewing organs, but is pathologically elevated in many human malignancies.
Daniel Suzman, Emmanuel Antonarakis
core   +1 more source

Solar Fuels Via Methane Valorization: Thermochemical Pathways, Unified Metrics, and Techno‐Economic Perspectives

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
A first‐of‐its‐kind review benchmarks three solar methane valorization pathways with unified performance metrics for clean fuel production. Meeting global climate targets and sustainable energy demands requires carbon‐neutral fuels and innovative conversion pathways.
Muhammad Abdulmoez, Amjad Othman, Majid Linjawi, Amro Al‐Qutub   +3 more
wiley   +1 more source