Results 351 to 360 of about 834,809 (383)

Oxidative regioselective amination of chromones exposes potent inhibitors of the hedgehog signaling pathway.

Chemical Communications, 2015
A transition metal-free, oxidative, regioselective cross-coupling between non-functionalized azoles and chromones at C2-position was developed. A broad reaction scope and further transformation of products were demonstrated.
R. Samanta, Rishikesh Narayan, J. O. Bauer, C. Strohmann, S. Sievers, A. Antonchick   +5 more
semanticscholar   +1 more source

Overview of Hedgehog Signaling Pathway

2011
Initially discovered in Drosophila and later found in all vertebrate model organisms, the Hedgehog (Hh) family of secreted proteins plays critical roles in both embryonic development and adult tissue homeostasis [41, 84]. Numerous human genetic disorders and cancer have been associated with aberrant Hh signaling activity [41, 63, 84].
Chi-chung Hui, Chi-chung Hui, Jin Jiang
openaire   +2 more sources

The Hedgehog signalling pathways in human pathology

Current Diagnostic Pathology, 2004
Abstract Rapid progress in developmental biology over the past 10 years has allowed characterization of many of the fundamental pathways that control growth and differentiation. Much of this information has been derived from studies in fruit flies and zebra fish, which has meant that the terminology has been largely impenetrable to histopathologists ...
Jonathan Bury, Simon S. Cross
openaire   +2 more sources

Wnt and Hedgehog Signaling Pathways in Bone Development

Journal of Bone and Joint Surgery, 2008
Cell-cell signaling is a major strategy that vertebrate embryos employ to coordinately control cell proliferation, differentiation, and survival in many developmental processes. Similar cell signaling pathways also control adult tissue regeneration and repair.
Yingzi Yang, Timothy F. Day
openaire   +3 more sources

Intricacies of hedgehog signaling pathways: A perspective in tumorigenesis

Experimental Cell Research, 2012
The hedgehog (HH) signaling pathway is a crucial negotiator of developmental proceedings in the embryo governing a diverse array of processes including cell proliferation, differentiation, and tissue patterning. The overall activity of the pathway is significantly curtailed after embryogenesis as well as in adults, yet it retains many of its functional
Sujit K. Bhutia, Dipta Sengupta, Samir Kumar Patra, Swayamsiddha Kar, Arunima Shilpi, Moonmoon Deb   +5 more
openaire   +3 more sources

Strategies to target the Hedgehog signaling pathway for cancer therapy

Medicinal research reviews (Print), 2018
Minhang Xin, Xinyue Ji, L. K. C. De La Cruz, Suresh Thareja, B. Wang   +4 more
semanticscholar   +1 more source

Similarities between the Hedgehog and Wnt signaling pathways

Trends in Cell Biology, 2002
Hedgehog and Wnt proteins are signaling molecules that direct many aspects of metazoan development through signal transduction pathways that are just beginning to be understood. Recently, the common use of glycogen synthase kinase 3 and casein kinase 1 has been added to a growing list of straightforward similarities between Hedgehog and Wnt signaling ...
openaire   +3 more sources

Hedgehog signaling pathway: Epigenetic regulation and role in disease and cancer development

Journal of Cellular Physiology, 2018
S. Fattahi, Maryam Pilehchian Langroudi, H. Akhavan‐Niaki   +2 more
semanticscholar   +1 more source

GDC-0449 - Targeting the Hedgehog Signaling Pathway

2009
Hedgehog signaling is activated in a variety of solid tumors and hematologic malignancies by point mutations in hedgehog pathway members or autocrine or paracrine ligand secretion. Several hedgehog inhibitors were developed to block hedgehog pathway activity on the level of the activating receptor, Smoothened (Smo).
openaire   +3 more sources

Cellular and molecular mechanisms of Hedgehog signalling

Nature Reviews Molecular Cell Biology, 2023
Yunxiao Zhang, Philip A Beachy
exaly