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Targeting Hedgehog signaling pathway: Paving the road for cancer therapy

Pharmacological Research, 2019
The Hedgehog pathway is essential for embryonic development but also for tissue and organ homeostasis in adult organisms. Activation of this pathway leads to the expression of target genes involved in proliferation, angiogenesis and stem cell self ...
Ioana Berindan-Neagoe, Farzaneh Hadjiakhoondi, Azadeh Manayi   +2 more
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Hedgehog Signaling Pathway

Science's STKE, 2007
The Hedgehog (Hh) signaling pathway is essential for development and tissue homeostasis in metazoans. Probably as a result of its potent influence on cell-fate outcomes, the Hh pathway when corrupted results in malformations and diseases such as cancer. Many of the pathway components that contribute to Hh-mediated signal transduction are presented.
Leni, Jacob, Lawrence, Lum
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Modulators of the hedgehog signaling pathway

Bioorganic & Medicinal Chemistry, 2010
Since its discovery by C. Nüsslein-Volhard and E. F. Wieschaus, hedgehog (hh) signaling has come a long way. Today it is regarded as a key regulator in embryogenesis where it governs processes like cell proliferation, differentiation, and tissue patterning. Furthermore, in adults it is involved in the maintenance of stem cells, and in tissue repair and
Philipp, Heretsch, Lito, Tzagkaroulaki, Athanassios, Giannis   +2 more
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The Hedgehog Signaling Pathway in Cancer

2005
The Hedgehog (Hh) signaling pathway plays crucial roles during embryonic development, where it controls cell proliferation, differentiation, and tissue patterning in numerous tissues and organs (Ingham and McMahon 2001; Cohen 2003). Mutations in genes encoding key members of the pathway can result in many human developmental disorders, including ...
Janni, Vestergaard, Mads, Bak, Lars Allan, Larsen   +2 more
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Potent Inhibitors of the Hedgehog Signaling Pathway

Journal of Medicinal Chemistry, 2008
A small family of phenyl quinazolinone ureas is reported as potent modulators of Hedgehog protein function. Preliminary SAR studies of the urea substituent led to a nanomolar Hedgehog antagonist.
Shirley A, Brunton, John H A, Stibbard, Lee L, Rubin, Lawrence I, Kruse, Oivin M, Guicherit, Edward A, Boyd, Steven, Price   +6 more
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Hedgehog Signaling Pathway in Drosophila

Science's STKE, 2007
Studies in Drosophila have provided the framework for understanding human development and disease processes governed by the Hedgehog (Hh) family of secreted signaling molecules. The Drosophila proteins that participate in Hh-mediated signal transduction are highlighted in a Connections Map ...
Leni, Jacob, Lawrence, Lum
openaire   +2 more sources

The Hedgehog and Wnt signalling pathways in cancer

Nature, 2001
The Wnt and Hedgehog (Hh) signalling pathways have long been known to direct growth and patterning during embryonic development. Recent evidence also implicates these pathways in the postembryonic regulation of stem-cell number in epithelia such as those of the skin and intestine, which undergo constant renewal.
J, Taipale, P A, Beachy
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Hedgehog signaling pathway in neuroblastoma differentiation

Journal of Pediatric Surgery, 2010
The hedgehog (Hh) signaling pathway is activated in some adult cancers. On the other hand, the Hh signaling pathway plays an important role in the development of the neural crest in embryos. The aim of this study is to show the activation of Hh signaling pathway in neuroblastoma (NB), a pediatric malignancy arising from neural crest cells, and to ...
Ryota, Souzaki, Tatsuro, Tajiri, Masae, Souzaki, Yoshiaki, Kinoshita, Sakura, Tanaka, Kenichi, Kohashi, Yoshinao, Oda, Mitsuo, Katano, Tomoaki, Taguchi   +8 more
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The Hedgehog signalling pathway and cancer

The Journal of Pathology, 2001
The Hedgehog signalling pathway is important in embryological development and is highly conserved through evolution. Recently Patched, a member of the pathway, was found to be important in Gorlin's syndrome. Inherited Patched gene mutations underlie the syndrome, in which a key feature is multiple basal cell carcinomas (BCCs).
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Potent agonists of the Hedgehog signaling pathway

Bioorganic & Medicinal Chemistry Letters, 2009
A family of biaryl substituted 1,4-diaminocyclohexanamides of 3-chlorobenzothiophene-2-carboxylic acid is reported as picomolar modulators of Hedgehog protein function. SAR for the 1,4-diaminocyclohexane group is shown to be exquisitely sensitive to substitution on the 4-amino group, and SAR for the 3-chlorobenzothiophene group is highly specific ...
Shirley A, Brunton, John H A, Stibbard, Lee L, Rubin, Oivin M, Guicherit, Lawrence I, Kruse, Stephen, Price, Raffaella, di Lucrezia, Colin H, MacKinnon, Alaric, Avery, Yvonne, Park, Danielle, Buxton, Edward A, Boyd   +11 more
openaire   +2 more sources