Results 151 to 160 of about 215,192 (350)

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Architecture of a Dodecameric Bacterial Replicative Helicase [PDF]

, 2012
Meike Stelter, Irina Gutsche, U. Kapp, Alexandre Bazin, Goran Bajic, Gaël Goret, Marc Jamin, Joanna Timmins, Laurent Terradot   +8 more
openalex   +1 more source

Long DNA constructs to study helicases and nucleic acid translocases using optical tweezers

, 2022
Clara Aicart-Ramos, Silvia Hormeño, Oliver J. Wilkinson, Mark S. Dillingham, Fernando Moreno‐Herrero   +4 more
openalex   +2 more sources

Behavioral and epileptic phenotypes in a CHD2‐related developmental delay model

Epilepsia, EarlyView.
Abstract Objective Heterozygous loss‐of‐function mutations in the CHD2 gene, encoding chromodomain helicase DNA‐binding protein 2, are associated with severe childhood onset epilepsy, global developmental delay, and autistic features. Animal models that accurately recapitulate human phenotypes are crucial for understanding rare neurodevelopmental ...
Anat Mavashov, Shaked Turk, Yael Sarusi, Marina Brusel, Rotem Ben Tov Perry, Shir Quinn, Yael Almog, Karni Vilian, Mor Yam, Igor Ulitsky, Moran Rubinstein   +10 more
wiley   +1 more source

Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes

Nucleic Acids Research, 2015
Bloom's syndrome helicase (BLM) is a member of the RecQ family of DNA helicases, which play key roles in the maintenance of genome integrity in all organism groups. We describe crystal structures of the BLM helicase domain in complex with DNA and with an
J. Newman, P. Savitsky, C. Allerston, Anna H. Bizard, Özgün Özer, Kata Sarlós, Y. Liu, E. Pardon, J. Steyaert, I. Hickson, O. Gileadi   +10 more
semanticscholar   +1 more source

RNA Translocation Coupled to Large-Scale Conformational Transitions of a Hexameric Helicase [PDF]

, 2015
Wen Ma, Klaus Schulten
openalex   +1 more source

Guidelines for Light‐Start One‐Pot RPA‐CRISPR‐Cas12a Assays for Foodborne Pathogen Detection

Food Safety and Health, EarlyView.
Light‐start one‐pot RPA‐CRISPR‐Cas12a detection schematic diagram. (A) Linear crRNA activation light‐start one‐pot workflow. (B) Caged crRNA activation light‐start one‐pot workflow. ABSTRACT Rapid and accurate detection of nucleic acids of foodborne pathogens is of vital importance for controlling the spread of foodborne diseases and safeguarding ...
Fan Li, Ruiting Yao, Xinxin Jiang, Haorui Zhu, Guoliang Li   +4 more
wiley   +1 more source

Modeling pathogenic mutations of human twinkle in Drosophila suggests an apoptosis role in response to mitochondrial defects.

PLoS ONE, 2012
The human gene C10orf2 encodes the mitochondrial replicative DNA helicase Twinkle, mutations of which are responsible for a significant fraction of cases of autosomal dominant progressive external ophthalmoplegia (adPEO), a human mitochondrial disease ...
Alvaro Sanchez-Martinez, Manuel Calleja, Susana Peralta, Yuichi Matsushima, Rosana Hernandez-Sierra, Alexander J Whitworth, Laurie S Kaguni, Rafael Garesse   +7 more
doaj   +1 more source

Human Enterovirus Nonstructural Protein 2CATPase Functions as Both an RNA Helicase and ATP-Independent RNA Chaperone

PLoS Pathogens, 2015
RNA helicases and chaperones are the two major classes of RNA remodeling proteins, which function to remodel RNA structures and/or RNA-protein interactions, and are required for all aspects of RNA metabolism.
Hongjie Xia, Peipei Wang, Guangchuan Wang, Jie Yang, Xianlin Sun, Wenzhe Wu, Y. Qiu, T. Shu, Xiaolu Zhao, Lei Yin, C. Qin, Yuanyang Hu, Xiaoping Zhou, B. Semler   +13 more
semanticscholar   +1 more source

Viral Helicases

, 2009
Helicases are motor proteins that use the free energy of NTP hydrolysis to catalyze the unwinding of duplex nucleic acids. Helicases participate in almost all processes involving nucleic acids. Their action is critical for replication, recombination, repair, transcription, translation, splicing, mRNA editing, chromatin remodeling, transport, and ...
Rajagopal, Vaishnavi, Patel, Smita S.
openaire   +1 more source