Results 321 to 330 of about 834,809 (383)

Sonic Hedgehog signaling pathway in primary liver cancer cells

, 2014
Lianyi Guo, Pei Liu, Ying Wen, Wei Cui, Ying Zhou   +4 more
openalex   +1 more source

GPCR‐G protein signalling and its mutational landscape in cancer—Driver or passenger

British Journal of Pharmacology, Volume 182, Issue 17, Page 3975-3989, September 2025.
G protein‐coupled receptors (GPCRs) play a crucial role in cellular signalling, regulating various physiological processes. Abnormal expression and mutations of GPCRs have been implicated in several types of cancer, influencing tumour initiation, progression and immune response.
Chenlin Feng, Jasper F. Ooms, Erik H. J. Danen, Laura H. Heitman   +3 more
wiley   +1 more source

Effect of resveratrol on proliferation and apoptosis of human pancreatic cancer MIA PaCa-2 cells may involve inhibition of the Hedgehog signaling pathway

, 2014
Yong Qin, Zhenhua Ma, Xiaoyan Dang, Wei Li, Qingyong Ma   +4 more
openalex   +2 more sources

Treatment‐Free Remission in Chronic Myeloid Leukemia: Revisiting the “W” Questions

European Journal of Haematology, Volume 115, Issue 3, Page 218-231, September 2025.
ABSTRACT Chronic myeloid leukemia (CML) has undergone a transformation from a fatal disease to a chronic, manageable condition with the advent of tyrosine kinase inhibitors (TKIs), particularly imatinib. This shift has significantly improved survival rates, and for some patients, achieving deep molecular response (DMR) has made treatment‐free remission
Antonella Bruzzese, Ernesto Vigna, Enrica Antonia Martino, Nicola Amodio, Caterina Labanca, Francesco Mendicino, Eugenio Lucia, Virginia Olivito, Fortunato Morabito, Massimo Gentile   +9 more
wiley   +1 more source

A review of the equine suspensory ligament: Injury prone yet understudied

Equine Veterinary Journal, Volume 57, Issue 5, Page 1167-1182, September 2025.
Abstract The suspensory ligament (SL) is a key component of the elaborate and highly adapted suspensory apparatus in the horse. In addition to contributing to stabilisation of the metacarpophalangeal joint, the SL has a spring like function to reduce the energetic cost of locomotion.
Deborah J. Guest, Helen L. Birch, Chavaunne T. Thorpe   +2 more
wiley   +1 more source

Paralog‐Dependent Specialization of Paf1C Subunit, Ctr9, for Sex Chromosome Gene Regulation and Male Germline Differentiation in Drosophila

Genes to Cells, Volume 30, Issue 5, September 2025.
We show that Drosophila melanogaster genome maintains testis‐specific paralogs encoding components of the transcription regulator Paf1C. One of the paralog products, Ctr9t, forms a unique compartment within the spermatocyte nucleolus. Ctr9t acts as a suppressor of X chromosome genes and an activator of Y chromosome fertility genes, thereby ensuring ...
Toshie Kai, Jinglan Zheng, Taichiro Iki
wiley   +1 more source

Mechanistic insights into dental stem cells‐derived exosomes in regenerative endodontics

International Endodontic Journal, Volume 58, Issue 9, Page 1384-1407, September 2025.
Abstract Background Dental pulp is a richly vascularised and innervated tissue vital for tooth vitality, sensory function, and structural integrity. While conventional root canal therapy effectively treats necrotic permanent teeth, it irreversibly eliminates pulp vitality, potentially increasing the risk of secondary infections and long‐term structural
Paras Ahmad, Nathan Estrin, Nima Farshidfar, Yufeng Zhang, Richard J. Miron   +4 more
wiley   +1 more source

Single‐Step Genome‐Wide Association Study of Factors for Evaluated and Linearly Scored Traits in Swedish Warmblood Horses

Journal of Animal Breeding and Genetics, Volume 142, Issue 5, Page 499-512, September 2025.
ABSTRACT Swedish Warmblood horses (SWB) are bred for show jumping and/or dressage with young horse test scores as indicator traits. This study aimed to investigate possible candidate genes and regions of importance for evaluated and linearly scored young horse test traits.
Anahit Nazari‐Ghadikolaei, W. Freddy Fikse, Åsa Gelinder Viklund, Sofia Mikko, Susanne Eriksson   +4 more
wiley   +1 more source

The Vertebral Column of Flatfish: A Review

Reviews in Aquaculture, Volume 17, Issue 4, September 2025.
ABSTRACT Flatfish (Pleuronectiformes) encompass fascinating fish species known for their high gastronomical value, rearing performances, and market prices, which attract both economic and scientific interest. Despite these attributes, flatfish exhibit unique morphological, developmental, and biological features, as well as distinctive swimming ...
A. M. de Azevedo, A. P. Losada, S. Vázquez, P. E. Witten, M. I. Quiroga, P. J. Gavaia   +5 more
wiley   +1 more source

Prostaglandin E2 and Progesterone Receptor Coordinately Regulate Primary Cilia for Proper Decidualization

The FASEB Journal, Volume 39, Issue 15, 15 August 2025.
Prostaglandin E2 (PGE2) activates the PKA‐CREB1 pathway to promote primary ciliogenesis and upregulates progesterone receptor (PGR) expression in endometrial stromal cells. Progesterone binds to PGR, enhancing the elongation of primary cilia. These processes drive the differentiation of stromal cells into decidual stromal cells, initiating and ...
Chih‐Jhen Lee, Yung‐Chieh Tsai, Ting‐Yu Chen, Yu‐Ying Chao, Ruei‐Ci Lin, Hui‐Ling Tsai, Jen‐Yu Wen, Tang K. Tang, Pei‐Yin Tsai, Pao‐Lin Kuo, Chia‐Yih Wang   +10 more
wiley   +1 more source