Results 131 to 140 of about 191,259 (287)

Dna2 is a structure-specific nuclease, with affinity for 5'-flap intermediates [PDF]

, 2010
Dna2 is a nuclease/helicase with proposed roles in DNA replication, double-strand break repair and telomere maintenance. For each role Dna2 is proposed to process DNA substrates with a 5'-flap.
Aguilera, Ayyagari, Bae, Bae, Bae, Balakrishnan, Bell, Bonetti, Budd, Budd, Budd, Budd, Budd, Budd, Ceska, Chapados, Dervan, Devos, Duxin, Garg, Harrington, Hohl, Hosfield, Jason A. Stewart, Judith L. Campbell, Kao, Kao, Kao, Kim, Kim, Lee, Liao, Liu, Liu, Liu, Masuda-Sasa, Masuda-Sasa, Mathews, Moser, Mueser, Murante, Qiu, Robert A. Bambara, Robertson, Shrader, Stewart, Stewart, Stewart, Szczesny, Weitao, Williams, Xu, Zheng, Zhu, Zuker   +54 more
core   +2 more sources

Human Enterovirus Nonstructural Protein 2CATPase Functions as Both an RNA Helicase and ATP-Independent RNA Chaperone

PLoS Pathogens, 2015
RNA helicases and chaperones are the two major classes of RNA remodeling proteins, which function to remodel RNA structures and/or RNA-protein interactions, and are required for all aspects of RNA metabolism.
Hongjie Xia, Peipei Wang, Guangchuan Wang, Jie Yang, Xianlin Sun, Wenzhe Wu, Y. Qiu, T. Shu, Xiaolu Zhao, Lei Yin, C. Qin, Yuanyang Hu, Xiaoping Zhou, B. Semler   +13 more
semanticscholar   +1 more source

ATPase mechanism of the 5'-3' DNA helicase, RecD2: evidence for a pre-hydrolysis conformation change [PDF]

, 2013
The superfamily 1 helicase, RecD2, is a monomeric, bacterial enzyme with a role in DNA repair, but with 5'-3' activity unlike most enzymes from this superfamily. Rate constants were determined for steps within the ATPase cycle of RecD2 in the presence of
Bae, Bird, Boulé, Brune, Brune, Cao, Chisty, Christopher P. Toseland, Cremo, Dillingham, Gu, Henn, Henn, Hiratsuka, Ivessa, Jameson, Leatherbarrow, Lohman, Manosas, Martin R. Webb, Moore, Nixon, Okoh, Rocha, Saikrishnan, Singleton, Slatter, Soultanas, Toseland, Toseland, Toseland, Toseland, Wang, Webb, Webb   +34 more
core   +1 more source

Insights into the mechanism of a G-quadruplex-unwinding DEAH-box helicase

Nucleic Acids Research, 2015
The unwinding of nucleic acid secondary structures within cells is crucial to maintain genomic integrity and prevent abortive transcription and translation initiation.
Michael C. Chen, Pierre Murat, Keren Abecassis, A. Ferré-D’Amaré, S. Balasubramanian   +4 more
semanticscholar   +1 more source

The ORC/Cdc6/MCM2-7 complex facilitates MCM2-7 dimerization during prereplicative complex formation.

, 2014
The replicative mini-chromosome-maintenance 2-7 (MCM2-7) helicase is loaded in Saccharomyces cerevisiae and other eukaryotes as a head-to-head double-hexamer around origin DNA.
Alberto Riera, Alejandra Fernández-Cid, Bell, Bochman, Bowers, Cecile Evrin, Chen, Christian Speck, Cocker, Coleman, Evrin, Evrin, Fernández-Cid, Fletcher, Fletcher, Francis, Gambus, Ge, Ibarra, Juergen Zech, Liang, M. Carmen Herrera, Moyer, Neuwald, Pippa Clarke, Randell, Randell, Remus, Remus, Rudi Lurz, Sclafani, Seki, Silvia Tognetti, Speck, Speck, Stillman, Sun, Takara, Tanaka, Ying   +39 more
core   +1 more source

Mechanisms of Helicases [PDF]

Journal of Biological Chemistry, 2006
Ilker Donmez, Smita S. Patel
openaire   +3 more sources

A 7-kDa region of the bacteriophage T7 gene 4 protein is required for primase but not for helicase activity. [PDF]

, 1988
J A Bernstein, C C Richardson
openalex   +1 more source

Viral Helicases

, 2009
Helicases are motor proteins that use the free energy of NTP hydrolysis to catalyze the unwinding of duplex nucleic acids. Helicases participate in almost all processes involving nucleic acids. Their action is critical for replication, recombination, repair, transcription, translation, splicing, mRNA editing, chromatin remodeling, transport, and ...
Rajagopal, Vaishnavi, Patel, Smita S.
openaire   +1 more source

Modeling pathogenic mutations of human twinkle in Drosophila suggests an apoptosis role in response to mitochondrial defects.

PLoS ONE, 2012
The human gene C10orf2 encodes the mitochondrial replicative DNA helicase Twinkle, mutations of which are responsible for a significant fraction of cases of autosomal dominant progressive external ophthalmoplegia (adPEO), a human mitochondrial disease ...
Alvaro Sanchez-Martinez, Manuel Calleja, Susana Peralta, Yuichi Matsushima, Rosana Hernandez-Sierra, Alexander J Whitworth, Laurie S Kaguni, Rafael Garesse   +7 more
doaj   +1 more source

Benzothiazole and Pyrrolone Flavivirus Inhibitors Targeting the Viral Helicase.

ACS Infectious Diseases, 2015
The flavivirus nonstructural protein 3 (NS3) is a protease and helicase, and on the basis of its similarity to its homologue encoded by the hepatitis C virus (HCV), the flavivirus NS3 might be a promising drug target.
Noreena L. Sweeney, Alicia M. Hanson, S. Mukherjee, J. Ndjomou, B. Geiss, J. Jordan Steel, K. Frankowski, Kelin Li, F. Schoenen, D. Frick   +9 more
semanticscholar   +1 more source