Results 41 to 50 of about 21,316 (283)
Hedgehog Bases for A_n Cluster Polylogarithms and An Application to Six-Point Amplitudes
, 2015 Multi-loop scattering amplitudes in N=4 Yang-Mills theory possess cluster algebra structure. In order to develop a computational framework which exploits this connection, we show how to construct bases of Goncharov polylogarithm functions, at any weight,
Parker, Daniel E. +3 more
core +1 more source
Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling [PDF]
Nature Chemical Biology, 2013 Inhibition of Sonic hedgehog (Shh) signaling is of great clinical interest. Here we exploit Hedgehog acyltransferase (Hhat)-mediated Shh palmitoylation, a modification critical for Shh signaling, as a new target for Shh pathway inhibition. A target-oriented high-throughput screen was used to identify small-molecule inhibitors of Hhat.
Petrova, Elissaveta +4 more
openaire +2 more sources
Majorana Fermions and Non-Abelian Statistics in Three Dimensions
, 2010 We show that three dimensional superconductors, described within a Bogoliubov de Gennes framework can have zero energy bound states associated with pointlike topological defects. The Majorana fermions associated with these modes have non-Abelian exchange
C. L. Kane +3 more
core +1 more source
Beneficial Land Management for Hedgehogs (Erinaceus europaeus) in the United Kingdom
Animals, 2020 Hedgehogs (Erinaceus europaeus) are traditionally thought of as being a rural dwelling species, associated with rural and agricultural landscapes across Europe.
Richard W. Yarnell, Carly E. Pettett
doaj +1 more source
Universal Sets for Straight-Line Embeddings of Bicolored Graphs
, 2011 A set S of n points is 2-color universal for a graph G on n vertices if for every proper 2-coloring of G and for every 2-coloring of S with the same sizes of color classes as G has, G is straight-line embeddable on S.
Cibulka, Josef +4 more
core +1 more source
Nucleon-Nucleon Scattering and Large N(c) QCD [PDF]
, 2013 Nucleon-nucleon scattering observables are discussed in the context of large Nc QCD. As is well known, the baryon spectrum in the large Nc limit exhibits contracted SU(2Nf) spin-flavor sym- metry.
Gelman, Boris A.
core +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Hedgehogs in Contact with Humans: Zoonotic and Reverse Zoonotic Transmission of Pathogens
Journal of Zoological and Botanical GardensNumerous previous studies indicate that both wild hedgehogs and those kept as pets pose a significant risk to human health. At the same time, humans can also transmit various pathogens to hedgehogs (e.g., human herpesvirus 1). The risk of human infection
Dražen Đuričić, Maja Lukač
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source