Results 171 to 180 of about 247,901 (376)

Revealing the Impact of Mono(2‐ethylhexyl) Phthalate (MEHP) on Prostate Cancer Based on Network Toxicology and Molecular Docking Approaches

Journal of Applied Toxicology, EarlyView.
ABSTRACT Mono(2‐ethylhexyl) phthalate (MEHP) is a ubiquitous environmental contaminant and endocrine‐disrupting chemical (EDC), identified as a potential carcinogen. Emerging studies have begun to elucidate the impact of MEHP on prostate cancer (PCa), yet its pathogenic effects and the underlying molecular mechanisms remain unclear. This study seeks to
Chenyu Liang, Weicheng Tian, Hengxi Zeng, Ziyang Xia, Zijie Luo, Yue Zhuo, Minlian Pan, Kangbu Wu, Siyu Xiong, Xuejing Lin, Xinchun Li, Jiaxi Yu   +11 more
wiley   +1 more source

Information theoretical study of cross-talk mediated signal transduction in MAPK pathways [PDF]

arXiv, 2015
Biochemical networks related to similar functional pathways are often correlated due to cross-talk among the homologous proteins in the different networks. Using a stochastic framework, we address the functional significance of the cross-talk between two pathways.
arxiv  

Embryogenesis in Myrmicine Ants Combines Features of Short Germ‐Band Development With a Progressive Mode of Segmentation

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Different insect species exhibit remarkable diversity in the developmental trajectories from fertilized eggs to hatching larvae. For three myrmicine ant species, we observe a novel combination of a developmental features: small embryonic primordia, a mode of embryogenesis termed short/intermediate germ‐band development, and progressive establishment of
Chi‐Chun Fang, Arjuna Rajakumar, Andrew Kenny, Ulrich G. Mueller, Ehab Abouheif, David Stein   +5 more
wiley   +1 more source

Elucidating Hedgehog pathway's role in HNSCC progression: insights from a 6-gene signature

Scientific Reports
With the emergence of targeted inhibition strategies for Hedgehog signaling in cancer, multiple Hedgehog signaling pathway-related biomarkers have become the focus of research.
Yang Yang, Chenxi Yang, Qiying Yang, Shun Lu, Bisheng Liu, Dongyun Li, Dongliang Li, Peng Zhang, Peng Xu, Jinyi Lang, Jie Zhou   +10 more
doaj   +1 more source

Hedgehog and Fgf signaling pathways regulate the development of tphR‐expressing serotonergic raphe neurons in zebrafish embryos [PDF]

, 2004
Hiroki Teraoka, Claire Russell, Jennifer C. Regan, Anand Chandrasekhar, Miguel L. Concha, R Yokoyama, Kyohei Higashi, Masaru Takeuchi, Wenqi Dong, Takeo Hiraga, Nakisha D. Holder, Stephen W. Wilson   +11 more
openalex   +1 more source

Oral Administration of Trichosanthes Kirilowii Fruit Extract Ameliorates Airway Inflammation and Suppresses Th2 Cell Activities in Ovalbumin‐Sensitized Mice

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Trichosanthes kirilowii is a plant used in traditional Chinese medicine. Its fruits, seeds, and roots can all be used medicinally. The fruit of T. kirilowii has a moistening effect on the lung for arresting cough. However, there is no scientific research to prove that the fruit of T. kirilowii can improve asthma. Herein, we evaluated whether T.
Ting‐Chi Lin, Wen‐Chung Huang, Chwan‐Fwu Lin, Wan‐Ting Chi, Shu‐Chen Cheng, Nai‐Chun Ting, Chian‐Jiun Liou   +6 more
wiley   +1 more source

A tale of three hedgehogs [PDF]

arXiv, 2017
In this work we study three topologies defined over the same set: the hedgehog. As the name suggests, the hedgehog can be described as a set of spines identified at a single point. Among others, we give a proof of the Kowalsky hedgehog theorem, which asserts that every metrizable space is embeddable into a countable cartesian power of the metric ...
arxiv  

Hedgehog Signaling Pathway is a New Therapeutic Target for Patients with Breast Cancer [PDF]

, 2004
Makoto Kubo, Masafumi Nakamura, Akira Tasaki, Naoki Yamanaka, Hiroshi Nakashima, Masatoshi Nomura, Syoji Kuroki, Mitsuo Katano   +7 more
openalex   +1 more source

Autonomous observations enhance our ability to observe the biological carbon pump across diverse carbon export regimes

Limnology and Oceanography, EarlyView.
Abstract The expansion of autonomous observation platforms offers vast opportunities for analyzing ocean ecosystems and their role in carbon export. As part of the EXport Processes in the Ocean from RemoTe Sensing campaign, we autonomously measured the productivity regimes in two contrasting end‐member ecosystem states.
Shawnee Traylor, David P. Nicholson, Samantha J. Clevenger, Ken O. Buesseler, Eric D'Asaro, Craig M. Lee   +5 more
wiley   +1 more source

Identification of gene pathways implicated in Alzheimer's disease using longitudinal imaging phenotypes with sparse regression [PDF]

arXiv, 2012
We present a new method for the detection of gene pathways associated with a multivariate quantitative trait, and use it to identify causal pathways associated with an imaging endophenotype characteristic of longitudinal structural change in the brains of patients with Alzheimer's disease (AD).
arxiv