Results 331 to 340 of about 834,809 (383)

Advances in Microfluidic Cochlea‐On‐A‐Chip

Advanced Science, Volume 12, Issue 29, August 7, 2025.
This review systematically examines diverse cell sources for inner ear organoids and outlines stepwise induction protocols. Furthermore, it discusses current applications and prospective developments of cochlea‐on‐a‐chip technologies in areas such as deafness modeling, mechanistic studies, and drug evaluation, with particular focus on gene‐therapy drug
Tian Shen, Shanying Han, Weiwei He, Wen Yang, Xinghua Tang, Xiaolong Zhao, Xinghong Liu, Zhenhua Shao, Lin Cheng, Yu Zhao, Jiangang Fan   +10 more
wiley   +1 more source

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, Volume 12, Issue 29, August 7, 2025.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source

Decoding regulatory programs underlying placode and dermal condensate cell fate commitment during hair follicle induction via single‐cell multi‐omics analysis

Animal Research and One Health, Volume 3, Issue 3, Page 297-315, August 2025.
The experimental framework of the study encompasses sample collection, single‐cell data analysis, and experimental validation. Abstract Understanding differences in chromatin state and changes in gene regulatory landscape of placode (Pc) and dermal condensate are crucial for decoding hair follicle (HF) morphogenesis programs.
Fang Li, Minghao Li, Tongtong Zhang, Menghua Sui, Hasan Khatib, Xin Wang   +5 more
wiley   +1 more source

CXCL16 Producing Tumor Clones Are Shaping Immunosuppressive Microenvironment in Squamous Cell Carcinoma via CXCR6 Regulatory T Cell

Cancer Medicine, Volume 14, Issue 15, August 2025.
SCC shapes an immunosuppressive TME via CXCL16/CXCR6 axis. ABSTRACT Background Cutaneous squamous cell carcinoma (cSCC) and basal cell carcinoma (BCC) are the most prevalent types of nonmelanoma skin cancer (NMSC) and exhibit significant inter‐ and intra‐tumor heterogeneity. cSCC has a higher metastatic potential than BCC, accompanied by a considerable
Hyun Seung Choi, Sunyoung Jung, Ki‐Myo Kim, Mihyun Lee, Jun Ho Park, Sanha Hwang, Seung Min Cha, Jade N. Young, Dina Poplausky, Hyunsung Nam, Nicholas Gulati, Chung‐Gyu Park, Hyun Je Kim, Ji‐Ung Park   +13 more
wiley   +1 more source

Development of a Mitochondrial Permeability Transition‐Driven Necrosis‐Related Prognostic Signature in Cervical Cancer: Integrating Bulk Transcriptomic and Single‐Cell Data

Cancer Medicine, Volume 14, Issue 15, August 2025.
ABSTRACT Background Cervical cancer (CC) is a prevalent gynecological malignancy with notable heterogeneity. The role of mitochondrial permeability transition (MPT)‐driven necrosis, a form of cell death due to mitochondrial dysfunction, in CC progression and prognosis is poorly understood and represents a promising therapeutic target for cancers.
Jiaojiao Niu, Sreenivasan Sasidharan
wiley   +1 more source

BMP4 regulates asymmetric Pkd2 distribution in mouse nodal immotile cilia and ciliary mechanosensing required for left–right determination

Developmental Dynamics, Volume 254, Issue 8, Page 965-978, August 2025.
Abstract Background Mouse nodal immotile cilia mechanically sense the bending direction for left–right (L–R) determination and activate the left‐side‐specific signaling cascade, leading to increased Nodal activity. Asymmetric distribution of Pkd2, a crucial channel for L–R determination, on immotile cilia has been reported recently. However, the causal
Takanobu A. Katoh, Tim Lange, Yoshiro Nakajima, Kenta Yashiro, Yasushi Okada, Hiroshi Hamada   +5 more
wiley   +1 more source

Hedgehog Signaling Pathway [PDF]

Science's STKE, 2007
The Hedgehog (Hh) signaling pathway is essential for development and tissue homeostasis in metazoans. Probably as a result of its potent influence on cell-fate outcomes, the Hh pathway when corrupted results in malformations and diseases such as cancer. Many of the pathway components that contribute to Hh-mediated signal transduction are presented.
Lawrence G. Lum, Leni S. Jacob
openaire   +2 more sources

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Overexpression of microRNA‐186 inhibits angiogenesis in retinoblastoma via the Hedgehog signaling pathway by targeting ATAD2

Journal of Cellular Physiology, 2019
Retinoblastoma (RB) represents an aggressive malignancy in the eye during the period of infancy and childhood. We delineated the ability of microRNA‐186 (miR‐186) to influence viability, invasion, migration, angiogenesis, and apoptosis of RB via the ...
Shuai Wu, Mei Han, Chao Zhang
semanticscholar   +1 more source

The Hedgehog Signaling Pathway in Cancer

2005
The Hedgehog (Hh) signaling pathway plays crucial roles during embryonic development, where it controls cell proliferation, differentiation, and tissue patterning in numerous tissues and organs (Ingham and McMahon 2001; Cohen 2003). Mutations in genes encoding key members of the pathway can result in many human developmental disorders, including ...
Janni Vestergaard, Mads Bak, Lars Allan Larsen   +2 more
openaire   +3 more sources