Results 271 to 280 of about 55,819 (299)

Hedgehog signaling pathway in neural development and disease

Psychoneuroendocrinology, 2007
A number of developmental cues underlie proper brain morphogenesis and plasticity. Hedgehog (Hh) signaling pathway plays a critical role in determining proper embryonic patterning and cell fate determination in the central nervous system. Embryonic and adult neural progenitor cells are mostly responsive to Hh signaling, thereby sustaining developmental
GULINO, Alberto, DI MARCOTULLIO, LUCIA, FERRETTI, ELISABETTA, DE SMAELE, Enrico, SCREPANTI, Isabella   +4 more
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Intricacies of hedgehog signaling pathways: A perspective in tumorigenesis

Experimental Cell Research, 2012
The hedgehog (HH) signaling pathway is a crucial negotiator of developmental proceedings in the embryo governing a diverse array of processes including cell proliferation, differentiation, and tissue patterning. The overall activity of the pathway is significantly curtailed after embryogenesis as well as in adults, yet it retains many of its functional
Swayamsiddha, Kar, Moonmoon, Deb, Dipta, Sengupta, Arunima, Shilpi, Sujit Kumar, Bhutia, Samir Kumar, Patra   +5 more
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Wnt and Hedgehog Signaling Pathways in Bone Development

Journal of Bone and Joint Surgery, 2008
Cell-cell signaling is a major strategy that vertebrate embryos employ to coordinately control cell proliferation, differentiation, and survival in many developmental processes. Similar cell signaling pathways also control adult tissue regeneration and repair.
Timothy F, Day, Yingzi, Yang
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The Sonic Hedgehog Signaling Pathway

2008
Abstract The highly conserved hedgehog (Hh) family of signaling proteins triggers crucial processes in early vertebrate and invertebrate development, including cell fate speci7cation, patterning, and organogenesis. The development of a large number of organ systems is directly affected by the Hh signaling pathway. Indeed, the Hh ligands,
Philip Iannaccone, Robert Holmgren, Marilyn L G Lamm, Sara Ahlgren, Olga Lakiza, Joon Won Yoon,, David Walterhouse   +6 more
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Overview of Hedgehog Signaling Pathway

2011
Initially discovered in Drosophila and later found in all vertebrate model organisms, the Hedgehog (Hh) family of secreted proteins plays critical roles in both embryonic development and adult tissue homeostasis [41, 84]. Numerous human genetic disorders and cancer have been associated with aberrant Hh signaling activity [41, 63, 84].
Chi-chung Hui, Jin Jiang
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Not Lost in Space: Trafficking in the Hedgehog Signaling Pathway

Science Signaling, 2010
Protein kinase A orchestrates Hedgehog signaling from the base of the primary cilium.
Ljiljana, Milenkovic, Matthew P, Scott
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Similarities between the Hedgehog and Wnt signaling pathways

Trends in Cell Biology, 2002
Hedgehog and Wnt proteins are signaling molecules that direct many aspects of metazoan development through signal transduction pathways that are just beginning to be understood. Recently, the common use of glycogen synthase kinase 3 and casein kinase 1 has been added to a growing list of straightforward similarities between Hedgehog and Wnt signaling ...
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[Hedgehog signaling pathway and osteoporosis].

Zhongguo gu shang = China journal of orthopaedics and traumatology, 2014
Hedgehog signaling pathway is a conserved and important signaling pathway involved in proliferation and differentiation of many types of cells. Latest studies have found that Hedgehog signaling pathway may induce MSCs osteoblast differentiation by increasing the expression of the Runx2 and Osx and inhibit MSCs differentiate to adipocyte.
Ming, Luo, Hong-Xing, Huang, Hong, Huang, Ze-Tian, Li, Yuan-Yuan, Lai   +4 more
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Multiple roles for lipids in the Hedgehog signalling pathway

Nature Reviews Molecular Cell Biology, 2008
The identification of endogenous sterol derivatives that modulate the Hedgehog (Hh) signalling pathway has begun to suggest testable hypotheses for the cellular biological functions of Patched, and for the lipoprotein association of Hh. Progress in the field of intracellular sterol trafficking has emphasized how tightly the distribution of ...
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GDC-0449 - Targeting the Hedgehog Signaling Pathway

2009
Hedgehog signaling is activated in a variety of solid tumors and hematologic malignancies by point mutations in hedgehog pathway members or autocrine or paracrine ligand secretion. Several hedgehog inhibitors were developed to block hedgehog pathway activity on the level of the activating receptor, Smoothened (Smo).
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