Results 341 to 350 of about 834,809 (383)

Aerobic, Metal-Free, and Catalytic Dehydrogenative Coupling of Heterocycles: En Route to Hedgehog Signaling Pathway Inhibitors.

Organic Letters, 2018
The nitrosonium ion-catalyzed dehydrogenative coupling of heteroarenes under mild reaction conditions is reported. The developed method utilizes ambient molecular oxygen as a terminal oxidant, and only water is produced as byproduct.
Luis Bering, Felix M Paulussen, A. Antonchick   +2 more
semanticscholar   +1 more source

Hedgehog Signaling Pathway in Drosophila

Science's STKE, 2007
Studies in Drosophila have provided the framework for understanding human development and disease processes governed by the Hedgehog (Hh) family of secreted signaling molecules. The Drosophila proteins that participate in Hh-mediated signal transduction are highlighted in a Connections Map ...
Lawrence G. Lum, Leni S. Jacob
openaire   +2 more sources

The Hedgehog signalling pathway and cancer

The Journal of Pathology, 2001
The Hedgehog signalling pathway is important in embryological development and is highly conserved through evolution. Recently Patched, a member of the pathway, was found to be important in Gorlin's syndrome. Inherited Patched gene mutations underlie the syndrome, in which a key feature is multiple basal cell carcinomas (BCCs).
openaire   +3 more sources

Potent Inhibitors of the Hedgehog Signaling Pathway

Journal of Medicinal Chemistry, 2008
A small family of phenyl quinazolinone ureas is reported as potent modulators of Hedgehog protein function. Preliminary SAR studies of the urea substituent led to a nanomolar Hedgehog antagonist.
Lee L. Rubin, Edward Andrew Boyd, John H. A. Stibbard, L. I. Kruse, Shirley A. Brunton, Oivin M. Guicherit, Steven Price   +6 more
openaire   +3 more sources

Hedgehog signaling pathway in neuroblastoma differentiation

Journal of Pediatric Surgery, 2010
The hedgehog (Hh) signaling pathway is activated in some adult cancers. On the other hand, the Hh signaling pathway plays an important role in the development of the neural crest in embryos. The aim of this study is to show the activation of Hh signaling pathway in neuroblastoma (NB), a pediatric malignancy arising from neural crest cells, and to ...
Sakura Tanaka, Mitsuo Katano, Tatsuro Tajiri, Tomoaki Taguchi, Kenichi Kohashi, Yoshiaki Kinoshita, Ryota Souzaki, Masae Souzaki, Yoshinao Oda   +8 more
openaire   +3 more sources

The Hedgehog and Wnt signalling pathways in cancer

Nature, 2001
The Wnt and Hedgehog (Hh) signalling pathways have long been known to direct growth and patterning during embryonic development. Recent evidence also implicates these pathways in the postembryonic regulation of stem-cell number in epithelia such as those of the skin and intestine, which undergo constant renewal.
Jussi Taipale, Philip A. Beachy
openaire   +2 more sources

Potent agonists of the Hedgehog signaling pathway

Bioorganic & Medicinal Chemistry Letters, 2009
A family of biaryl substituted 1,4-diaminocyclohexanamides of 3-chlorobenzothiophene-2-carboxylic acid is reported as picomolar modulators of Hedgehog protein function. SAR for the 1,4-diaminocyclohexane group is shown to be exquisitely sensitive to substitution on the 4-amino group, and SAR for the 3-chlorobenzothiophene group is highly specific ...
Stephen Price, Danielle Buxton, Lee L. Rubin, Edward Andrew Boyd, Alaric Avery, Shirley A. Brunton, Oivin M. Guicherit, John H. A. Stibbard, Raffaella Di Lucrezia, L. I. Kruse, Colin H. MacKinnon, Yvonne Park   +11 more
openaire   +3 more sources

The Organocatalytic Approach to Enantiopure 2H- and 3H-Pyrroles: Inhibitors of the Hedgehog Signaling Pathway.

Angewandte Chemie, 2016
A divergent approach to enantioenriched 2H- and 3H-pyrroles catalyzed by a spirocyclic phosphoric acid is reported that makes use of a Fischer-type indolization and a [1,5]-alkyl shift.
Lisa Kötzner, M. Leutzsch, S. Sievers, S. Patil, H. Waldmann, Yiying Zheng, W. Thiel, B. List   +7 more
semanticscholar   +1 more source

Hedgehog signaling pathway in neural development and disease

Psychoneuroendocrinology, 2007
A number of developmental cues underlie proper brain morphogenesis and plasticity. Hedgehog (Hh) signaling pathway plays a critical role in determining proper embryonic patterning and cell fate determination in the central nervous system. Embryonic and adult neural progenitor cells are mostly responsive to Hh signaling, thereby sustaining developmental
Alberto Gulino, Alberto Gulino, Isabella Screpanti, Isabella Screpanti, Enrico De Smaele, Elisabetta Ferretti, Lucia Di Marcotullio   +6 more
openaire   +4 more sources

Pathways and consequences: Hedgehog signaling in human disease

Trends in Cell Biology, 2002
Signaling pathways that play a fundamental role during development are turning out to underlie many disease states when misregulated. Here, we review some of the recent findings in the Hedgehog (Hh) pathway and the role it plays in different human diseases.
Mullor, José L, Sánchez, Pilar, Ruiz Altaba, Ariel   +2 more
openaire   +4 more sources