Results 231 to 240 of about 834,809 (383)

Small‐Molecule Inhibitors of the Hedgehog Signaling Pathway as Cancer Therapeutics [PDF]

, 2010
Stefan Peukert, Karen Miller‐Moslin
openalex   +1 more source

Itraconazole inhibits proliferation, induces apoptosis, and reduces angiogenesis of hemangioma endothelial cells by downregulating the hedgehog signaling pathway. [PDF]

Heliyon, 2023
Dong J, Cui J, Shi X, Wang T, Liu S.
europepmc   +1 more source

Skeletal Maturity and Age‐Related Changes in Immune Cells and Circulatory Factors Impair Large‐Scale Bone Regeneration

Aging Cell, EarlyView.
Although the ribs are the only human bones capable of regenerating large‐scale defects, this remarkable ability declines with skeletal maturity and age. Here, we reproduce skeletal maturity and age‐related phenotypic changes in a mouse model of rib resection.
Luciana Yamamoto de Almeida, Catharine Dietrich, Ashleigh S. Hanner, Katelyn M. McTighe, Daniel Martin, NIDCD/NIDCR Genomics and Computational Biology Core, Todd Fairbanks, Thomas M. Link, John M. Le, Natasha Curry, Priyam Jani, Xin Gao, Wenli Yu, Francesca V. Mariani, Olivier Duverger, Janice S. Lee   +15 more
wiley   +1 more source

Hedgehog signaling pathway and gastrointestinal stem cell signaling network (Review)

, 2006
Yuriko Katoh, Masaru Katoh
openalex   +2 more sources

A luminal non‐coding RNA‐based genomic classifier confirms favourable outcomes in patients with clinically organ‐confined bladder cancer treated with radical cystectomy

BJU International, Volume 135, Issue 4, Page 648-656, April 2025.
Objective To further evaluate a genomic classifier (GC) in a cohort of patients undergoing radical cystectomy (RC), as long non‐coding RNA (lncRNA)‐based genomic profiling has suggested utility in identifying a distinct tumour subgroup corresponding to a favourable prognosis in patients with bladder cancer.
Joep J. de Jong, James A. Proudfoot, Siamak Daneshmand, Robert S. Svatek, Vikram Narayan, Ewan A. Gibb, Elai Davicioni, Shreyas Joshi, Aaron Dahmen, Roger Li, Brant A. Inman, Paras Shah, Iftach Chaplin, Jonathan Wright, Yair Lotan   +14 more
wiley   +1 more source

System level network data and models attack cancer drug resistance

British Journal of Pharmacology, EarlyView.
Drug resistance is responsible for >90% of cancer related deaths. Cancer drug resistance is a system level network phenomenon covering the entire cell. Small‐scale interactomes and signalling network models of drug resistance guide directed drug development.
Márk Kerestély, Dávid Keresztes, Levente Szarka, Borbála M. Kovács, Klára Schulc, Dániel V. Veres, Peter Csermely   +6 more
wiley   +1 more source

Synthetic microneurotrophins: Neurotrophin receptors for therapeutics of neurodegenerative diseases

British Journal of Pharmacology, EarlyView.
Neurodegenerative disorders are characterised by the chronic progressive degeneration of specific neuronal subtypes, neuroinflammation, myelin damage and synaptic loss. Despite their growing incidence, advancements in effective treatments remain limited, because of lack of knowledge for the aetiology of the diverse pathophysiology to design systematic ...
Ioanna Zota, Theodora Calogeropoulou, Konstantina Chanoumidou, Ioannis Charalampopoulos, Achille Gravanis   +4 more
wiley   +1 more source

Beyond synapses: cytoplasmic connections in brain function and evolution

Biological Reviews, EarlyView.
ABSTRACT Following Ramón y Cajal's groundbreaking contributions to the identification of synapses, research in neuroscience predominantly focused on their pivotal role in neural communication (the neuron doctrine), overlooking an intriguing possibility suggested by Golgi of non‐synaptic interactions among neural cells.
Malalaniaina Rakotobe, Chiara Zurzolo
wiley   +1 more source

How Do Cancer Cells Create Cancer‐Associated Fibroblast Subtypes? Impacts of Extracellular Vesicles on Stromal Diversity

Cancer Science, EarlyView.
Cancer‐associated fibroblasts (CAFs) are the major component of the tumor stroma. This review will highlight the CAF subtypes within the tumor microenvironment and their role in tumor progression. CAF subtype induction by extracellular vesicles (EVs) and their significance, which we reported previously, are also discussed.
Yutaka Naito
wiley   +1 more source

PRRX2 Regulates GLI2 to Promote Proliferation, Invasion, and Metastasis by Inhibiting Senescence via Hedgehog Signaling

Cancer Science, EarlyView.
PRRX2 is highly expressed in pancreatic cancer and correlates with patient prognosis. PRRX2 promotes pancreatic cancer cell proliferation, invasion, and metastasis, and inhibits pancreatic cancer cell senescence. PRRX2 transcriptionally regulates GLI2 and activates the Hedgehog pathway.
Wei Huang, Feiqiang xu, Jichuan xu, Gang Quan, Shihang zhang, Mengmeng guo, Feng xiao, Jianxin jiang   +7 more
wiley   +1 more source