Results 331 to 340 of about 247,901 (376)
Small Science, Volume 5, Issue 6, June 2025.Both native and engineered extracellular vesicles (EVs) are served as promising therapeutic agents for treating acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). To circumvent the limitations of native EVs, various engineering strategies are adopted.
Zhengyan Gu +12 more
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A recurrent mosaic mutation in SMO, encoding the hedgehog signal transducer smoothened, is the major cause of Curry-Jones syndrome [PDF]
, 2016 et al,, Grange, Dorothy K
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FASEB BioAdvances, Volume 7, Issue 6, June 2025.NPC1L1 Inhibits Osteogenesis via the C/EBPα/Cyp27a1/27‐OHC Axis in Osteoporosis Mechanism: ○NPC1L1 expression decreases during osteogenic differentiation. ○NPC1L1 knockdown enhances osteoblast differentiation, proliferation, and migration. ○NPC1L1 promotes cholesterol metabolism (independent of transport function), elevating Cyp27a1‐dependent 27 ...
Bohao Li +9 more
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Healthy Aging Metabolomic and Proteomic Signatures Across Multiple Physiological Compartments
Aging Cell, Volume 24, Issue 6, June 2025.The association of the aging scores with the clinical covariates suggests increased inflammation, strong predisposition to iron deficiency anemia, decline in muscle mass, and renal and hepatic functions with accelerated aging. ABSTRACT The study of biomarkers in biofluids and tissues expanded our understanding of the biological processes that drive ...
R. Moaddel +17 more
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Molecular Oncology, Volume 19, Issue S1, Page 1-895, June 2025.Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
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Clinical and Translational Discovery, Volume 5, Issue 3, June 2025.
Samuel Chauvin +2 more
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Hedgehog Signaling Pathway [PDF]
Science's STKE, 2007 The Hedgehog (Hh) signaling pathway is essential for development and tissue homeostasis in metazoans. Probably as a result of its potent influence on cell-fate outcomes, the Hh pathway when corrupted results in malformations and diseases such as cancer. Many of the pathway components that contribute to Hh-mediated signal transduction are presented.
Lawrence G. Lum, Leni S. Jacob
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The Hedgehog Signaling Pathway in Cancer
2005The Hedgehog (Hh) signaling pathway plays crucial roles during embryonic development, where it controls cell proliferation, differentiation, and tissue patterning in numerous tissues and organs (Ingham and McMahon 2001; Cohen 2003). Mutations in genes encoding key members of the pathway can result in many human developmental disorders, including ...
Janni Vestergaard +2 more
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