Results 271 to 280 of about 51,121 (302)

Hedgehog signaling pathway in neural development and disease

Psychoneuroendocrinology, 2007
A number of developmental cues underlie proper brain morphogenesis and plasticity. Hedgehog (Hh) signaling pathway plays a critical role in determining proper embryonic patterning and cell fate determination in the central nervous system. Embryonic and adult neural progenitor cells are mostly responsive to Hh signaling, thereby sustaining developmental
GULINO, Alberto, DI MARCOTULLIO, LUCIA, FERRETTI, ELISABETTA, DE SMAELE, Enrico, SCREPANTI, Isabella   +4 more
openaire   +3 more sources

Pentoxifylline inhibits liver fibrosis via hedgehog signaling pathway

Journal of Huazhong University of Science and Technology [Medical Sciences], 2016
Infection of schistosomiasis japonica may eventually lead to liver fibrosis, and no effective antifibrotic therapies are available but liver transplantation. Hedgehog (HH) signaling pathway has been involved in the process and is a promising target for treating liver fibrosis.
Hui, Li, Juan, Hua, Chun-Xia, Guo, Wei-Xian, Wang, Bao-Ju, Wang, Dong-Liang, Yang, Ping, Wei, Yin-Ping, Lu   +7 more
openaire   +2 more sources

Wnt and Hedgehog Signaling Pathways in Bone Development

Journal of Bone and Joint Surgery, 2008
Cell-cell signaling is a major strategy that vertebrate embryos employ to coordinately control cell proliferation, differentiation, and survival in many developmental processes. Similar cell signaling pathways also control adult tissue regeneration and repair.
Timothy F, Day, Yingzi, Yang
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[Hedgehog signaling pathway and osteoporosis].

Zhongguo gu shang = China journal of orthopaedics and traumatology, 2014
Hedgehog signaling pathway is a conserved and important signaling pathway involved in proliferation and differentiation of many types of cells. Latest studies have found that Hedgehog signaling pathway may induce MSCs osteoblast differentiation by increasing the expression of the Runx2 and Osx and inhibit MSCs differentiate to adipocyte.
Ming, Luo, Hong-Xing, Huang, Hong, Huang, Ze-Tian, Li, Yuan-Yuan, Lai   +4 more
openaire   +1 more source

GDC-0449 - Targeting the Hedgehog Signaling Pathway

2009
Hedgehog signaling is activated in a variety of solid tumors and hematologic malignancies by point mutations in hedgehog pathway members or autocrine or paracrine ligand secretion. Several hedgehog inhibitors were developed to block hedgehog pathway activity on the level of the activating receptor, Smoothened (Smo).
openaire   +2 more sources

The Hedgehog and Wnt signalling pathways in cancer

Nature, 2001
The Wnt and Hedgehog (Hh) signalling pathways have long been known to direct growth and patterning during embryonic development. Recent evidence also implicates these pathways in the postembryonic regulation of stem-cell number in epithelia such as those of the skin and intestine, which undergo constant renewal.
J, Taipale, P A, Beachy
openaire   +2 more sources

Similarities between the Hedgehog and Wnt signaling pathways

Trends in Cell Biology, 2002
Hedgehog and Wnt proteins are signaling molecules that direct many aspects of metazoan development through signal transduction pathways that are just beginning to be understood. Recently, the common use of glycogen synthase kinase 3 and casein kinase 1 has been added to a growing list of straightforward similarities between Hedgehog and Wnt signaling ...
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Hedgehog signalling: Emerging evidence for non-canonical pathways

Cellular Signalling, 2009
Hedgehog (HH) signalling is involved in the development of numerous embryonic tissues. In humans,germline mutations in hedgehog pathway components cause congenital malformations and somatic mutations are associated with cancers. The basic framework of the HH pathway was elucidated in the fruitfly, Drosophila melanogaster, and this pathway is largely ...
openaire   +2 more sources

[Hedgehog signaling pathway and human disorders].

No to hattatsu = Brain and development, 2009
The hedgehog signaling pathway plays pivotal roles in embryonic development and cancer formation. This pathway in mammals consists of multiple molecules such as Sonic Hedgehog, PTCH, SMO, and GLI. Mutations of these components result in various human malformations or tumors, i.e., holoprosencephaly, Gorlin syndrome, Greig encephalopolysyndactyly ...
Katsunori, Fujii, Toshiyuki, Miyashita
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Hedgehog signaling pathways in multiple myeloma

Annals of Research in Oncology, 2022
I. Dulcamare, S. Giallongo, N. Vicario, G. Scandura, A. Barbato, E. La Spina, L. Longhitano, D. Cambria, D. Tibullo, T. Zuppelli, D. Lo Furno, R. Parenti, G. Li Volti, G. A. Palumbo, F. Di Raimondo, A. Romano, C. Giallongo   +16 more
openaire   +2 more sources