Meningioma cells express primary cilia but do not transduce ciliary Hedgehog signals
Acta Neuropathologica Communications, 2020 Meningiomas are the most common primary intracranial tumors, but treatment options for meningioma patients are limited due to incomplete understanding of tumor biology.
Sarah Findakly +5 more
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Context-dependent ciliary regulation of hedgehog pathway repression in tissue morphogenesis.
PLoS Genetics, 2023 A fundamental problem in tissue morphogenesis is identifying how subcellular signaling regulates mesoscale organization of tissues. The primary cilium is a paradigmatic organelle for compartmentalized subcellular signaling.
Sun-Hee Hwang +4 more
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Palatogenesis: The role of Sonic hedgehog (Shh) signaling in the secondary palate development
Sakarya Tıp Dergisi, 2022 Palatogenesis is a complicated and precisely balanced process in which malfunctions induce congenital cleft palate, one of the most common embryonic developmental anomaly seen in newborns.
Elvan Şahin, Reem Al-towaitee
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β-arrestin1-mediated acetylation of Gli1 regulates Hedgehog/Gli signaling and modulates self-renewal of SHH medulloblastoma cancer stem cells [PDF]
, 2017 Background Aberrant Sonic Hedgehog/Gli (Hh/Gli) signaling pathway is a critical regulator of Sonic hedgehog medulloblastoma (SHH-MB). Cancer stem cells (CSCs), thought to be largely responsible for tumor initiation, maintenance, dissemination and ...
Abballe, Luana +17 more
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The Many Hats of Sonic Hedgehog Signaling in Nervous System Development and Disease. [PDF]
, 2016 Sonic hedgehog (Shh) signaling occurs concurrently with the many processes that constitute nervous system development. Although Shh is mostly known for its proliferative and morphogenic action through its effects on neural stem cells and progenitors, it ...
Belgacem, Yesser H +4 more
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Hedgehog Signaling and Embryonic Craniofacial Disorders
Journal of Developmental Biology, 2019 Since its initial discovery in a Drosophila mutagenesis screen, the Hedgehog pathway has been revealed to be instrumental in the proper development of the vertebrate face. Vertebrates possess three hedgehog paralogs: Sonic hedgehog (Shh), Indian hedgehog
John Abramyan
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Atrioventricular canal defect and genetic syndromes: the unifying role of sonic hedgehog [PDF]
, 2019 The atrioventricular canal defect (AVCD) is a congenital heart defect (CHD) frequently associated with extracardiac anomalies (75%). Previous observations from a personal series of patients with AVCD and "polydactyly syndromes" showed that the distinct ...
Baban, A +9 more
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Shifted from Wnt to Hedgehog Signaling Pathways [PDF]
Molecular Cell, 2005 Two papers in recent issue of Developmental Cell (Glise et al. 2005; Gorfinkiel et al. 2005) have shown that Shifted, a Drosophila ortholog of Wnt Inhibitory Factor (WIF), modulates the distribution of Hedgehog protein in the wing imaginal disc through a Wnt-independent mechanism.
Xinhua Lin, Chun Han
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Recent Advances in the Clinical Targeting of Hedgehog/GLI Signaling in Cancer
Cells, 2019 The Hedgehog/GLI signaling pathway plays an important role in normal embryonic tissue development and has been implicated in the pathogenesis of various human cancers.
Hao Xie +3 more
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Ethanol Effects on Early Developmental Stages Studied Using the Zebrafish
Biomedicines, 2022 Fetal alcohol spectrum disorder (FASD) results from prenatal ethanol exposure. The zebrafish (Danio rerio) is an outstanding in vivo FASD model. Early development produced the three germ layers and embryonic axes patterning.
Priyadharshini Manikandan +2 more
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