Results 221 to 230 of about 834,809 (383)

The sonic hedgehog signaling pathway is reactivated in human renal cell carcinoma and plays orchestral role in tumor growth [PDF]

, 2009
Valérian Dormoy, Sabrina Danilin, Véronique Lindner, Lionel Thomas, Sylvie Rothhut, Catherine Coquard, Jean‐Jacques Helwig, Didier Jacqmin, Hervé Lang, Thierry Massfelder   +9 more
openalex   +1 more source

Manipulation of Wnt/β‐Catenin Signaling by Synthetic Frizzled Agonist and LRP Antagonist in Organoid Cultures and In Vivo

Small Methods, EarlyView.
Harnessing synthetic key receptor modulators, this study presents a breakthrough in Wnt/β‐catenin regulation. The FZD agonist RRP‐pbFn bypasses LRP5/6 to drive organoid expansion and tissue regeneration, while the LRP antagonist RRP‐Dkk1c eradicates tumors. These tools enable precise pathway control, advancing regenerative and cancer therapies.
Quanhui Dai, Jiawen Wang, Zihuan Lin, Danni Yu, Hui Yang, Jinsong Wei, Xiaoyu Li, Hao Hu, Chao Ni, Bing Zhao   +9 more
wiley   +1 more source

Non-Canonical Hedgehog Signaling Is a Positive Regulator of the WNT Pathway and Is Required for the Survival of Colon Cancer Stem Cells

Cell Reports, 2017
Summary: Colon cancer is a heterogeneous tumor driven by a subpopulation of cancer stem cells (CSCs). To study CSCs in colon cancer, we used limiting dilution spheroid and serial xenotransplantation assays to functionally define the frequency of CSCs in ...
Joseph L. Regan, Dirk Schumacher, Stephanie Staudte, Andreas Steffen, Johannes Haybaeck, Ulrich Keilholz, Caroline Schweiger, Nicole Golob-Schwarzl, Dominik Mumberg, David Henderson, Hans Lehrach, Christian R.A. Regenbrecht, Reinhold Schäfer, Martin Lange   +13 more
doaj  

Targeting the Hedgehog and Notch Signaling Pathways [PDF]

Journal of Thoracic Oncology, 2011
openaire   +3 more sources

Nanotechnology and cell death: Revolutionizing disease treatment with nanoparticle strategies

VIEW, EarlyView.
Traditional disease treatments often face issues such as poor drug targeting and significant side effects, with many complex diseases lacking effective therapies. Our research utilizes tiny nanomaterials to treat diseases by regulating natural cell death processes, improving the immune environment, etc., enabling drugs to act more precisely.
Yiwen Wan, Wangzheqi Zhang, Yan Liao, Chenglong Zhu, Xiaojing Guo, Zui Zou, Mi Li   +6 more
wiley   +1 more source

The Hedgehog Signalling Pathway in the Gastrointestinal Tract: Implications for Development, Homeostasis, and Disease

, 2005
Charlie W. Lees, Sarah Howie, R. Balfour Sartor, Jack Satsangi   +3 more
openalex   +2 more sources

Activation of the Hedgehog signaling pathway leads to fibrosis in aortic valves. [PDF]

Cell Biosci, 2023
Gu D, Soepriatna AH, Zhang W, Li J, Zhao J, Zhang X, Shu X, Wang Y, Landis BJ, Goergen CJ, Xie J.   +10 more
europepmc   +1 more source

Improving the integration of artificial intelligence into existing ecological inference workflows

Methods in Ecology and Evolution, EarlyView.
Abstract Artificial intelligence (AI) has revolutionised the process of identifying species and individuals in audio recordings and camera trap images. However, despite developments in sensor technology, machine learning and statistical methods, a general AI‐assisted data‐to‐inference pipeline has yet to emerge. We argue that this is, in part, due to a
Amber Cowans, Xavier Lambin, Darragh Hare, Chris Sutherland   +3 more
wiley   +1 more source

Dominant Activation of the Hedgehog Signaling Pathway in the Ovary Alters Theca Development and Prevents Ovulation [PDF]

, 2009
Yi Ren, Robert G. Cowan, Rebecca M. Harman, Susan M. Quirk   +3 more
openalex   +1 more source

The Transcriptome Trajectory Reveals Sex‐ and Age‐Dependent Changes in the Mouse Adrenal Gland

Aging Cell, EarlyView.
This comprehensive RNA‐seq dataset reveals the sex‐ and age‐dependent gene expression profile of the mouse adrenal gland. It helps identify novel marker genes of the adrenal inner cortex, offering new insights into the organ's development and aging process.
Hui Wang, Ben Maggard, Huifei Sophia Zheng, Yuan Kang, Chen‐Che Jeff Huang   +4 more
wiley   +1 more source