Results 131 to 140 of about 215,192 (350)

Intelligent Thermo‐Self‐Limited Magnetothermia with Heat‐Triggered TERT Silencing for Precision Synergetic Cancer Therapy

Advanced Science, EarlyView.
Telomerase reverse transcriptase (TERT) mRNA induces DNA self‐assembly in cancer cells, boosting the nanoplatform's magnetothermal properties. This magnetothermia then activates the Hsp70 promoter, initiating siRNA synthesis to silence the TERT gene, enhancing cancer treatment.
Liang Zhang, Mingfu Gong, Tao Sun, Shilin Xiao, Yue Zhao, Xiaofeng Yang, Wansu Zhang, Chunyu Zhou, Xu Liu, Dong Zhang   +9 more
wiley   +1 more source

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
Regulatory T cells (Tregs) suppress antitumor immunity. This study identifies that the translation scaffold DAP5/eIF4G2 is upregulated in tumor‐infiltrating Tregs (ti‐Tregs). DAP5 mediates an alternate translation mode to sustain CD25 and MCL‐1 expression, which is critical for ti‐Treg stability and survival in the tumor microenvironment.
Xiaojiang Lai, Guihong Pan, Xixi Feng, Jun Zhang, Yunxia Li, Shanmeizi Zhao, Zhenming Lin, Yun Feng, Wei Bao, Hongyan Yang, Chengmei Xie, Chen Huang, Jun Wang   +12 more
wiley   +1 more source

Structure of the eukaryotic replicative CMG helicase and pumpjack motion

Nature Structural &Molecular Biology, 2016
The CMG helicase is composed of Cdc45, Mcm2–7 and GINS. Here we report the structure of the Saccharomyces cerevisiae CMG, determined by cryo-EM at a resolution of 3.7–4.8 Å.
Zuanning Yuan, Lin Bai, Jingchuan Sun, R. Georgescu, Jun Liu, M. O’Donnell, Huilin Li   +6 more
semanticscholar   +1 more source

Flap Endonuclease Disengages Dna2 Helicase/Nuclease from Okazaki Fragment Flaps [PDF]

, 2006
Okazaki fragments contain an initiator RNA/DNA primer that must be removed before the fragments are joined. In eukaryotes, the primer region is raised into a flap by the strand displacement activity of DNA polymerase {delta}.
Bambara, Robert A., Campbell, Judith L., Stewart, Jason A.   +2 more
core   +1 more source

Protein cofactor competition regulates the action of a multifunctional RNA helicase in different pathways

RNA Biology, 2016
A rapidly increasing number of RNA helicases are implicated in several distinct cellular processes, however, the modes of regulation of multifunctional RNA helicases and their recruitment to different target complexes have remained unknown. Here, we show
A. Heininger, Philipp Hackert, Alexandra Z. Andreou, Kum-Loong Boon, Indira Memet, Mira Prior, A. Clancy, Bernhard Schmidt, H. Urlaub, E. Schleiff, K. Sloan, Markus Deckers, R. Lührmann, J. Enderlein, D. Klostermeier, P. Rehling, M. Bohnsack   +16 more
semanticscholar   +1 more source

Rudimentary G-Quadruplex-Based Telomere Capping In Saccharomyces Cerevisiae [PDF]

, 2011
Telomere capping conceals chromosome ends from exonucleases and checkpoints, but the full range of capping mechanisms is not well defined. Telomeres have the potential to form G-quadruplex (G4) DNA, although evidence for telomere G4 DNA function in vivo ...
A De Cian, A Piazza, A Risitano, A Risitano, A Sfeir, AC Vallur, AN Lane, B Garvik, B Saccà, BR Linger, C Frei, C Ribeyre, CI Nugent, D Bonetti, D Gomez, DA Bernstein, David C Schultz, David Monchaud, EA Venczel, EP Mimitou, F Brad Johnson, H Ding, H Fernando, IM Pedroso, J Kypr, J Lin, J Lu, J Ren, J-L Mergny, JA Cobb, Jasmine S Smith, JD Frantz, John M Nicoludis, JR Mullen, JS Smith, K Förstemann, K Paeschke, L Maringele, L Oganesian, Lara Abramowitz, LD Nelson, Liliya A Yatsunyk, LL Sandell, M Downey, Marie-Paule Teulade-Fichou, Mark S Garcia, MD Huber, MD Huber, MD Vodenicharov, MK Zubko, MK Zubko, ML Kozak, ML Zhang, MW Van Dyke, N Grandin, N Hayashi, P Phatak, PM Watt, Qijun Chen, R Giraldo, Ramon Kranaster, RJ Michelson, S Burge, SG Addinall, SG Hershman, Shankar Balasubramanian, TR Salas, W Palm, Y Li, Y-C Tsai, Z Liu, Z Zhu   +71 more
core   +2 more sources

New Insights Into DNA Helicases as Druggable Targets for Cancer Therapy

Frontiers in Molecular Biosciences, 2018
Small molecules that deter the functions of DNA damage response machinery are postulated to be useful for enhancing the DNA damaging effects of chemotherapy or ionizing radiation treatments to combat cancer by impairing the proliferative capacity of ...
Arindam Datta, Robert M. Brosh
doaj   +1 more source

The crystal structure of Zika virus helicase: basis for antiviral drug design

Protein & Cell, 2016
The genus of Flavivirus contains important human pathogens, including dengue (DENV), yellow fever (YFV), West Nile (WNV), Japanese encephalitis (JEV), and tick-borne encephalitis (TBEV) viruses, which cause a number of serious human diseases throughout ...
H. Tian, X. Ji, Xiaoyun Yang, W. Xie, Kailin Yang, Cheng Chen, Chen Wu, H. Chi, Z. Mu, Zefang Wang, Haitao Yang   +10 more
semanticscholar   +1 more source

A two-state model for helicase translocation and unwinding of nucleic acids [PDF]

, 2008
Helicases are molecular motors that unwind double-stranded nucleic acids (dsNA), such as DNA and RNA). Typically a helicase translocates along one of the NA single strands while unwinding and uses adenosine triphosphate (ATP) hydrolysis as an energy ...
Ashok Garai, B. Alberts, C. L. Tai, D. N. Frick, Debashish Chowdhury, J. Howard, M. D. Betterton, N. David   +7 more
core   +2 more sources

Suppressed Protein Translation Caused by MSP‐8 Deficiency Determines Fungal Multidrug Resistance with Fitness Cost

Advanced Science
Antifungal resistance, particularly the rise of multidrug‐resistance strains, poses a significant public health threat. In this study, the study identifies a novel multidrug‐resistance gene, msp‐8, encoding a helicase, through experimental evolution with
Mi Zhou, Pengju Yu, Chengcheng Hu, Wenxia Fang, Cheng Jin, Shaojie Li, Xianyun Sun   +6 more
doaj   +1 more source