Results 241 to 250 of about 4,870,076 (306)

Boronic Acid Inhibitors of β‐Lactamases: A Promising Strategy Against Antimicrobial Resistance

Medicinal Research Reviews, EarlyView.
ABSTRACT The rise of antimicrobial resistance (AMR) poses a critical threat to global health, mostly due to the proliferation of β‐lactamases, a class of enzymes responsible for the inactivation of β‐lactam antibiotics. Among the most promising strategies to restore β‐lactam efficacy is the use of β‐lactamase inhibitors (BLIs), with boronic acid ...
Nicolò Santi, Federico Corsini, Robert A. Bonomo, Emilia Caselli, Fabio Prati   +4 more
wiley   +1 more source

Calcium oscillations in HEK293 cells lacking SOCE suggest the existence of a balanced regulation of IP₃ production and degradation. [PDF]

Front Syst Biol
Octors C, Yoast RE, Emrich SM, Trebak M, Sneyd J.   +4 more
europepmc   +1 more source

Cationic‐Hydrophilic Di‐Block Copolymers: Surface‐Shielded Vectors for Gene Delivery

Journal of Polymer Science, Volume 63, Issue 6, Page 1419-1432, 15 March 2025.
This study develops synthetic polycationic di‐block carriers for nucleic acid (NA) delivery in gene therapy. Consisting of a cationic block and a hydrophilic block, these carriers efficiently form complexes with NAs and shield them with a protective bioinert layer, enhancing stability during circulation in the bloodstream while reducing undesirable ...
Eliška Hrdá, Ladislav Androvič, Marcela Filipová, Michal Pechar, Richard Laga   +4 more
wiley   +1 more source

Ruta graveolens L. in Evidence‐Based Phytotherapy: Pharmacological Activities, Bioactive Compounds and Safety

Phytotherapy Research, EarlyView.
Graphical representation of ethnomedical uses, major bioactive compounds, pharmacological potential and toxicological risks of Ruta graveolens L. ABSTRACT Ruta graveolens L. is widely used in traditional European, Asian, African, and South American medicine for digestive, nervous, cardiovascular, respiratory, and reproductive disorders.
Tetiana Serhiienko, Victoriya Georgiyants, Liudas Ivanauskas, Olha Mykhailenko   +3 more
wiley   +1 more source

Tris(1,3-dichloro-2-propyl) phosphate disrupts cellular metabolism within human embryonic kidney (HEK293) cells. [PDF]

J Hazard Mater
Avila-Barnard S, Ha M, Nemarugommula C, Wiegand JL, Ke H, De Souza A, Behar R, Volz DC.   +7 more
europepmc   +1 more source

Rapid and Efficient Affinity Isolation of Engineered Extracellular Vesicles Encapsulating Functional Proteins via Internal Twin‐Strep Tetraspanin Tagging

Small, EarlyView.
Structure‐guided internal twin‐Strep tagging of the tetraspanins CD63 or CD9 enables rapid and efficient antibody‐free affinity isolation of engineered extracellular vesicles (EVs) using Strep technology while allowing luminal protein loading. The approach removes over 96% of contaminants, separates tagged EVs from coexisting viral particles, and ...
Minh‐Tu Pham, Jona Benjamin Krohn, Janis Meyer, Christian Ritter, Martin Schneider, Dominic Helm, Dario Frey, Kleopatra Rapti, Uta Haselmann‐Weiss, Elif Toprak, Viet Loan Dao Thi, Florian Leuschner, Dirk Grimm, Karl Rohr, Ralf Bartenschlager   +14 more
wiley   +1 more source

Systematic comparison of rAAV vectors manufactured using large-scale suspension cultures of Sf9 and HEK293 cells. [PDF]

Mol Ther
Liu S, Li J, Peraramelli S, Luo N, Chen A, Dai M, Liu F, Yu Y, Leib RD, Li Y, Lin K, Huynh D, Li S, Ou L.   +13 more
europepmc   +1 more source

A Serum‐Resistant Plasma Membrane Probe for Real‐Time Visualization of Pathogen‐Induced Epithelial Barrier Dysfunction

Small, EarlyView.
PM580 selectively activates at the plasma membrane while remaining minimally responsive to serum albumin, enabling serum‐compatible, surface‐confined imaging for 24 h, unlike conventional probes that rapidly internalize and lose membrane contrast.
Yujeong Choi, Sunhwa Jung, Dong Min Kang, Lizaveta Gotina, Minji Kim, Eunmi Ha, Sungsu Lim, Ae Nim Pae, Jaeson Jang, Evgeni Ponimaskin, Ja‐Hyun Baik, Sun‐Joon Min, Yun Kyung Kim   +12 more
wiley   +1 more source

Sodium acetate increases the productivity of HEK293 cells expressing the ECD-Her1 protein in batch cultures: experimental results and metabolic flux analysis. [PDF]

Front Bioeng Biotechnol
Pérez-Fernández BA, Calzadilla L, Enrico Bena C, Del Giudice M, Bosia C, Boggiano T, Mulet R.   +6 more
europepmc   +1 more source

A pH‐Responsive fluorescence lifetime probe reveals GOT1 phase separation in cellular anti‐senescence

Smart Molecules, EarlyView.
Acidic pH triggers GOT1 phase separation via IDR1, recruiting ME1 to form ROS‐scavenging condensates that combat senescence, revealed by a FLIM‐based pH probe. Abstract Cellular senescence involves progressive acidification, but how cells sense and adapt to this pH shift remains unclear.
Ziyue Chen, Jiaqi Li, Yan Bao, Mengmeng Wang, Haoyan Chen, Mingjiong Zhang, Lina Ding, Shuangshuang Wu, Baoxing Shen   +8 more
wiley   +1 more source