Results 211 to 220 of about 247,901 (376)

Non-Canonical Hedgehog Signaling Is a Positive Regulator of the WNT Pathway and Is Required for the Survival of Colon Cancer Stem Cells

Cell Reports, 2017
Summary: Colon cancer is a heterogeneous tumor driven by a subpopulation of cancer stem cells (CSCs). To study CSCs in colon cancer, we used limiting dilution spheroid and serial xenotransplantation assays to functionally define the frequency of CSCs in ...
Joseph L. Regan, Dirk Schumacher, Stephanie Staudte, Andreas Steffen, Johannes Haybaeck, Ulrich Keilholz, Caroline Schweiger, Nicole Golob-Schwarzl, Dominik Mumberg, David Henderson, Hans Lehrach, Christian R.A. Regenbrecht, Reinhold Schäfer, Martin Lange   +13 more
doaj  

A luminal non‐coding RNA‐based genomic classifier confirms favourable outcomes in patients with clinically organ‐confined bladder cancer treated with radical cystectomy

BJU International, Volume 135, Issue 4, Page 648-656, April 2025.
Objective To further evaluate a genomic classifier (GC) in a cohort of patients undergoing radical cystectomy (RC), as long non‐coding RNA (lncRNA)‐based genomic profiling has suggested utility in identifying a distinct tumour subgroup corresponding to a favourable prognosis in patients with bladder cancer.
Joep J. de Jong, James A. Proudfoot, Siamak Daneshmand, Robert S. Svatek, Vikram Narayan, Ewan A. Gibb, Elai Davicioni, Shreyas Joshi, Aaron Dahmen, Roger Li, Brant A. Inman, Paras Shah, Iftach Chaplin, Jonathan Wright, Yair Lotan   +14 more
wiley   +1 more source

Indian hedgehog signaling pathway: Expression and regulation in pancreatic cancer

, 2004
Hany Kayed, Jörg Kleeff, Shereen Keleg, Junchau Guo, Knut Ketterer, Pascal O. Berberat, Nathalia A. Giese, Iréne Esposito, Thomas Giese, Markus W. Büchler, Helmut Frieß   +10 more
openalex   +1 more source

Itraconazole inhibits proliferation, induces apoptosis, and reduces angiogenesis of hemangioma endothelial cells by downregulating the hedgehog signaling pathway. [PDF]

Heliyon, 2023
Dong J, Cui J, Shi X, Wang T, Liu S.
europepmc   +1 more source

Dominant Activation of the Hedgehog Signaling Pathway in the Ovary Alters Theca Development and Prevents Ovulation [PDF]

, 2009
Yi Ren, Robert G. Cowan, Rebecca M. Harman, Susan M. Quirk   +3 more
openalex   +1 more source

System level network data and models attack cancer drug resistance

British Journal of Pharmacology, EarlyView.
Drug resistance is responsible for >90% of cancer related deaths. Cancer drug resistance is a system level network phenomenon covering the entire cell. Small‐scale interactomes and signalling network models of drug resistance guide directed drug development.
Márk Kerestély, Dávid Keresztes, Levente Szarka, Borbála M. Kovács, Klára Schulc, Dániel V. Veres, Peter Csermely   +6 more
wiley   +1 more source

Baicalin attenuates dexamethasone-induced apoptosis of bone marrow mesenchymal stem cells by activating the hedgehog signaling pathway. [PDF]

Chin Med J (Engl), 2023
Jia B, Jiang Y, Yao Y, Xu Y, Wang Y, Li T.   +5 more
europepmc   +1 more source

Epidermal Growth Factor Receptor Signaling Synergizes with Hedgehog/GLI in Oncogenic Transformation via Activation of the MEK/ERK/JUN Pathway [PDF]

, 2009
Harald Schnidar, Markus Eberl, Stefan Klingler, Doris Mangelberger, Maria Kasper, Cornelia Hauser‐Kronberger, Gerhard Regl, Renate Kroismayr, Richard Moriggl, Maria Sibilia, Fritz Aberger   +10 more
openalex   +1 more source

GPCR‐G protein signalling and its mutational landscape in cancer—Driver or passenger

British Journal of Pharmacology, EarlyView.
G protein‐coupled receptors (GPCRs) play a crucial role in cellular signalling, regulating various physiological processes. Abnormal expression and mutations of GPCRs have been implicated in several types of cancer, influencing tumour initiation, progression and immune response.
Chenlin Feng, Jasper F. Ooms, Erik H. J. Danen, Laura H. Heitman   +3 more
wiley   +1 more source

Role of the hedgehog signaling pathway in rheumatic diseases: An overview. [PDF]

Front Immunol, 2022
Su Y, Xing H, Kang J, Bai L, Zhang L.
europepmc   +1 more source