Results 171 to 180 of about 55,819 (299)

Targeting the Hedgehog Signaling Pathway in the Retina Using Quercetin-Loaded Lipid Nanoparticles for Myopia Control. [PDF]

Transl Vis Sci Technol
Zhao L, Guo B, Dong X, Du Y, Xu Z, Song Y, Feng J, Zhang A, Qu Y, Song J, Bi H.   +10 more
europepmc   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

[Corrigendum] Astragaloside IV promotes the proliferation and migration of osteoblast‑like cells through the hedgehog signaling pathway. [PDF]

Int J Mol Med
Guo LH, Cao Y, Zhuang RT, Han Y, Li J.
europepmc   +1 more source

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source

Targeting the Hedgehog and Notch Signaling Pathways [PDF]

Journal of Thoracic Oncology, 2011
openaire   +2 more sources

[Retracted] Hsp90 inhibitor 17‑AAG inhibits stem cell‑like properties and chemoresistance in osteosarcoma cells via the Hedgehog signaling pathway. [PDF]

Oncol Rep
Shu X, Liu H, Zhen R, Jie Y, Chen L, Qi H, Wang C, Wang R, Chen D, Ran Y.   +9 more
europepmc   +1 more source

The sorting nexin Snx21 promotes flotillin‐mediated endocytosis

The FEBS Journal, EarlyView.
In this study, we describe a novel function of the previously uncharacterized Snx21 protein as a specific positive regulator of flotillin‐mediated endocytic trafficking. Snx21 is recruited to endosomal membranes via binding to PI(3)P, and it colocalizes with flotillins on the surface of late endosomes.
Tamás Maruzs, Enikő Lakatos, Dalma Feil‐Börcsök, Gábor Juhász, Regina Mező, Asha Kiran Maddali, András Blastyák, Aladár Pettkó‐Szandtner, Hajnalka Laczkó‐Dobos, Gábor Juhász   +9 more
wiley   +1 more source

Targeting the hedgehog signaling pathway to improve tendon-to-bone integration. [PDF]

Osteoarthritis Cartilage, 2023
Kamalitdinov TB, Fujino K, Keith Lang S, Jiang X, Madi R, Evans MK, Zgonis MH, Kuntz AF, Dyment NA.   +8 more
europepmc   +1 more source

Stable Isotope–Enabled Particle Drift Models Predict Where High‐Resolution Isotope Analyses Can Discriminate Among Larval Trajectories in Atlantic Mackerel

Fisheries Oceanography, EarlyView.
ABSTRACT Marine fish commonly move across distinct habitats throughout their lifetimes, particularly during larval stages, when they are particularly difficult to track. Such transitions are necessary as environmental demands and predation pressures change dramatically with increases in body size.
Yuan Tian Chou, Robert Marsh, Ewan Hunter, Clive N. Trueman   +3 more
wiley   +1 more source

Repressing the hedgehog signalling pathway

, 2007
The Hedgehog (Hh) signalling pathway is essential for metazoan development and aberrant activation of the pathway is found in tumours. Mutations in Hh pathway components are found in several tumour types, including basal cell carcinoma (BCC) and medulloblastoma (MB). The outline of the Hh pathway is evolutionary conserved, with Patched (Ptch) as the Hh
openaire   +1 more source