Results 101 to 110 of about 194,742 (384)

Human RPA activates BLM’s bidirectional DNA unwinding from a nick

eLife, 2020
BLM is a multifunctional helicase that plays critical roles in maintaining genome stability. It processes distinct DNA substrates, but not nicked DNA, during many steps in DNA replication and repair. However, how BLM prepares itself for diverse functions
Zhenheng Qin, Lulu Bi, Xi-Miao Hou, Siqi Zhang, Xia Zhang, Ying Lu, Ming Li, Mauro Modesti, Xu-Guang Xi, Bo Sun   +9 more
doaj   +1 more source

Regulation of translocation polarity by helicase domain 1 in SF2B helicases [PDF]

The EMBO Journal, 2011
Structurally similar superfamily I (SF1) and II (SF2) helicases translocate on single-stranded DNA (ssDNA) with defined polarity either in the 5'-3' or in the 3'-5' direction. Both 5'-3' and 3'-5' translocating helicases contain the same motor core comprising two RecA-like folds.
Maria Spies, Robert A. Pugh, Colin Wu
openaire   +3 more sources

Transcriptome‐Wide Association Uncovers LncRNAs Controlling Seed Weight in Soybean

Advanced Science, EarlyView.
This study employs transcriptome‐wide association studies (TWAS) to identify 201 long non‐coding RNAs (lncRNAs) associated with seed weight. Expression quantitative trait locus (eQTL) analysis reveals dynamic and static regulatory variants controlling lncRNA expression across development.
Xiang Wang, Xinyu Jiang, Xiaobo Yuan, Zhipeng Zhou, Zhenwei Zhao, Longfei Wang, Wu Jiao, Wenxue Ye, Qingxin Song   +8 more
wiley   +1 more source

Identification of a novel nuclease activity in human DDX49 helicase

Royal Society Open Science
Human DDX49 is an emerging target in cancer progression and retroviral diseases through its essential roles in nucleolar RNA processing. Here, we identify nuclease activity of human DDX49, which requires active site aspartate residues within a conserved ...
Ashley J. Parkes, Sabesan Anandavijayan, Anna Lou-Hing, Olivia Downs, Tom Killelea, Louise Martin, Fiorela Kapllanaj, Edward L. Bolt   +7 more
doaj   +1 more source

The three-component helicase/primase complex of herpes simplex virus-1

Open Biology, 2021
Herpes simplex virus type 1 (HSV-1) is one of the nine herpesviruses that infect humans. HSV-1 encodes seven proteins to replicate its genome in the hijacked human cell.
Oya Bermek, R. Scott Williams
doaj   +1 more source

Structure of NS3 helicase from Zika virus

Nature Structural &Molecular Biology, 2016
Zika virus has emerged as a pathogen of major health concern. Here, we present a high-resolution (1.62-Å) crystal structure of the RNA helicase from the French Polynesia strain. The structure is similar to that of the RNA helicase from Dengue virus, with
R. Jain, Javier Coloma, A. García-Sastre, A. Aggarwal   +3 more
semanticscholar   +1 more source

Rapid purification of helicase proteins and in vitro analysis of helicase activity [PDF]

Methods, 2010
Most processes involving an organism’s genetic material, including replication, repair and recombination, require access to single stranded DNA as a template or reaction intermediate. To disrupt the hydrogen bonds between the two strands in double stranded DNA, organisms utilize proteins called DNA helicases. DNA helicases use duplex DNA as a substrate
Steven W. Matson, Kambiz Tahmaseb
openaire   +3 more sources

The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis [PDF]

, 2019
Post-transcriptional mechanisms have the potential to influence complex changes in gene expression, yet their role in cell fate transitions remains largely unexplored.
Aigner, S., Anselmo, A., Brumbaugh, J., Charlton, J., Clement, K., Clowers, K., de Kort, M., Di Stefano, B., Gerli, M., Gu, H., Gygi, S., Haggerty, C., Hochedlinger, K., Huebner, A., Ji, F., Lipchina, I., Luo, E., Meissner, A., Pulice, J., Rabano Jiménez, I., Sadreyev, R., Yeo, G.   +21 more
core   +3 more sources

The GGH/HuR Complex Binds and Stabilizes mRNAs to Maintain Tumor Cell Cycle and DNA Replication

Advanced Science, EarlyView.
Despite its canonical role in inhibiting DNA synthesis, GGH promotes tumor growth as a novel RNA‐binding protein. GGH binds GC‐rich 5′UTRs (e.g., CDC6/CCND1), recruits HuR to form a ternary complex that stabilizes mRNA via circular conformation, fueling DNA replication and the cell cycle. Targeting this axis suppresses NSCLC progression.
Yu Li, Xinrui Li, Yuhui Du, Sijie Chen, Xiaoniu He, Zhangrong Xie, Zhiqing Zhou, Huijie Zhao, Xiaofei Zeng, Guoan Chen   +9 more
wiley   +1 more source

Crystal structure of the Ilheus virus helicase: implications for enzyme function and drug design

Cell & Bioscience, 2022
Background The Ilheus virus (ILHV) is an encephalitis associated arthropod-borne flavivirus. It was first identified in Ilheus City in the northeast Brazil before spreading to a wider geographic range.
De-Ping Wang, Mei-Yue Wang, Yong-Mei Li, Wen Shu, Wen Cui, Fang-Ying Jiang, Xin Zhou, Wen-Ming Wang, Ji-Min Cao   +8 more
doaj   +1 more source