Results 51 to 60 of about 3,681 (304)

Condensates in rotating turbulent flows

, 2017
Using a large number of numerical simulations we examine the steady state of rotating turbulent flows in triple periodic domains, varying the Rossby number $Ro$ (that measures the inverse rotation rate) and the Reynolds number $Re$ (that measures the ...
Alexakis, Alexandros, Seshasayanan, Kannabiran   +1 more
core   +1 more source

Energy transfer in Hall-MHD turbulence: cascades, backscatter, and dynamo action [PDF]

, 2005
Scale interactions in Hall MHD are studied using both the mean field theory derivation of transport coefficients, and direct numerical simulations in three space dimensions.
Alexakis, ALEXANDROS ALEXAKIS, ANNICK POUQUET, Helmis, Iroshnikov, Krause, Mininni, PABLO D. MININNI, Seehafer, Smith, Steenbeck, Zeldovich   +11 more
core   +3 more sources

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

CHD pile performance, part II:Numerical modelling [PDF]

, 2016
In this paper, a set of simple modelling procedures are presented that can be used to estimate the load-settlement behaviour of Continuous Helical Displacement (CHD) piles in sands, in conjunction with the Finite Element Method (FEM).
Brinkgreve RBJ, Hardin BO, Jamiolkowski M, John Ross Jeffrey, Jonathan Adam Knappett, Jonathan David Ball, Karlis Caucis, Katzenbach R, Knappett JA, Kulhawy FH, Michael John Brown, Santos JA, Schanz T, Wehnert M   +13 more
core   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Helical Piles Embedded in Expansive Soil Overlaying Sandy Soil

Al-Khawarizmi Engineering Journal, 2016
In this study, the behavior of square helical piles models (5×5) mm2 embedded in expansive soil bed overlaying a layer of sandy soil was investigated. The sand layer 200mm thickness was compacted into four sub layers in a steel container with diameter ...
Hassan Obaid Abbase, Bushra Suhail Al-Busoda   +1 more
doaj   +2 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Analysis of a rapid load test on an instrumented bored pile in clay [PDF]

, 2006
Rapid load testing methods for piled foundations are generally easier and quicker to mobilise than classic static tests, and are less complex to analyse than dynamic load tests.
A. F. L. Hyde, Bell A., Berridge N. G., Borghi X., British Standards Institution, Brown M. J., Delpak R., Dunnicliff J., Gibson G. C., Hird C. C., Holeyman A. E., Hyde A. F. L., Institution of Civil Engineers, Kusakabe O., M. J. Brown, Marsland A., McVay M. C., Middendorp P., Middendorp P., Middendorp P., Nishimura S., Powell J. J. M., Randolph M. F., Randolph M. F., Smith E. A. L., Tatsuoka F., Taylor P. T., W. F. Anderson, Weltman A. J.   +28 more
core   +2 more sources