Results 311 to 320 of about 247,901 (376)

3‐Oxabicyclo[3.1.1]heptane as an Isostere of meta‐Benzene

Angewandte Chemie, Volume 137, Issue 25, June 17, 2025.
3‐Oxabicyclo[3.1.1]heptanes were designed as saturated isosteres of meta‐benzene. Crystallographic analysis revealed that these structures and meta‐benzene have identical geometric properties. Replacement of the central benzene ring in the anticancer drug Sonidegib with 3‐oxabicyclo[3.1.1]heptane provided a patent‐free analogue with a nanomolar potency,
Dmitry Dibchak, Pavel K. Mykhailiuk
wiley   +2 more sources

The oncogene MYBL2 promotes the malignant phenotype and suppresses apoptosis through hedgehog signaling pathway in clear cell renal cell carcinoma. [PDF]

Heliyon
Yang W, Chen H, Ma L, Wei M, Xue X, Li Y, Jin Z, Dong J, Xiao H.   +8 more
europepmc   +1 more source

Fish species lifespan prediction from promoter cytosine‐phosphate‐guanine density

Molecular Ecology Resources, Volume 25, Issue 5, July 2025.
Abstract Lifespan is a key attribute of a species' life cycle and varies extensively among major lineages of animals. In fish, lifespan varies by several orders of magnitude, with reported values ranging from less than 1 year to approximately 400 years.
Alyssa M. Budd, Benjamin Mayne, Oliver Berry, Simon Jarman   +3 more
wiley   +1 more source

The dark sides of the GPCR tree ‐ research progress on understudied GPCRs

British Journal of Pharmacology, Volume 182, Issue 14, Page 3109-3134, July 2025.
Abstract A large portion of the human GPCRome is still in the dark and understudied, consisting even of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion GPCRs, Frizzleds and taste receptors. However, it is undeniable that these GPCRs bring an untapped therapeutic potential that should be explored further.
Magdalena M. Scharf, Laura J. Humphrys, Sandra Berndt, Antonella Di Pizio, Juliane Lehmann, Ines Liebscher, Alessandro Nicoli, Masha Y. Niv, Lior Peri, Hannes Schihada, Gunnar Schulte   +10 more
wiley   +1 more source

Hedgehog signaling pathway: A novel target for cancer therapy: Vismodegib, a promising therapeutic option in treatment of basal cell carcinomas

, 2014
Afroz Abidi
openalex   +2 more sources

G protein‐coupled receptor‐mediated autophagy in health and disease

British Journal of Pharmacology, Volume 182, Issue 14, Page 3151-3162, July 2025.
G protein‐coupled receptors (GPCRs) constitute the largest and most diverse superfamily of mammalian transmembrane proteins. These receptors are involved in a wide range of physiological functions and are targets for more than a third of available drugs in the market. Autophagy is a cellular process involved in degrading damaged proteins and organelles
Devrim Öz‐Arslan, Zeynep Aslıhan Durer, Beki Kan   +2 more
wiley   +1 more source

Effect of resveratrol on proliferation and apoptosis of human pancreatic cancer MIA PaCa-2 cells may involve inhibition of the Hedgehog signaling pathway

, 2014
Yong Qin, Zhenhua Ma, Xiaoyan Dang, Wei Li, Qingyong Ma   +4 more
openalex   +2 more sources

Rab23 regulates Nodal signaling in vertebrate left–right patterning independently of the Hedgehog pathway

, 2014
Kimberly P. Fuller, Joyce T. O’Connell, Julie Gordon, Olivier Mauti, Jonathan Eggenschwiler   +4 more
openalex   +1 more source

Effect of Substance P on type II alveolar epithelial cells exposed to hyperoxia and its regulation of the Sonic hedgehog signaling pathway

, 2014
Cong Liu, Lin Yang, Hongxing Dang, Fang Fang, Feng Xu   +4 more
openalex   +2 more sources

Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications

Advanced Science, Volume 12, Issue 21, June 5, 2025.
HDAC6 regulates primary cilia, crucial for cellular signalling and environmental responses. Dysregulation of HDAC6 contributes to ciliopathies, affecting multiple organs. This review examines HDAC6's role in ciliogenesis, its interaction with signaling molecules, and its potential as a therapeutic target.
Zhiyi Wang, Xiaofan Zhu, Zhenzhou Huang, Kaidi Ren, Jie Ran, Yang Yang   +5 more
wiley   +1 more source