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Wnt and Hedgehog Signaling Pathways in Bone Development
Journal of Bone and Joint Surgery, 2008Cell-cell signaling is a major strategy that vertebrate embryos employ to coordinately control cell proliferation, differentiation, and survival in many developmental processes. Similar cell signaling pathways also control adult tissue regeneration and repair.
Yingzi Yang, Timothy F. Day
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Intricacies of hedgehog signaling pathways: A perspective in tumorigenesis
Experimental Cell Research, 2012The hedgehog (HH) signaling pathway is a crucial negotiator of developmental proceedings in the embryo governing a diverse array of processes including cell proliferation, differentiation, and tissue patterning. The overall activity of the pathway is significantly curtailed after embryogenesis as well as in adults, yet it retains many of its functional
Sujit K. Bhutia +5 more
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Similarities between the Hedgehog and Wnt signaling pathways
Trends in Cell Biology, 2002Hedgehog and Wnt proteins are signaling molecules that direct many aspects of metazoan development through signal transduction pathways that are just beginning to be understood. Recently, the common use of glycogen synthase kinase 3 and casein kinase 1 has been added to a growing list of straightforward similarities between Hedgehog and Wnt signaling ...
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GDC-0449 - Targeting the Hedgehog Signaling Pathway
2009Hedgehog signaling is activated in a variety of solid tumors and hematologic malignancies by point mutations in hedgehog pathway members or autocrine or paracrine ligand secretion. Several hedgehog inhibitors were developed to block hedgehog pathway activity on the level of the activating receptor, Smoothened (Smo).
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Cellular and molecular mechanisms of Hedgehog signalling
Nature Reviews Molecular Cell Biology, 2023Yunxiao Zhang, Philip A Beachy
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Apatite‐Binding Nanoparticulate Agonist of Hedgehog Signaling for Bone Repair
Advanced Functional Materials, 2020Chung-sung Lee, Xiao Zhang, Jiabing Fan
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Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
Nature, 2003Marina Pasca Di Magliano +2 more
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Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
Nature, 2009Hyog Young Kwon, Tannishtha Reya
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Hedgehog signalling in the mouse requires intraflagellar transport proteins
Nature, 2003Danwei Huangfu, Aimin Liu, Lee Niswander
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