Results 171 to 180 of about 834,809 (383)
Human Molecular Genetics, 2018 Cleidocranial dysplasia (CCD, #119600), which is characterized by hypoplastic clavicles, open fontanelles, supernumerary teeth and a short stature, is caused by heterozygous mutations in RUNX2.
Xin Qin +3 more
semanticscholar +1 more source
How Growth Cones Sense Extracellular Cues and Drive Neuronal Migration
BioEssays, EarlyView.Migrating neurons and growing axons utilize structurally and functionally similar growth cones to detect guidance cues. Shared receptors and signaling pathways mediate cytoskeletal reorganization to direct movement. This conserved mechanism underlies both neuronal migration and axon extension, providing insights into neuronal development and potential ...
Takahiro Kanzawa +3 more
wiley +1 more source
Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein [PDF]
, 2000 Philip W. Ingham +6 more
openalex +1 more source
Phosphorylation at the Helm: Kinase‐Mediated Regulation of Primary Cilia Assembly and Disassembly
Cytoskeleton, EarlyView.ABSTRACT The primary cilium serves as an antenna of most vertebrate cells and is important for conveying cues from several signaling pathways into appropriate cellular responses during development and homeostasis. Cilia assembly and disassembly processes are thought to be strictly controlled; however, the precise nature of molecular events underlying ...
Andrea Lacigová, Lukáš Čajánek
wiley +1 more source
The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway. [PDF]
, 2002 Barbara Stecca, Ariel Ruiz i Altaba
openalex +1 more source
Identification of Anoikis‐Related Subgroups and Prognosis Model in Colon Cancer
Cancer Nexus, EarlyView.ABSTRACT Background Anoikis represents a distinct type of programmed cell death that serves a critical function in tumor development and metastatic. Despite its significance, there remains a notable gap in comprehensive studies that explore the role of Anoikis specifically within the context of colon cancer (CC). Thus, it becomes imperative to pinpoint
Shaokang Yang +5 more
wiley +1 more source
SMURF1 and SMURF2 directly target GLI1 for ubiquitination and proteasome-dependent degradation
Cell Death DiscoveryThe transcription factor GLI1 is the main and final effector of the Hedgehog signaling pathway, which is involved in embryonic development, cell proliferation and stemness.
Fabio Bordin +14 more
doaj +1 more source
Scientific Reports, 2017 The Hippo pathway is conserved and plays important roles in organ size control. The core components of the Hippo pathway are two kinases Hippo (Hpo), Warts (Wts), and a transcription-co-activator Yorkie (Yki). Yki activity is regulated by phosphorylation,
Ta-Hsing Hsu +5 more
doaj +1 more source
Gli Proteins: Regulation in Development and Cancer
Cells, 2019 Gli proteins are transcriptional effectors of the Hedgehog signaling pathway. They play key roles in the development of many organs and tissues, and are deregulated in birth defects and cancer. We review the molecular mechanisms of Gli protein regulation
Paweł Niewiadomski +5 more
doaj +1 more source
Dynamics of primary cilia in endothelial and mesenchymal cells throughout mouse lung development
Developmental Dynamics, EarlyView.Abstract Cilia are specialized structures found on a variety of mammalian cells, with variable roles in the transduction of mechanical and biological signals (by primary cilia, PC), as well as in the generation of fluid flow (by motile cilia). Their critical role in the establishment of a left–right axis in early development is well described, as well ...
Stephen Spurgin +8 more
wiley +1 more source